Results 101 to 110 of about 6,189,777 (260)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Modeling Stochastic Crop Yield Expectations with a Limiting Beta Distribution [PDF]
The use of plausible stochastic price processes in price risk analysis has allowed advances not seen in crop yield risk analysis. This study develops a stochastic process for yield modeling and risk management.
Hennessy, David A.
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Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Some evidence about the evolution of the size distribution of Italian firms by age [PDF]
In this short note we are interested in the distribution of Italian firm size by age. In the wake of other recent work, such as Cabral and Mata (2003) [On the evolution of firm size distribution: facts and theory.
Pasquale Cirillo
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Prediction distribution of generalized geometric series distribution and its different forms [PDF]
, 2009 The prediction distribution of generalized geometric series distribution (GGSD) and of its truncated and size-biased forms is derived and studied under the non-informative and beta prior distributions.
Hassan, Anwar, Khan, Shahjahan
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The complementary beta distribution
, 2002 The complementary beta distribution is proposed as a new distribution on the unit interval. It results from reversing the roles of the distribution and quantile functions of the beta distribution.
Jones, M. C., M.C. Jones
core +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
, 1905 Phi Beta Kappa was founded by five students at the College of William and Mary in 1776. This minute book documents the organization in the period 1905-1928.
Phi Beta Kappa +1 more
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