Results 131 to 140 of about 772,266 (306)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
ModellingBeta regression models are a class of models used frequently to model response variables in the interval (0, 1). Although there are articles in which these models are used to model clustered and longitudinal data, the prediction of random effects is ...
Olga Usuga-Manco +2 more
doaj +1 more source
Distributed Beta-assignment on Graphs. [PDF]
, 2017 Consider a set of items and a set of m colors, where each item is associated to one color. Consider also n computational agents connected by an arbitrary graph. Each agent initially holds a subset of the items. We analyze the problem of distributively assigning colors to agents in such a way that (a) each color is assigned to one agent only and (b) the
DE MARCO, GIANLUCA +3 more
openaire +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Product and Quotient of Independent Gauss Hypergeometric Variables
Ingeniería y Ciencia, 2011 In this article, we have derived the probability density functions of the productand the quotient of two independent random variables having Gauss hypergeometricdistribution.
Daya Krishna Nagar +1 more
doaj
Determinants of Blank and Null Votes in the Brazilian Presidential Elections
StatsThis study analyzes the factors influencing the proportions of blank and null votes in Brazilian municipalities during the 2018 presidential elections.
Renata Rojas Guerra +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Incremental Beta Distribution Weighted Fuzzy C-Ordered Means Clustering
InformationStreaming data is becoming more and more common in the field of big data and incremental frameworks can address its complexity. The BDFCOM algorithm achieves good results on common form datasets by introducing the ordering mechanism of beta distribution ...
Hengda Wang +3 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source