Results 141 to 150 of about 772,266 (306)

Global Inequality: Recent Evidence and Trends [PDF]

open access: yes
This paper examines the nature and extent of global and regional income distribution and inequality using the most recent country level data on income distribution drawn from World Bank and UNU-WIDER studies for the period 1993-2000. The methodology used
Chotikapanich, Duangkamon   +3 more
core  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Kummer Beta -Weibull Geometric Distribution A New Generalization of Beta -Weibull Geometric Distribution [PDF]

open access: yes, 2014
A new distribution is defined which is called kummer beta -Weibull geometric (KBWG) distribution. KBWG distribution is considered a new generalization for beta-Weibull geometric distribution. Various properties of KBWG distribution are obtained.
Abdel Wahed, Mohamed Lotfy   +1 more
core   +1 more source

The Modified Beta Weibull Distribution

open access: yesHacettepe Journal of Mathematics and Statistics, 2014
A new five-parameter model called the modified beta Weibull probability distribution is being introduced in this paper. This model turnsout to be quite flexible for analyzing positive data and has bathtub andupside down bathtub hazard rate function.Our main objectives are to obtain representations of certain statisticalfunctions and to estimate the ...
openaire   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Quantitative Methods for Evaluating Long-Term Career Attitudes of the Subjects of Modern Society («Model of the Life Trajectory»)

open access: yesУправленческое консультирование
The article is devoted to the problems of ideas of the subjects of modern society about the long-term prospects for the development of their life path (the so-called “life trajectories”).
P. V. Konyukhovsky, A. V. Yakovleva
doaj   +1 more source

Home - About - Disclaimer - Privacy