Results 51 to 60 of about 667,124 (235)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Natural succession and clearcutting as drivers of environmental heterogeneity and beta diversity in North American boreal forests [PDF]

, 2018
Clear-cutting alters natural ecosystem processes by reducing landscape heterogeneity. It is the dominant harvesting technique across the boreal zone, yet understanding of how environmental heterogeneity and beta diversity are structured in forest ...
Bourassa, Stephane, Garcia-Tejero, Sergio, O'Halloran, John, Oxbrough, Anne, Spence, John R   +4 more
core   +4 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Unraveling spatiotemporal variability of arbuscular mycorrhizal fungi in a temperate grassland plot [PDF]

, 2019
© The Author(s), 2019. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Goldmann, K., Boeddinghaus, R. S., Klemmer, S., Regan, K. M., Heintz-Buschart, A., Fischer, M., Prati,
Berner, Doreen, Boeddinghaus, Runa S., Buscot, François, Fischer, Markus, Goldmann, Kezia, Heintz‐Buschart, Anna, Kandeler, Ellen, Klemmer, Sandra, Marhan, Sven, Piepho, Hans‐Peter, Prati, Daniel, Regan, Kathleen M., Wubet, Tesfaye   +12 more
core   +2 more sources

Fast Computations for Measures of Phylogenetic Beta Diversity

PLOS ONE, 2016
For many applications in ecology, it is important to examine the phylogenetic relations between two communities of species. More formally, let [Formula: see text] be a phylogenetic tree and let A and B be two samples of its tips, representing the examined communities.
Tsirogiannis, Constantinos, Sandel, Brody   +1 more
openaire   +5 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Broad Line Region Physical Conditions along the Quasar Eigenvector 1 Sequence

, 2010
[Abridged] We compare broad emission line profiles and estimate line ratios for all major emission lines between Ly-alpha and H-beta in a sample of six quasars.
Bachev, Baldwin, Barthel, Bentz, Bon, Bonnell, Boroson, Brotherton, C. A. Negrete, Carswell, Collin, Collin-Souffrin, Collin-Souffrin, Collin-Souffrin, Corbin, Corbin, Corbin, D. Dultzin, Davidson, Denney, Eracleous, Eracleous, Espey, Ferland, Ferland, Ferland, Gaskell, Gaskell, Gaskell, Gaskell, Gezari, Gordon, Halpern, Halpern, Hamann, J. W. Sulentic, Johansson, Juarez, Korista, Korista, Kriss, Krongold, La Mura, Laor, Laor, Lauer, Marconi, Marziani, Marziani, Marziani, Marziani, Marziani, Marziani, Marziani, Marziani, Marziani, Mathews, Mathews, Mathur, Matsuoka, Matsuoka, Morris, Negrete, Netzer, Netzer, P. Marziani, Peterson, Peterson, Punsly, R. Bachev, Rafanelli, Richards, S. Zamfir, Sanders, Sani, Sargent, Schlegel, Shang, Shapovalova, Shemmer, Shields, Small, Snedden, Strateva, Sulentic, Sulentic, Sulentic, Sulentic, Sulentic, Sulentic, Sulentic, Sulentic, Sulentic, Sulentic, Turler, Tytler, Vanden Berk, Vestergaard, Vestergaard, Wang, Wang, Wilkes, Wills, Young, Zamfir, Zamfir, Zhang, Zheng   +107 more
core   +1 more source