Results 51 to 60 of about 275,974 (250)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Native diversity contributes to composition heterogeneity of exotic floras

Ecosphere, 2023
Variation in species composition among sites (beta diversity) is generally thought to be driven by environmental filtering and dispersal limitation, but the role of biotic interactions has not been sufficiently addressed.
Pengdong Chen, Changchao Shen, Jie Ren, Wenchao Qin, Jiahui Yi, Shuping Guan, Zhibin Tao, Wei Huang, Evan Siemann   +8 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Natural succession and clearcutting as drivers of environmental heterogeneity and beta diversity in North American boreal forests. [PDF]

PLoS ONE, 2018
Clear-cutting alters natural ecosystem processes by reducing landscape heterogeneity. It is the dominant harvesting technique across the boreal zone, yet understanding of how environmental heterogeneity and beta diversity are structured in forest ...
Sergio García-Tejero, John R Spence, John O'Halloran, Stephane Bourassa, Anne Oxbrough   +4 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Taxonomic and Functional Beta Diversity Patterns and Their Driving Factors of the Fish Assemblages Around Marine Islands

Journal of Marine Science and Engineering
Beta diversity is an important way to analyze community assembly mechanisms in different habitats or along environmental gradients. However, research on marine fish assemblages around islands has lagged, especially for functional beta diversity.
Guangjie Fang, Jun Liang, Rijin Jiang, Yazhou Zhang, Junlin Chen, Chuanxi Chen, Mingda Yang, Yongdong Zhou   +7 more
doaj   +1 more source

Potent in vitro and in vivo antifungal activity of a small molecule host defense peptide mimic through a membrane-active mechanism

Scientific Reports, 2017
Lethal systemic fungal infections of Candida species are increasingly common, especially in immune compromised patients. By in vitro screening of small molecule mimics of naturally occurring host defense peptides (HDP), we have identified several active ...
Lorenzo P. Menzel, Hossain Mobaswar Chowdhury, Jorge Adrian Masso-Silva, William Ruddick, Klaudia Falkovsky, Rafael Vorona, Andrew Malsbary, Kartikeya Cherabuddi, Lisa K. Ryan, Kristina M. DiFranco, David C. Brice, Michael J. Costanzo, Damian Weaver, Katie B. Freeman, Richard W. Scott, Gill Diamond   +15 more
doaj   +1 more source

Archipelago reserves, a new option to protect montane entomofauna and beta-diverse ecosystems

Revista Mexicana de Biodiversidad, 2018
Beta diversity is often a dominant characteristic in mountain systems and naturally fragmented ecosystems. However, natural protected areas are traditionally designed to protect ecosystems with high alpha and low beta diversity.
Victor Moctezuma, Gonzalo Halffter, Alfonsina Arriaga-Jiménez   +2 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Genotypic-Phenotypic Diversity in Beta Thalassemia

Mediterranean Journal of Hematology and Infectious Diseases, 2014
The remarkable variability in clinical severity of the thalassemia reflects both genetic and environmental factors. It is becoming apparent that the genetic element involves many loci, some of which are directly involved with the basic defect in globin ...
Ravindra Kumar, Vandana Arya
doaj