Results 101 to 110 of about 13,948,536 (305)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Coupon Collector Problem with Reset Button

Mathematics
We consider the following generalization of the classical coupon collector problem. We assume that, in addition to the initial collection of standard coupons, there is one more coupon that acts as a reset button, removing all coupons from the part of the
Jelena Jocković, Bojana Todić
doaj   +1 more source

Monkeypox detection from skin lesion images using an amalgamation of CNN models aided with Beta function-based normalization scheme. [PDF]

PLoS One, 2023
Pramanik R, Banerjee B, Efimenko G, Kaplun D, Sarkar R.   +4 more
europepmc   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

On the Application of a Hypergeometric Identity to Generate Generalized Hypergeometric Reduction Formulas

Axioms
We systematically exploit a new generalized hypergeometric identity to obtain new hypergeometric summation formulas. As a consistency test, alternative proofs for some special cases are also provided.
Juan Luis González-Santander
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A new extended Mulholland's inequality involving one partial sum

Open Mathematics
By using the weight coefficients and the techniques of real analysis, a new extended Mulholland’s inequality with multi-parameters involving one partial sum is given. The equivalent statements of the best value related to several parameters are provided.
Peng Ling, Yang Bicheng
doaj   +1 more source

Exploring new types of Hardy-Hilbert integral inequalities

E-Journal of Analysis and Applied Mathematics
This article explores two new types of Hardy-Hilbert integral inequalities constructed using flexible kernel functions. These functions are versatile due to the interplay of two or more parameters, as well as their asymmetric structural properties.
Christophe Chesneau
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source