Results 111 to 120 of about 1,232,344 (309)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The effects of the adipocyte-secreted proteins resistin and visfatin on the pancreatic beta-cell [PDF]

, 2009
A thesis submitted in partial fulfilment of the requirements of the University of Wolverhampton for degree of Doctor of PhilosophyAdipose tissue secreted proteins (adipokines) have been proposed to form a link between obesity and type 2 diabetes (T2D ...
Onyango, David J.
core  

Regional and global changes in TCR [alpha][beta] T cell repertoires in the gut are dependent upon the complexity of the enteric microflora

, 2010
The repertoire of gut associated T cells is shaped by exposure to microbes, including the natural enteric microflora. Previous studies compared the repertoire of gut associated T cell populations in germ free (GF) and conventional mammals often focussing
Beal, R.K., Smith, A.L., Tom Humphrey, Friedman, A., Friedman, A, Beal, RK, Bailey, M, Adrian L. Smith, Humphrey, T., Claire Powers, Wu, X, Bailey, M., William N. Mwangi, Mwangi, WN, Smith, Adrian, Watson, M, Xikun Wu, Mwangi, W.N., Richard K. Beal, Michael Watson, Humphrey, TJ, Wu, X., Humphrey, T, Watson, Mick, Smith, AL, Aharon Friedman, Powers, C, Powers, C., Michael Bailey   +28 more
core   +1 more source

Influence of Area Distribution Along the Span Direction on Flapping Wing Aerodynamics in Hover Based on Numerical Modeling Analysis

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
This study performed a numerical investigation to explore the effect of span-wise area distribution on flapping wing aerodynamics in hovering configuration using an in-house developed flow solver.
Guilin Wu, Shuanghou Deng, Qingxi Li
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Four Families of Summation Formulas for ₄F₃(1) with Application

Axioms
A collection of functions organized according to their indexing based on non-negative integers is grouped by the common factor of fixed integer N. This grouping results in a summation of N series, each consisting of functions partitioned according to ...
Belakavadi Radhakrishna Srivatsa Kumar, Arjun K. Rathie, Junesang Choi   +2 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Investigation of molecular and cellular events associated with beta cell function and elucidation of extracellular RNAs as potential biomarker for diabetes [PDF]

, 2009
Diabetes is a chronic disorder of glucose metabolism and a major cause of premature mortality. The potential use of replacement beta cells as therapy for diabetes requires an ability to culture such cells while maintaining their functional status ...
Rani, Sweta
core