Results 101 to 110 of about 7,337,590 (301)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Exploring new types of Hardy-Hilbert integral inequalities

E-Journal of Analysis and Applied Mathematics
This article explores two new types of Hardy-Hilbert integral inequalities constructed using flexible kernel functions. These functions are versatile due to the interplay of two or more parameters, as well as their asymmetric structural properties.
Christophe Chesneau
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Effect of protein glycation by methylglyoxal on pancreatic beta cell function [PDF]

Methylglyoxal is a physiological dicarbonyl metabolite and potent argininedirected glycating agent. It often modifies proteins at functional sites producing loss of positive charge, structural distortion and inactivation.
Tym, Amy
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

La danza, a cura di Simone Beta. Traduzione di Marina Nordera, con testo a fronte

, 1992
Il volume consiste nella traduzione italiana (per opera di Marina Nordera) del trattato La danza (De saltatione) di Luciano. L'introduzione (pp. 9-47), le note al testo (pp. 111-138) e la bibliografia (pp. 139-142) sono di Simone Beta.
BETA, SIMONE, Nordera M.
core   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Influence of Area Distribution Along the Span Direction on Flapping Wing Aerodynamics in Hover Based on Numerical Modeling Analysis

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
This study performed a numerical investigation to explore the effect of span-wise area distribution on flapping wing aerodynamics in hovering configuration using an in-house developed flow solver.
Guilin Wu, Shuanghou Deng, Qingxi Li
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

I rivali di Aristofane

, 2002
Partendo dalla recente pubblicazione di un volume curato da D. Harvey e J. Wilkins (The rivals of Aristophanes. Studies in Athenian Old Comedy, London 2000), Simone Beta discute sull'importanza dello studio dei frammenti comici per una conoscenza ...
BETA, SIMONE, Simone Beta
core   +1 more source