Results 131 to 140 of about 1,172,738 (263)

Patient-derived induced pluripotent stem cells for precision modelling of monogenic beta cell disorders. [PDF]

Front Endocrinol (Lausanne)
Deng L, Krishnamurthy M.
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Beta Blocker Toxicity at Therapeutic Doses: A Look Into Carvedilol Use in the Elderly. [PDF]

Clin Case Rep
Amo-Tachie S.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

beta‐Adrenoceptor antagonists and respiratory function. [PDF]

British Journal of Clinical Pharmacology, 1978
openaire   +4 more sources

The Gaugino \beta-Function

, 1997
We present an elegant exact formula for the gaugino $\beta$-function in a softly-broken supersymmetric gauge theory, of the form $\beta_M = {\cal O}(\beta_g/g)$, where $\beta_g$ is the gauge $\beta$ function and ${\cal O}$ is a simple differential operator acting on the gauge coupling $g$ and the Yukawa coupling.
Jack, I., Jones, D. R. T.
openaire   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Cardioprotective role of antihypertensive treatment in chemotherapy-induced cardiotoxicity: umbrella review of meta-analyses of randomised controlled trials. [PDF]

Open Heart
Rostami A, Ashraf H, Hosseininasab A.
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Thyroid function tests and resting heart rate in Graves' disease: a prospective longitudinal study. [PDF]

Endocr Connect
Egger B, Riedmann U, Schmitt L, Kraus DA, Pichler H, Trummer C, Theiler-Schwetz V, Lindschinger S, März W, Tsybrovskyy O, Reichhartinger M, Pilz S.   +11 more
europepmc   +1 more source