Results 161 to 170 of about 1,095,525 (267)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

XBP1 expression in pancreatic islet cells is associated with poor glycaemic control especially in young non-obese onset diabetes across ancestries. [PDF]

Commun Med (Lond)
Siddiqui MK, Dupuis T, Anjana RM, Dawed AY, Bigossi M, Srinivasan S, Hodgson S, Adedire ET, Taylor A, Saravanan J, Sartori A, Davtian D, Venkatesan R, McNeilly A, Cantley J, Mathur R, Sattar N, Genes & Health Research Team, Finer S, Pearson ER, Pradeepa R, Mohan V, Palmer CNA, Brown AA, Viñuela A.   +24 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The role of the beta cell in type 2 diabetes: new findings from the last 5 years. [PDF]

Diabetologia
Yau B, Ghislain J, Kebede MA, Hughes J, Poitout V.   +4 more
europepmc   +1 more source

HIGH DOSE SUPPLEMENTATION WITH BETA-CAROTENE: ITS EFFECT ON SERUM LEVEL OF VITAMIN A & LIVER FUNCTION IN RABBITS [PDF]

, 1984
Enrique M. Ostrea, David J. Kroll
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Beta-Cell Secretory Function in Recent-Onset Type 2 Diabetes Mellitus: A Comparative Study Across Body Mass Index Categories. [PDF]

Cureus
S M S, Valliyot B, V K P.
europepmc   +1 more source

191 Early weaning in pigs induces long-term alterations in intestinal nutrient transporter function and expression partially via beta adrenergic enteric neural receptors

, 2019
Yihang Li, Karina Matos, Mrigendra Rajput, Adam J. Moeser   +3 more
openalex   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Ethnic differences in beta cell function and pancreatic fat in Black African and White European men across a spectrum of glucose tolerance. [PDF]

Diabetologia
Whelehan G, Hakim O, Ladwa M, Bello O, Bodicoat DH, Umpleby AM, Amiel SA, Goff LM.   +7 more
europepmc   +1 more source