Results 211 to 220 of about 1,095,525 (267)

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Autoimmune pathogenesis of gestational diabetes mellitus: the risk of progression to type 1 diabetes mellitus. [PDF]

Front Endocrinol (Lausanne)
Skibińska M, Kacerovsky M, Grzesiak M, Wujcicka WI.   +3 more
europepmc   +1 more source

Corrections to “Defending CNN Against FGSM Attacks Using Beta-Based Personalized Activation Functions and Adversarial Training”

Hanen Issaoui, Asma ElAdel, Ahmed Zouinkhi, Mourad Zaied, Lazhar Khriji, Sarvar Hussain Nengroo, Sangkeum Lee   +6 more
openalex   +1 more source

Adjunct Thymosin Beta-4 Treatment Influences Effector Cell Function During Pseudomonas aeruginosa-Induced Keratitis

, 2020
Yuxin Wang, Thomas W. Carion, Ebrahim Abdul Shukkur, Gabriel Sosne, Elizabeth A. Berger   +4 more
openalex   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

The association of common infectious exposures with cognitive performance in community-dwelling older adults. [PDF]

Alzheimers Dement
Roberts JA, Elkind MSV, Liu M, Assuras S, Levin BE, Guzman V, Rundek T, Gutierrez J.   +7 more
europepmc   +1 more source

The expression and function of the human cytomegalovirus encoded beta-chemokine receptor homolog, US28 /

, 1998
Julie Randolph‐Habecker
openalex   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Improving Maximum Tolerated Dose Selection in Model-Assisted Designs for Phase I Trials Through Bayesian Dose-Response Model. [PDF]

Pharm Stat
Wakayama R, Momozaki T, Ando S.
europepmc   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source