Results 221 to 230 of about 13,948,536 (305)

Linking movement-related beta oscillations to cortical excitability, structural damage, and fatigue in multiple sclerosis. [PDF]

Brain Commun
Tatti E, Benelli A, Cinti A, Cortese R, Serbina A, Kulapurathazhe AJ, Saed S, Luchetti L, Cudeiro J, Zhang J, de Mauro A, Neri F, Stromillo ML, Baldi TL, d'Aurizio N, Battaglini M, Plantone D, Righi D, Massucco E, Giannotta A, Lomi F, Scoccia A, Lai G, Ulivelli M, Ghilardi MF, De Stefano N, Rossi S.   +26 more
europepmc   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

C-peptide in Precision Diabetes Care and Beyond: A Comprehensive Review. [PDF]

Clin Med Insights Endocrinol Diabetes
Vinay ES, Laxmi Narsimha Rao B, Saf N, Gautam D.   +3 more
europepmc   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Functional shape of the proximal radioulnar joint: anatomical characterization through Alpha and Beta Angles. [PDF]

JSES Rev Rep Tech
Traverso A, Vismara V, Cassin S, Rojero-Gil EK, Lante E, Sainiuc MA, Zagarella A, Randelli PS, Arrigoni P.   +8 more
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Utilizing fractional-order operator to Alzheimer's disease dynamics. [PDF]

Sci Rep
Nisar KS, Farman M.
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Heart Failure in Kidney Transplant Recipients: Narrative Review of Risk Factors, Therapy, and Current Gaps in Management. [PDF]

Cardiol Ther
Ghimire A, Al-Zaneen G, Michaud JB, Worthen G, Rampersad C, Singh SKS, Lam NN, Kim SJ, Tennankore KK, Vinson A.   +9 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source