Results 71 to 80 of about 1,232,344 (309)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A new extended Mulholland's inequality involving one partial sum

Open Mathematics
By using the weight coefficients and the techniques of real analysis, a new extended Mulholland’s inequality with multi-parameters involving one partial sum is given. The equivalent statements of the best value related to several parameters are provided.
Peng Ling, Yang Bicheng
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

On the integral equation of the boundary value problem for the essentially loaded differential heat operator

Қарағанды университетінің хабаршысы. Математика сериясы, 2016
In the article the Volterra integral equations of the second kind with the given kernel are investigated. This kind of integral equations arises in the solving of some boundary value problems for essential loaded differential heat operator in an ...
A.N. Yesbayev, G.A. Yessenbayeva
doaj  

2型糖尿病患者的β细胞功能:能被保留或增强吗?

Journal of Diabetes, 2023
Type 2 diabetes (T2DM) is a complex metabolic disorder manifested by hyperglycemia, insulin resistance, and deteriorating beta‐cell function. A way to prevent progression of the disease might be to enhance beta‐cell function and insulin secretion ...
Laure Sayyed Kassem, Aman Rajpal, Margarita Victoria Barreiro, Faramarz Ismail‐Beigi   +3 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Knockout of the Bcmo1 gene results in an inflammatory response in female lung, which is suppressed by dietary beta-carotene [PDF]

, 2010
Beta-carotene 15,15'-monooxygenase 1 knockout (Bcmo1 (-/-)) mice accumulate beta-carotene (BC) similarly to humans, whereas wild-type (Bcmo1 (+/+)) mice efficiently cleave BC.
Yvonne G. J. van Helden, Georg Lietz, Roger W. L. Godschalk, Jaap Keijer, Teerds, K., Hessel, S., Keijer, J., Schooten, F.J., van, Adrian Wyss, von Lintig, J., Sandra G. Heil, Heil, S.G., Kramer, E., Lietz, G., van Schooten, F.J., Lintig, J., von, Amengual, J., Wyss, A., Ribot, J., Katja Teerds, Frederik J. van Schooten, Helden, Y.G.J., Johannes von Lintig, Godschalk, R.W.L., M. Luisa Bonet, van Helden, Y.G., Evelien Kramer, Joan Ribot, Susanne Hessel, Teerds, K.J., Bonet, M.L., Jaume Amengual   +31 more
core   +1 more source

Investigation on the response of Fagus orientalis Lipsky to some environmental variables using beta function and its comparison with Gaussian function (Case study: Kheyrud forest research station( [PDF]

مجله جنگل ایران, 2013
The current study was done in Patom, Namkhaneh, Gorazbon, Chelir and Baharbon districts in Kheyrud forest. A stratified sampling method based on landform was used to locate 190 0.1 ha circular sample plots in beech dominated forests.
doaj  

Certain Properties Associated with Generalized $M$-Series using Hadamard Product [PDF]

Sahand Communications in Mathematical Analysis
The generalized $M$-series is a hybrid function of generalized Mittag-Leffler function and generalized hypergeometric function.  The principal aim of this paper is to investigate certain properties resembling those of the Mittag-Leffler and ...
Dheerandra Sachan, Dinesh Kumar, Kottakkaran Nisar   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source