Results 51 to 60 of about 100 (99)

Nanoscale Analysis beyond Imaging by Atomic Force Microscopy: Molecular Perspectives on Oncology and Neurodegeneration

Small Science, Volume 5, Issue 11, November 2025.
Cancer and neurodegeneration share interconnected nanosized molecular pathways. Novel nanobiomedicine approaches promise targeted biomarkers and therapies. Atomic force microscopy (AFM) is invaluable to characterize nanosized biomolecular processes beyond imaging.
Carlos Marcuello, KeeSiang Lim, Giacomo Nisini, Vadim S. Pokrovsky, João Conde, Francesco Simone Ruggeri   +5 more
wiley   +1 more source

Functional Analysis and Transcriptional Regulation of Oocyte-Specific Nuclear Transporter KPNA7

, 2015
The finely orchestrated development and maturation of the oocytes has been the focus of many studies in which oocyte-specific genes essential for folliculogenesis and early embryonic development have been identified. Studies using knockout mice models of
Wang, Lei
core   +1 more source

SenExo‐cCCT2 Reprograms Senescence Response and Anti‐Tumor Immunity Following FOLFIRINOX Chemotherapy in Pancreatic Ductal Adenocarcinoma

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This study demonstrates that SenExo‐cCCT2 enables targeted delivery of cCCT2 to pancreatic cancer cells, where it disrupts IPO13‐mediated nuclear translocation of UBC9, impairing SUMOylation‐dependent DNA damage repair and inducing senescence. Senescent tumor cells secrete CXCL10 to recruit CD8⁺ T‐cells while upregulating PD‐L1.
Shuncang Zhu, Yinhao Chen, Hongyi Lin, Jinpeng Lu, Yu Pan, Ge Li, Yongding Wu, Haoxiang Zhang, Xiaoxiao Huang, Yiting Chen, Huangjing Chen, Long Jin, Min Huang, Chengyu Liao, Long Huang, Yifeng Tian, Zuwei Wang, Qiaowei Li, Shi Chen   +18 more
wiley   +1 more source

PARP16/ARTD15 Is a Novel Endoplasmic-Reticulum-Associated Mono-ADP-Ribosyltransferase That Interacts with, and Modifies Karyopherin-ß1

PLoS ONE, 2012
Protein mono-ADP-ribosylation is a reversible post-translational modification that modulates the function of target proteins. The enzymes that catalyze this reaction in mammalian cells are either bacterial pathogenic toxins or endogenous cellular ADP-ribosyltransferases.
Di Paola Simone, Micaroni Massimo, Di Tullio Giuseppe, Buccione Roberto, Di Girolamo Maria   +4 more
openaire   +8 more sources

Computational Analysis of Exosome‐Derived Signature in TNBC: Integrating Single‐Cell and Bulk Transcriptomics for Prognosis Prediction

Clinical and Translational Science, Volume 18, Issue 10, October 2025.
ABSTRACT Triple‐negative breast cancer (TNBC) is a particularly aggressive subtype of breast cancer with limited targeted therapeutic options. Exosomes, small membrane vesicles secreted by cells, play a crucial role in intercellular communication and material exchange. However, the role of exosome‐related genes (ERGs) in TNBC remains unclear.
Yuan Zhang, Ming Zhao, Lei Hou, Long Jin, Jun Bai, Yunzhi Dang   +5 more
wiley   +1 more source

Disruption of ARID1B Recruitment to the Nuclear Pore Complex as a New Anticancer Therapeutic Strategy

Advanced Science, Volume 12, Issue 36, September 25, 2025.
This study identifies ARID1B as a chromatin‐bound driver of tumor growth in TNBC. ARID1B impairs ARID1A function and directly activates oncogenic programs through SWI/SNF remodeling. Its nuclear localization, mediated by the KPNA2–KPNB1–RANBP2 import machinery, is essential for its tumor‐promoting activity.
Olena Odnokoz, Anupam Banerjee, Xin Cui, Lidan Zeng, Amad Uddin, Christopher Li, Yueming Zhu, Mengyuan Zhang, Xiaodong Lu, Nagendra S. Yarla, Lu Wang, Jindan Yu, Jonathan C. Zhao, Ivet Bahar, Yong Wan   +14 more
wiley   +1 more source

Evolutionary and transcriptional analysis of karyopherin beta superfamily proteins

, 2008
In eukaryotes, karyopherin beta superfamily proteins mediate nucleocytoplasmic transport of macromolecules. We investigated the evolutionary and transcriptional patterns of these proteins using bioinformatics approaches. No obvious homologs were found in
Ji, Z. L., Tao, T., 陶涛, Tartakoff, A. M., Quan, Y., Wang, X.   +5 more
core  

The Long Noncoding RNA ΒFaar Promotes White Adipose Tissue Browning and Prevents Diet‐Induced Obesity

Advanced Science, Volume 12, Issue 35, September 18, 2025.
βFaar selectively targets and inhibits the GTPase activity of the RAB18 protein, thereby reducing LD volume. Conversely, βFaar promotes nuclear translocation of the transcription factor IRF4 in inguinal white adipose tissue (iWAT), facilitating the browning of white adipose tissue and attenuating body fat accumulation.
Yue Yang, Bin Huang, Baixue Sha, Danni Gao, Yimeng Qin, Ziyi Li, Xi Chen, Yinuo Jin, Yi Pan, Yanfeng Zhang, Yumeng Shen, Yu Liu, Liang Jin, Fangfang Zhang   +13 more
wiley   +1 more source

Nanocarrier‐Based Systems for Targeted Delivery: Current Challenges and Future Directions

MedComm, Volume 6, Issue 9, September 2025.
Recent advances in nanocarrier‐mediated delivery for nuclear targeting Cell nucleus: key target for improved therapeutic outcomes including chemotherapy, photodynamic therapy, and gene therapy Nuclear‐targeted drug delivery strategy: including nuclear localization sequence (NLS)‐mediated active targeting and passive strategies • Challenges in nuclear ...
Zichen Xu, Yongyi Xie, Wenjie Chen, Wei Deng   +3 more
wiley   +1 more source

A cellular model of TDP‐43 induces phosphorylated TDP‐43 aggregation with distinct changes in solubility and autophagy dysregulation

The FEBS Journal, Volume 292, Issue 18, Page 4870-4897, September 2025.
TDP‐43 protein plays a pathological role in sporadic and familial amyotrophic lateral sclerosis (ALS). Here, we developed a cellular model overexpressing TDP‐43 with three mutations linked to familial ALS, termed ‘3X‐TDP‐43’. Mutant 3X‐TDP‐43 expression showed deficits in autophagy flux and colocalization with stress granules.
Matthew B. Dopler, Muhammad I. Abeer, Sanaz Arezoumandan, Keyshawn Cox, Tyler L. Petersen, Esther H. Daniel, Carlton L. Cannon III, Angelica Bautista, Kennedy D. Blancher, Alysia M. Bland, Kylie J. Bond, Dominque A. Davis, Jessica M. Francois, Eliana J. McCray, Justin M. Morgan, Jessica L. Pulliam, Zymir A. Robinson, Mykia J. Taylor, James A. Dowell, Nigel J. Cairns, Michael A. Gitcho   +20 more
wiley   +1 more source