Results 61 to 70 of about 100 (99)

Characterization of Nuclear Localization Signals of Karyopherin-Mediated Nuclear Import

, 2012
Nucleocytoplasmic transport is mediated by Karyopherin beta (Kap beta) proteins in a Ran-dependent manner. Ten import Kap betas recognize their cargos through the nuclear localization signals (NLSs) and carry them into the nucleus.
Zhang, Zi Chao
core  

The role of Karyopherin β1 in the nuclear import of HIV-1 proteins

, 2014
Includes abstract.
Shaw, Tamlyn Marion
core  

Xenopus Ran-binding protein 1: molecular interactions and effects on nuclear assembly in Xenopus egg extracts

, 1997
Ran is a nuclear GTPase implicated in nucleocytoplasmic transport, the maintenance of nuclear structure, mRNA processing, and cell cycle regulation, By two-hybrid interaction in yeast, we have identified a Xenopus homologue of Ran-binding protein 1 ...
Zhang, CM, Goldberg, MW, Clarke, PR, Hughes, Mike, Nicolas, Francisco J., Watton, Sandra J., Nicolas, FJ, Hughes, M, Clarke, Paul R., Watton, SJ, Zhang, Chuanmao, Goldberg, Martin W.   +11 more
core  

Structural and Biochmical Studies of Nuclear Import Factor Karyopherin Beta-2

, 2007
Karyopherinbeta (Kapbeta ) proteins recognize nuclear localization and export signals (NLS/NES) and mediate the transport of macromolecules across the nuclear envelope, a process regulated by Ran GTPase through its nucleotide cycle.
Cansizoglu, Ahmet Ertugrul
core  

A Novel Karyopherin-β Homolog Is Developmentally and Hormonally Regulated in Fetal Lung

American Journal of Respiratory Cell and Molecular Biology, 2000
Abstract To investigate molecular mechanisms of lung organogenesis, we used representational difference analysis to search for glucocorticoid-inducible genes in developing lung in a fetal rat model. Messenger RNA prepared from fetal and adult rat lung was used to prepare “representative amplicons.” Adult-lung complementary DNA (cDNA ...
C, Zhang, N B, Sweezey, S, Gagnon, B, Muskat, D, Koehler, M, Post, F, Kaplan   +6 more
openaire   +2 more sources

Nuclear import of hnRNP A1 is mediated by a novel cellular cofactor related to karyopherin-β

Journal of Cell Science, 1997
ABSTRACT Heterogeneous nuclear ribonucleoprotein A1 contains a sequence, termed M9, that functions as a potent nuclear localization signal (NLS) yet bears no similarity to the welldefined basic class of NLSs. Here, we report the identification of a novel human protein, termed MIP, that binds M9 specifically both in vivo and in vitro yet ...
R A, Fridell, R, Truant, L, Thorne, R E, Benson, B R, Cullen   +4 more
openaire   +2 more sources

Identification of karyopherin β as an immunogenic antigen of the malaria parasite using immune mice and human sera

Parasite Immunology, 2005
SUMMARY A differential immunoscreening of the λgt11 Plasmodium falciparum genomic expression library was carried out using anti‐P. yoelii sera (convalescent‐phase mouse sera) and immune sera collected from healthy adults, to identify novel cross‐reactive and possibly protective antigens of the parasite.
Asif, Mohmmed, Shivendra, Kishore, Kailash P, Patra, Palakodeti V N, Dasaradhi, Pawan, Malhotra, Virander S, Chauhan   +5 more
openaire   +2 more sources

Characterization of p92, Karyopherin  , Co-Purified with N-Acetylglucosamine-Bearing Nucleoporins from Rat Liver Nuclear Envelopes

Journal of Biochemistry, 1996
A 92k protein (p92) was purified from the wheat germ agglutinin-Sepharose (WGA-Sepharose) bound fraction of a rat liver nuclear envelope salt-extract by DEAE-5PW and hydroxyapatite HPLCs. Partial amino acid sequence analysis of p92 revealed that it is karyopherin beta, which was found recently in the cytosolic fraction.
S, Makifuchi, M, Takeuchi, S, Kawahire, S, Odani, T, Ichimura, S, Omata, T, Horigome   +6 more
openaire   +2 more sources

Importin-β/karyopherin-β1 modulates mitotic microtubule function and taxane sensitivity in cancer cells via its nucleoporin-binding region

Oncogene, 2019
The nuclear transport receptor importin-β/karyopherin-β1 is overexpressed in cancers that display genomic instability. It is regarded as a promising cancer target and inhibitors are being developed. In addition to its role in nucleo-cytoplasmic transport, importin-β regulates mitosis, but the programmes and pathways in which it operates are defined ...
Verrico, Annalisa, Rovella, Paola, Di Francesco, Laura, Damizia, Michela, Staid, David Sasah, Le Pera, Loredana, Schininà, M Eugenia, Lavia, Patrizia   +7 more
openaire   +2 more sources

Distinct nuclear import and export pathways mediated by members of the karyopherin beta family.

Journal of cellular biochemistry, 1998
Transport of proteins into and out of the nucleus occurs through nuclear pore complexes (NPCs) and is mediated by the interaction of transport factors with nucleoporins at the NPC. Nuclear import of proteins containing classical nuclear localization signals (NLSs) is mediated by a heterodimeric protein complex, composed of karyopherin alpha and beta1 ...
openaire   +1 more source