Results 51 to 60 of about 15,641,513 (303)

Age-corrected beta cell mass following onset of type 1 diabetes mellitus correlates with plasma C-peptide in humans. [PDF]

PLoS ONE, 2011
BackgroundThe inability to produce insulin endogenously precipitates the clinical symptoms of type 1 diabetes mellitus. However, the dynamic trajectory of beta cell destruction following onset remains unclear. Using model-based inference, the severity of
David J Klinke
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

A Characterization of the Domain of Beta-Divergence and Its Connection to Bregman Variational Model

Entropy, 2017
In image and signal processing, the beta-divergence is well known as a similarity measure between two positive objects. However, it is unclear whether or not the distance-like structure of beta-divergence is preserved, if we extend the domain of the beta-
Hyenkyun Woo
doaj   +1 more source

The Impact of Portal Satisfaction on Portal Use and Health-Seeking Behavior: Structural Equation Analysis

Journal of Medical Internet Research, 2020
BackgroundOur study addresses a gap in the modern information systems (IS) use literature by investigating factors that explain patient portal satisfaction (SWP) and perceptions about health-seeking behavior (HSB).
Silver, Reginald A, Subramaniam, Chandrasekar, Stylianou, Antonis   +2 more
doaj   +1 more source

A synthetic model of human beta-thalassemia erythropoiesis using CD34+ cells from healthy adult donors. [PDF]

PLoS ONE, 2013
Based upon the lack of clinical samples available for research in many laboratories worldwide, a significant gap exists between basic and clinical studies of beta-thalassemia major.
Y Terry Lee, Ki Soon Kim, Colleen Byrnes, Jaira F de Vasconcellos, Seung-Jae Noh, Antoinette Rabel, Emily R Meier, Jeffery L Miller   +7 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Re-expression of IGF-II is important for beta cell regeneration in adult mice [PDF]

, 2012
Background The key factors which support re-expansion of beta cell numbers after injury are largely unknown. Insulin-like growth factor II (IGF-II) plays a critical role in supporting cell division and differentiation during ontogeny but its role in the
Nattkemper, Tim Wilhelm ; https://orcid.org/, Zhou Luxian, Abouna, Sylvie, Julia Herold (136338), James Young (44149), Nattkemper Tim Wilhelm, Abouna Sylvie, Nakhai Hassan, Epstein David, Tim Wilhelm Nattkemper, Herold Julia, Pelengaris Stella, Young, James, Khan, Michael, Stella Pelengaris, Herold, Julia, Nakhai, Hassan, Stella Pelengaris (71018), Hassan Nakhai (136340), Pelengaris, Stella, Sylvie Abouna (71019), Zhou, Luxian, Young James, Luxian Zhou, Michael Khan, Michael Khan (71023), Epstein, David, David Epstein, Luxian Zhou (136331), Hassan Nakhai, Khan Michael, Sylvie Abouna, Epstein, D. B. A., James Young, Nattkemper, Tim W., David Epstein (136335), Tim Wilhelm Nattkemper (136339), Julia Herold   +37 more
core   +2 more sources

Maximum lilkelihood estimation in the $\beta$-model

The Annals of Statistics, 2013
We study maximum likelihood estimation for the statistical model for undirected random graphs, known as the $\beta$-model, in which the degree sequences are minimal sufficient statistics. We derive necessary and sufficient conditions, based on the polytope of degree sequences, for the existence of the maximum likelihood estimator (MLE) of the model ...
Rinaldo, Alessandro, Petrović, Sonja, Fienberg, Stephen E.   +2 more
openaire   +4 more sources

Applications of beta-mixture models in bioinformatics [PDF]

Bioinformatics, 2005
We propose a beta-mixture model approach to solve a variety of problems related to correlations of gene-expression levels. For example, in meta-analyses of microarray gene-expression datasets, a threshold value of correlation coefficients for gene-expression levels is used to decide whether gene-expression levels are strongly correlated across studies.
Yuan Ji, Chunlei Wu, Ping Liu, Jing Wang 0006, Kevin R. Coombes   +4 more
openaire   +3 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source