Results 51 to 60 of about 533,253 (261)
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
From Solvable to Executable Models of Biological Systems [PDF]
, 2008 Classical modeling approaches for biology are mainly grounded in mathematics, and specifically on ordinary differential equations (ODE). Process calculi-based conceptual and computational tools are an alternative and emergent approach.
Palmisano, Alida, Priami, Corrado
core
Closure-Free Functional Programming in a Two-Level Type Theory
Proc. ACM Program. Lang.Many abstraction tools in functional programming rely heavily on general-purpose compiler optimization to achieve adequate performance. For example, monadic binding is a higher-order function which yields runtime closures in the absence of sufficient ...
András Kovács
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Object-Oriented Programming in the Beta Programming Language [PDF]
, 1993 This is a book on object-oriented programming and the BETA programming language. Object-oriented programming originated with the Simula languages developed at the Norwegian Computing Center, Oslo, in the 1960s. The first Simula language, Simula I, was intended for writing simulation programs.
Madsen, Ole Lehrmann +2 more
openaire
Component-based simulation for a reconfiguration study of transitic systems [PDF]
, 2004 This paper is organized as follows. Part A presents the context of reconfiguring transitic systems and the main idea in implementing the decision step. It comprises sections 1 to 3. Section 3 presents an example that illustrates the concepts presented in
Berruet, Pascal +2 more
core +5 more sources
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
TRIQS: A Toolbox for Research on Interacting Quantum Systems [PDF]
, 2015 We present the TRIQS library, a Toolbox for Research on Interacting Quantum Systems. It is an open-source, computational physics library providing a framework for the quick development of applications in the field of many-body quantum physics, and in ...
Ayral, Thomas +6 more
core +5 more sources
Frontiers in Pharmacology, 2013 According to the amyloid hypothesis, Alzheimer Disease results from the accumulation beyond normative levels of the peptide amyloid-β (Aβ). Perhaps because of its pathological potential, Aβ and the enzymes that produce it are heavily regulated by the ...
T. Anastasio
semanticscholar +1 more source