Results 261 to 270 of about 40,118 (285)
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Accelerated atherosclerosis in beta-thalassemia
American Journal of Physiology-Heart and Circulatory Physiology, 2023This work definitively shows for the first time that beta-thalassemia leads to accelerated atherosclerosis. We demonstrated that intravascular hemolysis is a prominent feature in beta-thalassemia and the resulting increases in free heme are mechanistically relevant.
Julian Hurtado +8 more
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Platyspondyly in treated beta-thalassemia
European Journal of Radiology, 1994Flattening of the vertebral bodies with a platyspondyly appearance is described in 14 patients selected for evaluation of short stature from 106 patients affected by thalassemia major, who received an intensive transfusion regimen combined with continuous chelation therapy.
Scutellari Pn +2 more
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Neurological complications of beta-thalassemia
Annals of Hematology, 2015The thalassemias are the most common single gene disorder in the world. Over the last years, several reports have demonstrated neurological complications in beta-thalassemia patients. In most cases, these complications remained subclinical and were detected only during neuropsychological, neurophysiological, or neuroimaging evaluation.
P. Nemtsas +4 more
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Hematology/Oncology Clinics of North America, 2023
This article reviews the classification of beta-thalassemia syndromes, correlating clinical severity and genotype in the earlier classification, and broadening it recently based on clinical severity and transfusion status. The classification is dynamic, and individuals may progress from transfusion-independent to transfusion-dependent.
Morgan, Pines, Sujit, Sheth
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This article reviews the classification of beta-thalassemia syndromes, correlating clinical severity and genotype in the earlier classification, and broadening it recently based on clinical severity and transfusion status. The classification is dynamic, and individuals may progress from transfusion-independent to transfusion-dependent.
Morgan, Pines, Sujit, Sheth
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β-Thalassemia Mutations in Corsica
Hemoglobin, 2000Screening of beta thalassemia mutations in Corsica.
Varesi L +4 more
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The Silent Carrier of Beta Thalassemia
New England Journal of Medicine, 1969Abstract A family of Albanian descent had an unusual form of beta thalassemia. The father of two children with mild thalassemia major had normal red-cell morphology and normal levels of hemoglobins A2 and F, whereas the mother had elevated hemoglobin A2.
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Hemoglobin, 1990
Analyses of DNA from 64 patients with thalassemia major using the hybridization technique of amplified DNA with radiolabeled synthetic oligonucleotide probes identified 13 different beta-thalassemia mutations. The codon 39 (C----T) and IVS-I-110 (G----A) mutations occurred most frequently but seven additional mutations were observed which were present ...
G. H. Petkov +12 more
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Analyses of DNA from 64 patients with thalassemia major using the hybridization technique of amplified DNA with radiolabeled synthetic oligonucleotide probes identified 13 different beta-thalassemia mutations. The codon 39 (C----T) and IVS-I-110 (G----A) mutations occurred most frequently but seven additional mutations were observed which were present ...
G. H. Petkov +12 more
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Hemoglobin, 1990
A review is presented of the various beta-thalassemia alleles observed in nearly 191 patients with beta-thalassemia major and their 182 heterozygous relatives. Determination was by gene amplification and dot-blot hybridization with synthetic probes, specific for 27 different mutations.
R. Öner +9 more
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A review is presented of the various beta-thalassemia alleles observed in nearly 191 patients with beta-thalassemia major and their 182 heterozygous relatives. Determination was by gene amplification and dot-blot hybridization with synthetic probes, specific for 27 different mutations.
R. Öner +9 more
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Beta-Thalassemia Syndromes and Pregnancy
Obstetrical & Gynecological Survey, 1994The literature relating to homozygous beta-thalassemia and the problems these patients have during their pregnancy is reviewed and another case report of a twin pregnancy in a homozygous beta-thalassemia individual is included. The majority of cases described refer to the intermedia clinical form of the hematological problem because patients with ...
Charles Savona-Ventura, F. Bonello
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Gene addition for beta thalassemia
Annals of the New York Academy of Sciences, 2023AbstractIndividuals with transfusion‐dependent beta thalassemia require a high burden of care and experience significant morbidity from the underlying disease and its treatment, which negatively impact the quality of life. Allogeneic hematopoietic stem cell transplantation offers the chance for a cure, but donor availability and transplant‐related ...
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