Results 1 to 10 of about 82,601 (269)

Therapeutic Potential of Cytoglobin and Neuroglobin in Oxidative Stress-Driven Liver Diseases [PDF]

Antioxidants
Chronic liver diseases, including fibrosis and hepatocellular carcinoma (HCC), are primarily driven by oxidative stress, yet traditional antioxidant therapies often lack the specificity and efficacy required for clinical success.
Le Thi Thanh Thuy, Hoang Hai, Pham Tuan Anh, Nguyen Bui Tam Chi, Tran Van Bao, Tran Dang Anh Huyen, Nguyen Tran Quang Sang, Michelle L. Hermiston   +7 more
doaj   +2 more sources

RETROSPECTIVE ANALYSIS OF ALPHA GLOBIN COPY NUMBER VARIATIONS DETERMINED BY MLPA IN THE TRAKYA REGION

İstanbul Tıp Fakültesi Dergisi, 2021
Objective: Alpha thalassemia is a common type of hemoglobinopathy that occurs as a result of deletions or point mutations in the alpha globin gene cluster.
Selma Demir, Hakan Gürkan, Damla Eker, Sinem Yalçıntepe, Emine İkbal Atlı, Engin Atlı   +5 more
doaj   +1 more source

Gene Mutation Spectrum among Alpha-Thalassaemia Patients in Northeast Peninsular Malaysia

Diagnostics, 2023
(1) Background: Alpha (α)-thalassaemia is a genetic disorder that affects 5% of the world population. Deletional or nondeletional mutations of one or both HBA1 and HBA2 on chromosome 16 will result in reduced production of α-globin chains, a component of
Divashini Vijian, Wan Suriana Wan Ab Rahman, Kannan Thirumulu Ponnuraj, Zefarina Zulkafli, Rosnah Bahar, Norafiza Yasin, Syahzuwan Hassan, Ezalia Esa   +7 more
doaj   +1 more source

Androglobin, a chimeric mammalian globin, is required for male fertility

eLife, 2022
Spermatogenesis is a highly specialized differentiation process driven by a dynamic gene expression program and ending with the production of mature spermatozoa.
Anna Keppner, Miguel Correia, Sara Santambrogio, Teng Wei Koay, Darko Maric, Carina Osterhof, Denise V Winter, Angèle Clerc, Michael Stumpe, Frédéric Chalmel, Sylvia Dewilde, Alex Odermatt, Dieter Kressler, Thomas Hankeln, Roland H Wenger, David Hoogewijs   +15 more
doaj   +1 more source

Iron Metabolism in Normal and Pathological Pregnancies and Fetal Consequences

Metabolites, 2022
Iron is required for energy production, DNA synthesis, and cell proliferation, mainly as a component of the prosthetic group in hemoproteins and as part of iron-sulfur clusters.
Charles Mégier, Katell Peoc’h, Vincent Puy, Anne-Gaël Cordier   +3 more
doaj   +1 more source

An O2-sensing diguanylate cyclase broadly affects the aerobic transcriptome in the phytopathogen Pectobacterium carotovorum

Frontiers in Microbiology, 2023
Pectobacterium carotovorum is an important plant pathogen responsible for the destruction of crops through bacterial soft rot, which is modulated by oxygen (O2) concentration. A soluble globin coupled sensor protein, Pcc DgcO (also referred to as PccGCS)
Florian J. Fekete, Nick J. Marotta, Xuanyu Liu, Emily E. Weinert, Emily E. Weinert   +4 more
doaj   +1 more source

MiR-144 Regulates Hemoglobin Expression in Human Erythroid Cell Line

Walailak Journal of Science and Technology, 2020
The regulation of globin gene expression is significantly important to understand the pathogenesis of globin gene disorders. Recent findings have shown that microRNAs (miRNAs, miRs) play an important role in the regulation of globin gene expression. The
Tipparat PENGLONG, Apisara SAENSUWANNA, Jitpanu KOCHAROENWAT, Wittawat BOORINTARAGOT, Suppanut FUPONGSIRIPHAN, Kanitta SRINOUN   +5 more
doaj   +3 more sources

A simple, highly efficient method for heterologous expression in mammalian primary neurons using cationic lipid-mediated mRNA transfection

Frontiers in Neuroscience, 2010
Expression of heterologous proteins in adult mammalian neurons is a valuable technique for the study of neuronal function. The postmitotic nature of mature neurons prevents effective DNA transfection using simple, cationic lipid-based methods.
Damian J Williams, Henry L Puhl, Stephen R Ikeda   +2 more
doaj   +1 more source

TFII-I/Gtf2i and Erythro-Megakaryopoiesis

Frontiers in Physiology, 2020
TFII-I is a ubiquitously expressed transcription factor that positively or negatively regulates gene expression. TFII-I has been implicated in neuronal and immunologic diseases as well as in thymic epithelial cancer.
Aishwarya Gurumurthy, Qiong Wu, Rukiye Nar, Kimberly Paulsen, Alexis Trumbull, Ryan C. Fishman, Marjorie Brand, John Strouboulis, Zhijian Qian, Jörg Bungert   +9 more
doaj   +1 more source

Distribution of cytoglobin in the mouse brain

Frontiers in Neuroanatomy, 2016
Cytoglobin (Cygb) is a vertebrate globin with so far poorly defined function. It is expressed in the fibroblast cell-lineage but has also been found in neurons.
Stefan eReuss, Sylvia eWystub, Ursula eDisque-Kaiser, Thomas eHankeln, Thorsten eBurmester   +4 more
doaj   +1 more source