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Stress Erythropoiesis is a Key Inflammatory Response [PDF]
Cells, 2020 Bone marrow medullary erythropoiesis is primarily homeostatic. It produces new erythrocytes at a constant rate, which is balanced by the turnover of senescent erythrocytes by macrophages in the spleen.
Robert Paulson, Paulson Robert F
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Erythropoiesis and Malaria, a Multifaceted Interplay [PDF]
International Journal of Molecular Sciences, 2022 One of the major pathophysiologies of malaria is the development of anemia. Although hemolysis and splenic clearance are well described as causes of malarial anemia, abnormal erythropoiesis has been observed in malaria patients and may contribute ...
Catherine Lavazec, Lavazec Catherine
exaly +3 more sources
Metabolic regulation of stress erythropoiesis, outstanding questions, and possible paradigms
Frontiers in Physiology, 2023 Steady state erythropoiesis produces new erythrocytes at a constant rate to replace the senescent cells that are removed by macrophages in the liver and spleen.
Baiye Ruan +2 more
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Molecular mechanisms of regulation of erythropoiesis and stress erythropoiesis [PDF]
Medicinski PodmladakErythropoiesis under basal conditions involves the continuous production of new erythrocytes at a constant rate. During the adult period, erythropoiesis takes place primarily in the bone marrow and has a substantial capacity.
Momčilović Sanja +2 more
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Networking erythropoiesis [PDF]
Journal of Experimental Medicine, 2010 A relatively small cadre of lineage-restricted transcription factors largely orchestrates erythropoiesis, but how these nuclear factors interact to regulate this complex biology is still largely unknown. However, recent technological advances, such as chromatin immunoprecipitation (ChIP) paired with massively parallel sequencing (ChIP-seq), gene ...
Kerenyi, Marc A., Orkin, Stuart
openaire +7 more sources
Erythropoiesis: insights into pathophysiology and treatments in 2017
Molecular Medicine, 2018 Erythropoiesis is a tightly-regulated and complex process originating in the bone marrow from a multipotent stem cell and terminating in a mature, enucleated erythrocyte.
Andrea Zivot +3 more
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Oxidation and erythropoiesis [PDF]
Current Opinion in Hematology, 2019 Purpose of review Erythropoiesis is a complex multistep process going from committed erythroid progenitors to mature red cells. Although recent advances allow the characterization of some components of erythropoiesis, much still remains to be investigated particularly on stress erythropoiesis.
Matte A., De Franceschi L.
openaire +5 more sources
Macrophages support splenic erythropoiesis in 4T1 tumor-bearing mice. [PDF]
PLoS ONE, 2015 Anemia is a common complication of cancer; a role of spleen in tumor-stress erythropoiesis has been suggested. However, the molecular mechanisms involved in the splenic erythropoiesis following tumor maintenance remain poorly understood.
Min Liu +5 more
doaj +3 more sources
Transferrin Receptors in Erythropoiesis [PDF]
International Journal of Molecular Sciences, 2020 Erythropoiesis is a highly dynamic process giving rise to red blood cells from hematopoietic stem cells present in the bone marrow. Red blood cells transport oxygen to tissues thanks to the hemoglobin comprised of α- and β-globin chains and of iron ...
Cyrielle Richard, F. Verdier
semanticscholar +2 more sources
Regulation of erythropoiesis: emerging concepts and therapeutic implications
Hematology, 2023 The process of erythropoiesis is complex and involves the transfer of cells from the yolk sac to the fetal hepar and, ultimately, to the bone marrow during embryonic development.
P. Tang, Huaquan Wang
semanticscholar +1 more source