Results 11 to 20 of about 85,932 (276)
IL-10 Plays a Critical Role in Mitigating Acute Anaemia Development During African Trypanosome Infection [PDF]
PathogensDuring the first week of T. b. brucei infection, pro-inflammatory IFN-γ production drives acute anaemia by promoting red blood cell clearance by activated macrophages in concert with insufficient bone marrow compensation.
Maida Živalj +9 more
doaj +2 more sources
Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation [PDF]
Nature Cell Biology, 2017 Advances in genomic profiling present new challenges of explaining how changes in DNA and RNA are translated into proteins linking genotype to phenotype.
Xin Liu, Yuannyu Zhang, Min Ni
exaly +3 more sources
G-CSF shifts erythropoiesis from bone marrow into spleen in the setting of systemic inflammation
Life Science Alliance, 2021 Granulocyte colony-stimulating factor suppresses erythropoiesis of bone marrow and promotes splenic erythropoiesis during lipopolysaccharide-induced systemic inflammation in mice.
Weiqiang Jing +9 more
doaj +1 more source
Frontiers in Immunology, 2023 Splenomegaly is a prominent clinical manifestation of malaria and the causes remain incompletely clear. Anemia is induced in malaria and extramedullary splenic erythropoiesis is compensation for the loss of erythrocytes.
Jiajie Li +18 more
doaj +1 more source
Networking erythropoiesis [PDF]
Journal of Experimental Medicine, 2010 A relatively small cadre of lineage-restricted transcription factors largely orchestrates erythropoiesis, but how these nuclear factors interact to regulate this complex biology is still largely unknown. However, recent technological advances, such as chromatin immunoprecipitation (ChIP) paired with massively parallel sequencing (ChIP-seq), gene ...
Kerenyi, Marc A., Orkin, Stuart
openaire +3 more sources
Metabolic regulation of stress erythropoiesis, outstanding questions, and possible paradigms
Frontiers in Physiology, 2023 Steady state erythropoiesis produces new erythrocytes at a constant rate to replace the senescent cells that are removed by macrophages in the liver and spleen.
Baiye Ruan +2 more
doaj +1 more source
MIF contributes to Trypanosoma brucei associated immunopathogenicity development [PDF]
, 2014 African trypanosomiasis is a chronic debilitating disease affecting the health and economic well-being of many people in developing countries. The pathogenicity associated with this disease involves a persistent inflammatory response, whereby M1-type ...
Beschin, Alain +11 more
core +9 more sources
Post-transcriptional regulation of erythropoiesis
Blood Science, 2023 Erythropoiesis is a complex, precise, and lifelong process that is essential for maintaining normal body functions. Its strict regulation is necessary to prevent a variety of blood diseases.
Yanan Li +5 more
doaj +1 more source
Macrophages support splenic erythropoiesis in 4T1 tumor-bearing mice. [PDF]
PLoS ONE, 2015 Anemia is a common complication of cancer; a role of spleen in tumor-stress erythropoiesis has been suggested. However, the molecular mechanisms involved in the splenic erythropoiesis following tumor maintenance remain poorly understood.
Min Liu +5 more
doaj +1 more source
Stress Erythropoiesis is a Key Inflammatory Response
Cells, 2020 Bone marrow medullary erythropoiesis is primarily homeostatic. It produces new erythrocytes at a constant rate, which is balanced by the turnover of senescent erythrocytes by macrophages in the spleen.
Robert F. Paulson +3 more
doaj +1 more source