Results 21 to 30 of about 85,288 (249)
Stem Cell Reports, 2021 Summary We document here that intensive care COVID-19 patients suffer a profound decline in hemoglobin levels but show an increase of circulating nucleated red cells, suggesting that SARS-CoV-2 infection either directly or indirectly induces stress ...
Hector Huerga Encabo +10 more
semanticscholar +1 more source
Dapagliflozin Suppresses Hepcidin And Increases Erythropoiesis.
Journal of Clinical Endocrinology and Metabolism, 2020 CONTEXT Dapagliflozin and other SGLT2 inhibitors are known to increase hematocrit possibly due to it diuretic effects and hemoconcentration. OBJECTIVE Since type 2 diabetes is a pro-inflammatory state and since hepcidin, a known suppressor of ...
H. Ghanim +7 more
semanticscholar +1 more source
Development of luspatercept to treat ineffective erythropoiesis.
Blood Advances, 2021 Luspatercept (Reblozyl) was recently approved for treating patients with transfusion-dependent lower-risk myelodysplastic syndrome (MDS) with ring sideroblasts (RS) and/or SF3B1 mutation who were not eligible for erythropoiesis-stimulating agents (ESAs ...
A. Kubasch, P. Fenaux, U. Platzbecker
semanticscholar +1 more source
Embryonal erythropoiesis and aging exploit ferroptosis
Redox Biology, 2021 Ferroptosis is a form of regulated cell necrosis, as a consequence of Fe(II)-dependent lipid peroxidation. Although ferroptosis has been linked to cancer cell death, neurodegeneration and reperfusion injury, physiological roles of ferroptosis have not ...
Hao Zheng +4 more
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2021 Erythroblastic islands (EBIs), discovered more than 60 years ago, are specialized microenvironments for erythropoiesis. This island consists of a central macrophage with surrounding developing erythroid cells.
Wei Li +3 more
semanticscholar +1 more source
Erythropoiesis in health and disease: Distinguishing defective and ineffective erythropoiesis. [PDF]
HemasphereErythropoiesis is a finely regulated process ensuring continuous red blood cell production to maintain oxygen delivery. Disruptions in this process give rise to defective erythropoiesis, characterized by impaired lineage commitment and progenitor ...
El Hoss S +3 more
europepmc +2 more sources
American journal of hematology/oncology, 2021 Identification of stage‐specific erythroid cells is critical for studies of normal and disordered human erythropoiesis. While immunophenotypic strategies have previously been developed to identify cells at each stage of terminal erythroid differentiation,
Hongxia Yan +13 more
semanticscholar +1 more source
Haematologica, 2023 Enhancer of zeste homolog 2 (EZH2) is the lysine methyltransferase of polycomb repressive complex 2 (PRC2) that catalyzes H3K27 tri-methylation. Aberrant expression and loss-of-function mutations of EZH2 have been demonstrated to be tightly associated ...
Mengjia Li +13 more
doaj +1 more source
Frontiers in Physiology, 2018 RASA3 is a Ras GTPase activating protein that plays a critical role in blood formation. The autosomal recessive mouse model scat (severe combined anemia and thrombocytopenia) carries a missense mutation in Rasa3.
Emily S. Hartman +8 more
doaj +1 more source
Research advances in erythrocyte regeneration sources and methods in vitro
Cell Regeneration, 2018 Erythrocytes (red blood cells, RBCs) facilitate gas exchange in the lungs and transport oxygen to the tissues. The human body must maintain erythrocyte regeneration to support metabolically active cells and tissues.
Shuming Sun, Yuanliang Peng, Jing Liu
doaj +1 more source