Results 21 to 30 of about 85,932 (276)

Role of Cytokine-Inducible SH2 Domain-Containing (CISH) Protein in the Regulation of Erythropoiesis

Biomolecules, 2023
The cytokine-inducible SH2 domain-containing (CISH) protein was the first member of the suppressor of cytokine signaling (SOCS) family of negative feedback regulators discovered, being identified in vitro as an inducible inhibitor of erythropoietin (EPO)
Saeed Maymand, Asha L. Lakkavaram, Wasan Naser, Parisa Rasighaemi, Daniel Dlugolenski, Clifford Liongue, John Stambas, Tania F. de Koning-Ward, Alister C. Ward   +8 more
doaj   +1 more source

Increased hepcidin in transferrin-treated thalassemic mice correlates with increased liver BMP2 expression and decreased hepatocyte ERK activation

Haematologica, 2016
Iron overload results in significant morbidity and mortality in β-thalassemic patients. Insufficient hepcidin is implicated in parenchymal iron overload in β-thalassemia and approaches to increase hepcidin have therapeutic potential.
Huiyong Chen, Tenzin Choesang, Huihui Li, Shuming Sun, Petra Pham, Weili Bao, Maria Feola, Mark Westerman, Guiyuan Li, Antonia Follenzi, Lionel Blanc, Stefano Rivella, Robert E. Fleming, Yelena Z. Ginzburg   +13 more
doaj   +1 more source

The role of cyclic nucleotide on fetal and neonantal erythropoiesis [PDF]

, 1974
For the purpose to reveal the changes in stimulatory effect of dibutyryl-cyclic- AMP on erythropoiesis during ontogenetic development, the author studied syntheses of DNA, RNA and protein of erythroid cells in fetal liver, neonatal and adult bone marrows
Tada, Hiroshi
core   +1 more source

Erythropoiesis: insights into pathophysiology and treatments in 2017

Molecular Medicine, 2018
Erythropoiesis is a tightly-regulated and complex process originating in the bone marrow from a multipotent stem cell and terminating in a mature, enucleated erythrocyte.
Andrea Zivot, Jeffrey M. Lipton, Anupama Narla, Lionel Blanc   +3 more
doaj   +1 more source

Identification of erythroferrone as an erythroid regulator of iron metabolism. [PDF]

, 2014
Recovery from blood loss requires a greatly enhanced supply of iron to support expanded erythropoiesis. After hemorrhage, suppression of the iron-regulatory hormone hepcidin allows increased iron absorption and mobilization from stores.
Ganz, Tomas, Jung, Grace, Kautz, Léon, Nemeth, Elizabeta, Rivella, Stefano, Valore, Erika V   +5 more
core   +1 more source

Increased Reactive Oxygen Species and Cell Cycle Defects Contribute to Anemia in the RASA3 Mutant Mouse Model scat

Frontiers in Physiology, 2018
RASA3 is a Ras GTPase activating protein that plays a critical role in blood formation. The autosomal recessive mouse model scat (severe combined anemia and thrombocytopenia) carries a missense mutation in Rasa3.
Emily S. Hartman, Elena C. Brindley, Elena C. Brindley, Julien Papoin, Steven L. Ciciotte, Yue Zhao, Luanne L. Peters, Lionel Blanc, Lionel Blanc   +8 more
doaj   +1 more source

Stage-specific dual function: EZH2 regulates human erythropoiesis by eliciting histone and non-histone methylation

Haematologica, 2023
Enhancer of zeste homolog 2 (EZH2) is the lysine methyltransferase of polycomb repressive complex 2 (PRC2) that catalyzes H3K27 tri-methylation. Aberrant expression and loss-of-function mutations of EZH2 have been demonstrated to be tightly associated ...
Mengjia Li, Donghao Liu, Fumin Xue, Hengchao Zhang, Qianqian Yang, Lei Sun, Xiaoli Qu, Xiuyun Wu, Huizhi Zhao, Jing Liu, Qiaozhen Kang, Ting Wang, Xiuli An, Lixiang Chen   +13 more
doaj   +1 more source

Decoding erythropoiesis [PDF]

Blood, 2017
In this issue of Blood, Alvarez-Dominguez et al reveal the strategies used to achieve precise but highly dynamic translational control of protein synthesis during red blood cell development.
openaire   +3 more sources

Research advances in erythrocyte regeneration sources and methods in vitro

Cell Regeneration, 2018
Erythrocytes (red blood cells, RBCs) facilitate gas exchange in the lungs and transport oxygen to the tissues. The human body must maintain erythrocyte regeneration to support metabolically active cells and tissues.
Shuming Sun, Yuanliang Peng, Jing Liu
doaj   +1 more source

Suppression of erythropoiesis by actinomycin D. 3. The effect of actinomycin D on the hemoglobin level of bone marrow erythrocytes and erythroblasts [PDF]

, 1969
For the purpose of revealing whether or not hemoglobin synthesis is inhibited by the AMD, the author estimated the hemoglobin level of AMD treated anilmals by microspectrophotometer, and found that the hemoglobin levels of all the developmental stages of
Okada, Shigeru
core   +1 more source