Results 41 to 50 of about 82,601 (269)
Globin genes on the move [PDF]
Journal of Biology, 2008 Recent data published in BMC Biology from the globin gene clusters in platypus, together with data from other species, show that beta-globin genes transposed from one chromosomal location to another. This resolves some controversies about vertebrate globin gene evolution but ignites new ones.
openaire +2 more sources
A dual reporter mouse model of the human β-globin locus: applications and limitations. [PDF]
PLoS ONE, 2012 The human β-globin locus contains the β-like globin genes (i.e. fetal γ-globin and adult β-globin), which heterotetramerize with α-globin subunits to form fetal or adult hemoglobin.
Petros Papadopoulos +8 more
doaj +1 more source
The diversity of globin‐coupled sensors [PDF]
FEBS Letters, 2003 The recently discovered globin‐coupled sensors (GCSs) are heme‐containing two‐domain transducers distinct from the PAS domain superfamily. We have identified an additional 22 GCSs with varying multi‐domain C‐terminal transmitters through a search of the complete and incomplete microbial genome datasets.
Freitas, Tracey Allen K +2 more
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Krüppel-Like Transcription Factor KLF1 Is Required for Optimal γ- and β-Globin Expression in Human Fetal Erythroblasts. [PDF]
PLoS ONE, 2016 In human adult erythroid cells, lower than normal levels of Krüppel-like transcription factor 1 (KLF1) are generally associated with decreased adult β- and increased fetal γ-globin gene expression. KLF1 also regulates BCL11A, a known repressor of adult γ-
Divya S Vinjamur +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao +3 more
wiley +1 more source
, 2016 Study population and distribution of C. trachomatis positive smears between cases and controls, for all β-globin-positive smears collected in the study.
Sandrine McKay-Chopin (251858) +7 more
core +1 more source
The role of WDR5 in silencing human fetal globin gene expression
Haematologica, 2012 Background Histone H3 lysine 4 (K4) methylation has been linked with transcriptional activity in mammalian cells. The WD40-repeat protein, WDR5, is an essential component of the MLL complex that induces histone H3 K4 methylation, but the role of WDR5 in ...
Zhen Xu +9 more
doaj +1 more source
Reactivation of a developmentally silenced embryonic globin gene
Nature Communications, 2021 Globin loci harbor genes that are expressed embryonically and silenced postnatally. Here the authors show that zeta-globin silencing depends upon selective hypoacetylation of its TAD subdomain, which blocks its interaction with the alpha-globin super ...
Andrew J. King +25 more
doaj +1 more source
Physiological and Aberrant γ-Globin Transcription During Development
Frontiers in Cell and Developmental Biology, 2021 The expression of the fetal Gγ- and Aγ-globin genes in normal development is confined to the fetal period, where two γ-globin chains assemble with two α-globin chains to form α2γ2 tetramers (HbF). HbF sustains oxygen delivery to tissues until birth, when
Gloria Barbarani +4 more
doaj +1 more source
Advanced Science, EarlyView.This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li +15 more
wiley +1 more source