Results 21 to 30 of about 82,601 (269)

Upregulation of alpha globin promotes apoptotic cell death in the hematopoietic cell line FL5.12 [PDF]

, 2004
The function of alpha globin in the context of oxygen transport in erythroid cells is well described. There is growing evidence, however, that alpha globin is involved in processes other than tissue oxygen supply.
Brecht, Karin
core   +1 more source

The folding pathway for globins [PDF]

FEBS Letters, 1977
Previous investigations have successfully predicted the three-dimensional structures of trypsin inhibitor [ 1,2] , myoglobin [3,4] , TMV protein [ 51 and rubredoxin [2]. Using mechanisms of protein chain folding which one of us [5 $1 suggested,.we can find a common folding pathway for the globins which are included in the ‘Atlas of Protein Sequence and
Lim, V.I., Efimov, A.V.
openaire   +2 more sources

Isolation, characterization and immunolocalization of a globin-like antigen from Ostertagia ostertagi adults [PDF]

, 1996
Western blot analysis using an anti-globin rabbit serum Rb94 revealed a major band of 17 kDa in extracts of Ostertagia ostertagi adults and 4th-stage larvae.
De Marez, Tine, Blaxter, Mark L, Berghen, Paul, Raes, Stefaan, Blaxter, M. L., de Marez, T. M., Berghen, P., de Marez, T.M., Vercruysse, J., de Graaf, Dirk, Raes, S., Vercruysse, Jozef, Moens, L., de Graaf, D.C., Moens, Luc, Blaxter, M.L., de Graaf, D. C.   +16 more
core   +1 more source

Genetic and Epigenetic Therapies for β-Thalassaemia by Altering the Expression of α-Globin Gene

Frontiers in Genome Editing, 2021
β-Thalassaemia is caused by over 300 mutations in and around the β-globin gene that lead to impaired synthesis of β-globin. The expression of α-globin continues normally, resulting in an excess of α-globin chains within red blood cells and their ...
Sachith Mettananda, Sachith Mettananda
doaj   +1 more source

Nerve Globins in Invertebrates

IUBMB Life, 2004
AbstractThe expression of nerve hemoglobins in invertebrates is a well‐established fact, but this occurrence is uncommon. In the species where nerve globins occur, they probably function as an oxygen store for sustaining activity of the nerves during anoxic conditions.
GEUENS E., DEWILDE S., HOOGEWIJS D., PESCE, ALESSANDRA, NIENHAUS K., NIENHAUS G. U., OLSON J., VANFLETEREN J., BOLOGNESI, MARTINO, MOENS L.   +9 more
openaire   +5 more sources

A etimologia de biomoléculas com metais de transição como auxiliar na aprendizagem de Química Biológica

Química Nova, 2013
Numerous functional biomolecules are associated with metals, i.e. the metallobiomolecules; more specifically, some are dependent on transition metals required for several crucial biological roles.
José A. L. da Silva
doaj   +1 more source

ATF4 Regulates MYB to Increase γ-Globin in Response to Loss of β-Globin

Cell Reports, 2020
Summary: β-Hemoglobinopathies can trigger rapid production of red blood cells in a process known as stress erythropoiesis. Cellular stress prompts differentiating erythroid precursors to express high levels of fetal γ-globin.
Mandy Y. Boontanrart, Markus S. Schröder, Gautier M. Stehli, Marija Banović, Stacia K. Wyman, Rachel J. Lew, Matteo Bordi, Benjamin G. Gowen, Mark A. DeWitt, Jacob E. Corn   +9 more
doaj   +1 more source

Prevalence and genetic analysis of triplicated α-globin gene in Ganzhou region using high-throughput sequencing

Frontiers in Genetics, 2023
α-globin gene triplication carriers were not anemic in general, while some studies found that α-globin gene triplication coinherited with heterozygous β-thalassemia may cause adverse clinical symptoms, which yet lacks sufficient evidence in large ...
Xinxing Xie, Jinhui Gan, Zezhang Liu, Zezhang Liu, Yulian Zhou, Kun Yuan, Kun Yuan, Zhigang Chen, Zhigang Chen, Shiping Chen, Rui Zhou, Rui Zhou, Lipei Liu, Lipei Liu, Xiaoyan Huang, Yan Zhang, Yan Zhang, Qian Liu, Qian Liu, Wenqian Zhang, Wenqian Zhang, Jungao Huang, Junkun Chen   +22 more
doaj   +1 more source

A phylogenomic profile of globins [PDF]

BMC Evolutionary Biology, 2006
AbstractBackgroundGlobins occur in all three kingdoms of life: they can be classified into single-domain globins and chimeric globins. The latter comprise the flavohemoglobins with a C-terminal FAD-binding domain and the gene-regulating globin coupled sensors, with variable C-terminal domains.
Vinogradov, S. N., Hoogewijs, D., Bailly, X., Arredondo-Peter, R., Gough, Julian J T, Dewilde, S., Moens, L., Vanfleteren, J. R.   +7 more
openaire   +7 more sources

3,3′,5-Triiodothyroacetic acid (TRIAC) induces embryonic ζ-globin expression via thyroid hormone receptor α

Journal of Hematology & Oncology, 2021
The human ζ-globin gene (HBZ) is transcribed in primitive erythroid cells only during the embryonic stages of development. Reactivation of this embryonic globin synthesis would likely alleviate symptoms both in α-thalassemia and sickle-cell disease ...
Huiqiao Chen, Zixuan Wang, Shanhe Yu, Xiao Han, Yun Deng, Fuhui Wang, Yi Chen, Xiaohui Liu, Jun Zhou, Jun Zhu, Hao Yuan   +10 more
doaj   +1 more source