Results 21 to 30 of about 136,712 (243)
Journal of Hematology & Oncology, 2021 The human ζ-globin gene (HBZ) is transcribed in primitive erythroid cells only during the embryonic stages of development. Reactivation of this embryonic globin synthesis would likely alleviate symptoms both in α-thalassemia and sickle-cell disease ...
Huiqiao Chen +10 more
doaj +1 more source
Whole transcriptome analysis of human erythropoietic cells during ontogenesis suggests a role of VEGFA gene as modulator of fetal hemoglobin and pharmacogenomic biomarker of treatment response to hydroxyurea in β-type hemoglobinopathy patients [PDF]
, 2017 Background: Human erythropoiesis is characterized by distinct gene expression profiles at various developmental stages. Previous studies suggest that fetal-to-adult hemoglobin switch is regulated by a complex mechanism, in which many key players still ...
Ali, Bassam R. +11 more
core +5 more sources
Distribution of cytoglobin in the mouse brain
Frontiers in Neuroanatomy, 2016 Cytoglobin (Cygb) is a vertebrate globin with so far poorly defined function. It is expressed in the fibroblast cell-lineage but has also been found in neurons.
Stefan eReuss +4 more
doaj +1 more source
Globins in Caenorhabditis elegans
IUBMB Life, 2011 AbstractExtensive in silico search of the genome of Caenorhabditis elegans revealed the presence of 33 genes coding for globins that are all transcribed. These globins are very diverse in gene and protein structure and are localized in a variety of cells, mostly neurons. The large number of C.
Tilleman, L +8 more
openaire +5 more sources
Italian Journal of Animal Science, 2019 The feed utilisation of young chicks is characterised by a suboptimal fat digestibility, which can be improved by means of dietary emulsifiers. The objective of this study was to evaluate the effect of dietary Globin on the energy efficiency and ...
Sihem Dabbou +11 more
doaj +1 more source
Gelling Properties of Globin-Succinylated Globin Conjugates.
NIPPON SHOKUHIN KOGYO GAKKAISHI, 1993 2種類のグロビン-サクシニル化グロビン複合体(CMHTとCUT)を調製し,各複合体のゲル特性について検討した.(1) CMHTはGの配合比率が高くなる程ゲル形成pHは中性の方へ拡大した.例えば, GとSGの配合率が3:7の場合,ゲル形成pHは2.0であったが,G:SG=9:1の場合,ゲルはpH 2.0～3.5の範囲で形成された.一方, G:SGの配合比率が7:3と9:1のCUTの場合,ゲル形成pHは極めて狭い範囲に限定された.(2) ゲルの透明度はCMHT, CUTともにより酸性側で高く,また,グロビンの配合比率が高くなる程透明度も高くなる傾向を示した.(3) 複合体ゲルのゲル強度を測定した. CMHTの場合, G:SG=5:5 (pH 2.0)で高いゲル強度が得られた.
Yuji MIYAGUCHI +4 more
openaire +2 more sources
Primitive and definitive erythropoiesis in mammals
Frontiers in Physiology, 2014 Red blood cells (RBCs), which constitute the most abundant cell type in the body, come in two distinct flavors- primitive and definitive. Definitive RBCs in mammals circulate as smaller, anucleate cells during fetal and postnatal life, while primitive ...
James ePalis
doaj +1 more source
Cryptic transcripts from a ubiquitous plasmid origin of replication confound tests for cis-regulatory function. [PDF]
, 2012 A vast amount of research on the regulation of gene expression has relied on plasmid reporter assays. In this study, we show that plasmids widely used for this purpose constitutively produce substantial amounts of RNA from a TATA-containing cryptic ...
Hiraoka, Kei +3 more
core +2 more sources
Frontiers in Bioscience-LandmarkThis paper is dedicated to the memory of Oleg B. Ptitsyn (1929-1999) and presents an answer to his question: “What is the role of conserved non-functional residues in protein folding?”. This answer follows from the experimental works of three labs.
Valentina E. Bychkova +3 more
doaj +1 more source
Engineering Globin Gene Expression [PDF]
Molecular Therapy - Methods & Clinical Development, 2019 Hemoglobinopathies, including sickle cell disease and thalassemia, are among the most common inherited genetic diseases worldwide. Due to the relative ease of isolating and genetically modifying hematopoietic stem and progenitor cells, recent gene editing and gene therapy strategies have progressed to clinical trials with promising outcomes; however ...
Rachael Davis +4 more
openaire +3 more sources