Results 11 to 20 of about 94,653 (246)
Reactivation of a developmentally silenced embryonic globin gene [PDF]
Nature Communications, 2021 Globin loci harbor genes that are expressed embryonically and silenced postnatally. Here the authors show that zeta-globin silencing depends upon selective hypoacetylation of its TAD subdomain, which blocks its interaction with the alpha-globin super ...
Andrew J. King +25 more
doaj +2 more sources
Platypus globin genes and flanking loci suggest a new insertional model for beta-globin evolution in birds and mammals [PDF]
BMC Biology, 2008 Background Vertebrate alpha (α)- and beta (β)-globin gene families exemplify the way in which genomes evolve to produce functional complexity. From tandem duplication of a single globin locus, the α- and β-globin clusters expanded, and then were ...
Warren Wesley C +7 more
doaj +2 more sources
The globin gene family of the cephalochordate amphioxus: implications for chordate globin evolution [PDF]
BMC Evolutionary Biology, 2010 Background The lancelet amphioxus (Cephalochordata) is a close relative of vertebrates and thus may enhance our understanding of vertebrate gene and genome evolution.
Marden Michael C +6 more
doaj +4 more sources
A Globin in the Nucleus! [PDF]
Journal of Biological Chemistry, 2003 Cytoglobin and neuroglobin are recently discovered members of the globin family. In situ hybridization localized neuroglobin mainly in brain and retina, while cytoglobin was expressed ubiquitously in all analyzed tissues. In the present study, polyclonal antibodies were raised against both proteins and the distribution of them was studied by ...
Geuens, Eva +5 more
openaire +3 more sources
Regulation of the Globin Genes [PDF]
Pediatric Research, 2002 The a- and b-globin gene clusters are subject to several levels of regulation. They are expressed exclusively in the erythroid cells, only during defined periods of development and in a perfectly tuned way, assuring, at any stage of ontogeny, a correct balance in the availability of a- and b-globin chains for hemoglobin assembling. Such a tight control
Cao A, MOI, PAOLO
openaire +3 more sources
TMEM8 – a non-globin gene entrapped in the globin web [PDF]
Nucleic Acids Research, 2009 For more than 30 years it was believed that globin gene domains included only genes encoding globin chains. Here we show that in chickens, the domain of alpha-globin genes also harbor the non-globin gene TMEM8. It was relocated to the vicinity of the alpha-globin cluster due to inversion of an approximately 170-kb genomic fragment.
Philonenko, Elena S. +5 more
openaire +2 more sources
Phenotypic and Genotypic Analysis of Two Rare Cases of ‐‐SEA/‐α4.3HbH Disease [PDF]
J Clin Lab AnalWe report two unrelated adult patients with rare deletional HbH disease (genotype ‐‐SEA/‐α4.3). This novel 4.3 kb deletion covering the HBA1 gene is accompanied by X‐Y‐Z segment recombination, which was identified by CycloneSEQ long‐read nanopore sequencing.
Yang W +7 more
europepmc +2 more sources
Upregulation of alpha globin promotes apoptotic cell death in the hematopoietic cell line FL5.12 [PDF]
, 2004 The function of alpha globin in the context of oxygen transport in erythroid cells is well described. There is growing evidence, however, that alpha globin is involved in processes other than tissue oxygen supply.
Brecht, Karin
core +1 more source
Analysis of β-globin chromatin micro-environment using a novel 3C variant, 4Cv [PDF]
, 2010 Copyright: © 2010 Pink et al.Higher order chromatin folding is critical to a number of developmental processes, including the regulation of gene expression.
Christopher H Eskiw +17 more
core +1 more source
The role of non-coding RNAs in haemoglobin regulation [PDF]
, 2009 Non-coding RNAs appear to play a role in gene regulation by modulating chromatin structure. There is mounting evidence suggesting an essential role for non-coding RNAs in the complex process of the genetic regulation of the β-globin locus.
Trujillano Lidon, Daniel
core +3 more sources