Results 51 to 60 of about 94,653 (246)
Cell Reports, 2018 Summary: Fetal globin genes are transcriptionally silenced during embryogenesis through hemoglobin switching. Strategies to derepress fetal globin expression in the adult could alleviate symptoms in sickle cell disease and β-thalassemia.
Bjorg Gudmundsdottir +16 more
doaj +1 more source
A Novel High-Content Immunofluorescence Assay as a Tool to Identify at the Single Cell Level γ-Globin Inducing Compounds. [PDF]
PLoS ONE, 2015 The identification of drugs capable of reactivating γ-globin to ameliorate β-thalassemia and Sickle Cell anemia is still a challenge, as available γ-globin inducers still have limited clinical indications.
Marta Durlak +14 more
doaj +1 more source
Advanced Science, EarlyView.Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem +24 more
wiley +1 more source
Imbalanced globin chain synthesis determines erythroid cell pathology in thalassemic mice
Haematologica, 2009 Background β-thalassemia occurs from the imbalanced globin chain synthesis due to the absence or inadequate β-globin chain production. The excessive unbound α-globin chains precipitate in erythroid precursors and mature red blood cells leading to ...
Kanitta Srinoun +6 more
doaj +1 more source
MN•CS•IO System: Cross‐Species Study for HBB Function in High‐Altitude Hypoxia Adaptation
Advanced Science, EarlyView.We developed an integrative mesh‐nanorod sorting, chitosan nanoparticle delivery, and intraosseous injection (MN•CS•IO) system to investigate HBB in high‐altitude hypoxia adaptation. Transplanting Tibetan animals' HBB‐modified Lin‐ cells into mice achieved 95.59% transfection efficiency and 8.15% HBB expression. High‐altitude HBB recipients upregulated
Wenqiao Hui +18 more
wiley +1 more source
Ectopic MYBL2-Mediated Regulation of Androglobin Gene Expression
CellsAndroglobin (ADGB) is a highly conserved and recently identified member of the globin superfamily. Although previous studies revealed a link to ciliogenesis and an involvement in murine spermatogenesis, its physiological function remains mostly unknown ...
Antonia Herwig +6 more
doaj +1 more source
Regulation of Gγ-globin gene by ATF2 and its associated proteins through the cAMP-response element. [PDF]
PLoS ONE, 2013 The upstream Gγ-globin cAMP-response element (G-CRE) plays an important role in regulating Gγ-globin expression through binding of ATF2 and its DNA-binding partners defined in this study.
Li Liu +6 more
doaj +1 more source
, 2016 Study population and distribution of C. trachomatis positive smears between cases and controls, for all β-globin-positive smears collected in the study.
Sandrine McKay-Chopin (251858) +7 more
core +1 more source
Advanced Science, EarlyView.A living multi‐omics sarcoma PDX biobank is enriched for high‐risk disease and preserves key patient tumor features at histopathological and molecular levels. Integrated profiling reveals ecDNA‐driven oncogene amplification in osteosarcoma and preferential retention of ecDNA during PDX evolution.
Weisong Zhao +34 more
wiley +1 more source
Soluble and insoluble globin analyses.
, 2013 (A) Western blot analyses of globin chains were performed using total soluble cytosolic protein (20 µg/lane) from day 14, 18, and 21 cultured erythroblasts. Antibodies against alpha-globin, beta-globin, and gamma-globin were used for comparison.
Jaira F. de Vasconcellos (431552) +7 more
core +1 more source