Results 71 to 80 of about 136,712 (243)
Journal of Clinical Laboratory Analysis, EarlyView.Naganishia diffluens, a rare non‐neoformans cryptococcal species, was identified by PCR sequencing as the causative agent of oral cryptococcosis in a 31‐year‐old Iranian man with β‐thalassemia. This case represents the first documented instance of oral infection by N.
Zahra Yahyazadeh +13 more
wiley +1 more source
Erythroid-specific expression of β-globin from Sleeping Beauty-transduced human hematopoietic progenitor cells. [PDF]
PLoS ONE, 2011 Gene therapy for sickle cell disease will require efficient delivery of a tightly regulated and stably expressed gene product to provide an effective therapy. In this study we utilized the non-viral Sleeping Beauty (SB) transposon system using the SB100X
Lucas M Sjeklocha +8 more
doaj +1 more source
A structural interpretation of the acidity of groups associated with the hemes of hemoglobin and hemoglobin derivatives [PDF]
, 1940 Since the discovery by Bohr and coworkers in 1904 of the effect of acidity on the oxygen equilibrium of hemoglobin, there have been a large number of investigations directed towards clarification of the physicochemical relationships of acid groups with ...
Coryell, Charles D., Pauling, Linus
core
Prenatal Diagnosis, EarlyView.ABSTRACT Aim In this article, we present two cases of severe fetal hemolytic anemia based on a beta‐thalassaemia trait inherited from a single parent. Results These cases, presented at 20 and 28 weeks' gestation, necessitated intra‐uterine blood transfusions.
Eva van der Meij +11 more
wiley +1 more source
CRISPR-Cas9 interrogation of a putative fetal globin repressor in human erythroid cells.
PLoS ONE, 2019 Sickle Cell Disease and ß-thalassemia, which are caused by defective or deficient adult ß-globin (HBB) respectively, are the most common serious genetic blood diseases in the world. Persistent expression of the fetal ß-like globin, also known as 𝛾-globin,
Jennifer E Chung +11 more
doaj +1 more source
Ligand-dependent reactivity of the CysB5[23] b sulfhydryl group of the major haemoglobin of chicken [PDF]
, 1997 Chicken haemoglobin contains eight reactive sulfhydryl groups per (tetramer) molecule, as determined by Boyer titration with p-chloromercury(II)benzoic acid. However, only four of these sulfhydryls are reactive towards 5,5@-dithiobis(2-nitrobenzoic acid)
Nwozo, Sarah, Okonjo, K. O.
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Conformational studies of various hemoglobins by natural-abundance 13C NMR spectroscopy [PDF]
, 1972 Studies of variously liganded hemoglobins (both from human and rabbit) by natural-abundance 13C NMR spectroscopy have revealed apparent conformational differences that have been interpreted on the basis of two quaternary structures for the α2ß2 tetramer,
Moon, R. B., Richards, J. H.
core +1 more source
Prenatal Diagnosis, EarlyView.ABSTRACT Prenatal exome sequencing (ES) can establish rare genetic diagnoses in a fetus but may also lead to occult genetic diagnosis in a biological parent. We present a case of dual fetal and maternal diagnosis by prenatal ES, in a fetus with unexplained anemia and in a pregnant patient with sickle cell disease (SCD) and recurrent unexplained hypoxia.
Matthew A. Shear +6 more
wiley +1 more source
Decrease of alpha-chains in beta-thalassemia
Thalassemia Reports, 2013 In the pathophysiology of beta-thalassemia, globin chain imbalance plays a central role in predicting red blood cell (RBC) life span and disease severity. Strategies to improve globin chain imbalance are therefore a legitimate target in the management of
M. Papadaki, George Vassilopoulos
doaj +1 more source
Globin Gene Switching in Transgenic Mice Carrying HS2-Globin Gene Constructs [PDF]
Blood, 1997 Abstract We have examined the pattern of human globin gene switching in transgenic mice containing three different γ and β gene constructs (HS2GγAγδβ, HS2Aγβneo, and HS2Aγenβ) and compared the results with previously described transgenics (HS2Aγβ, HS2GγAγ-117δβ, and LCRεGγAγδβ).
N A, Roberts +4 more
openaire +2 more sources