Results 61 to 70 of about 82,601 (269)
Soluble and insoluble globin analyses.
, 2013 (A) Western blot analyses of globin chains were performed using total soluble cytosolic protein (20 µg/lane) from day 14, 18, and 21 cultured erythroblasts. Antibodies against alpha-globin, beta-globin, and gamma-globin were used for comparison.
Jaira F. de Vasconcellos (431552) +7 more
core +1 more source
Controlling α-globin: a review of α-globin expression and its impact on β-thalassemia
Haematologica, 2008 Synthesis of α-globin and α-globin subunits of hemoglobin occurs at high levels during erythrocyte differentiation in a tightly controlled and coordinated fashion.
Hsiao Phin Joanna Voon, Jim Vadolas
doaj +1 more source
Regulation of Gγ-globin gene by ATF2 and its associated proteins through the cAMP-response element. [PDF]
PLoS ONE, 2013 The upstream Gγ-globin cAMP-response element (G-CRE) plays an important role in regulating Gγ-globin expression through binding of ATF2 and its DNA-binding partners defined in this study.
Li Liu +6 more
doaj +1 more source
Discovery of CRBN‐based molecular glue degraders targeting WIZ transcription factor
Bulletin of the Korean Chemical Society, EarlyView.This work reports the discovery of 9l, a novel cereblon‐based molecular glue degrader which targets the WIZ transcription factor. Compound 9l facilitates WIZ‐CRBN ternary complex formation to degrade WIZ, subsequently inducing γ‐globin expression in HUDEP‐2 cells and highlighting its potential as a sickle cell disease therapy.
Tae‐Jun Kim +8 more
wiley +1 more source
The Globin Gene Family in Arthropods: Evolution and Functional Diversity
Frontiers in Genetics, 2020 Globins are small heme-proteins that reversibly bind oxygen. Their most prominent roles in vertebrates are the transport and storage of O2 for oxidative energy metabolism, but recent research has suggested alternative, non-respiratory globin functions ...
Andreas Prothmann +8 more
doaj +1 more source
Status and future of recombinant adeno‐associated virus vector manufacturing
Biotechnology Progress, EarlyView.Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley +1 more source
Ectopic MYBL2-Mediated Regulation of Androglobin Gene Expression
CellsAndroglobin (ADGB) is a highly conserved and recently identified member of the globin superfamily. Although previous studies revealed a link to ciliogenesis and an involvement in murine spermatogenesis, its physiological function remains mostly unknown ...
Antonia Herwig +6 more
doaj +1 more source
Phylogenetic analysis reveals wide distribution of globin X
Biology Direct, 2011 The vertebrate globin gene repertoire consists of seven members that differ in terms of structure, function and phyletic distribution. While hemoglobin, myoglobin, cytoglobin, and neuroglobin are present in almost all gnathostomes examined so far, other ...
Makałowski Wojciech, Dröge Jasmin
doaj +1 more source
Equine Veterinary Journal, EarlyView.Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska +4 more
wiley +1 more source
Decrease of alpha-chains in beta-thalassemia
Thalassemia Reports, 2013 In the pathophysiology of beta-thalassemia, globin chain imbalance plays a central role in predicting red blood cell (RBC) life span and disease severity. Strategies to improve globin chain imbalance are therefore a legitimate target in the management of
M. Papadaki, George Vassilopoulos
doaj +1 more source