Results 91 to 100 of about 94,653 (246)

Cardiovascular Plasticity and Adaptation of High‐Altitude Birds and Mammals

Integrative Zoology, EarlyView.
This schematic depicts the cardiovascular adaptations of mammals and birds to high‐altitude hypoxia. It highlights key phenotypic changes in oxygen transport and cardiac responses, driven by molecular mechanisms including transcriptional regulation and genetic modifications.
Huishang She, Yanhua Qu
wiley   +1 more source

Sparus aurata alpha-1 globin gene, complete cds

, 2006
Identification of Sparus aurata alpha-1 globin gene, including intron sequences and 5'- 3' UTR ...
MATTINA W, D'ASCOLA, ANGELA, CALATRONI, Alberto, BURRASCANO, Emanuele, NASTASI G, CAMPO, Salvatore Giuseppe, CAMPO, Giuseppe Maurizio, FERLAZZO, Alida, AVENOSO, Angela   +8 more
core  

Beta-globin sequence data

, 2015
DNA sequences of the Beta-globin ...
Erik Wapstra (314066), Cliff, Hannah B., Christopher P. Burridge (837365), Hannah B. Cliff (3256020), Wapstra, Erik, Burridge, Christopher P.   +5 more
core   +1 more source

Effect of Testosterone Treatment on Leucocyte Telomere Length in Men: Results From a Randomised Placebo‐Controlled Trial

Andrology, EarlyView.
ABSTRACT Background Lower testosterone concentrations in older men are associated with poorer health outcomes. Objective We examined whether, on a background of lifestyle intervention, testosterone treatment modulates leucocyte telomere length, a postulated marker of biological ageing, in overweight men with impaired glucose tolerance (IGT) or newly ...
Bu B. Yeap, Jennie Hui, Kristy P. Robledo, Gillian Arscott, Mathis Grossmann, David J. Handelsman, Warrick J. Inder, Bronwyn G. A. Stuckey, Alicia J. Jenkins, Karen Bracken, John P. Beilby, Gary A. Wittert   +11 more
wiley   +1 more source

Sparus aurata alpha-2 globin gene, complete cds.

, 2006
Characterization of Sparus aurata alpha-2 globin gene, including intron sequences and 5'- 3' UTR ...
D'ASCOLA, ANGELA, CALATRONI, Alberto, BURRASCANO, Emanuele, NASTASI G, CAMPO, Salvatore Giuseppe, CAMPO, Giuseppe Maurizio, FERLAZZO, Alida, AVENOSO, Angela   +7 more
core  

Platypus globin genes and flanking loci suggest a new insertional model for beta-globin evolution in birds and mammals-5

, 2011
D the β-globin cluster on chromosome 2q5.1 (red). The chromosomes are counterstained with DAPI (blue).Copyright information:Taken from "Platypus globin genes and flanking loci suggest a new insertional model for beta-globin evolution in birds and mammals"
Bob Fulton (70323), Steven JB Cooper (70322), Jennifer AM Graves (42249), Wesley C Warren (70325), Vidushi S Patel (70321), Richard K Wilson (2216), Janine E Deakin (14403), Tina Graves (70324)   +7 more
core   +1 more source

Coordinated β-globin expression and α2-globin reduction in a multiplex lentiviral gene therapy vector for β-thalassemia

, 2021
A primary challenge in lentiviral gene therapy of β-hemoglobinopathies is to maintain low vector copy numbers to avoid genotoxicity while being reliably therapeutic for all genotypes.
Tee, Hsin Y., Voon, Hsiao P.J., Gouzil, Julie, Vadolas, Jim, Payen, E, Leboulch, Philippe, Fucharoen, S, Glaser, A, Leboulch, P, McColl, Bradley, Svasti, Saovaros, Nualkaew, Tiwaporn, Sii-Felice, Karine, Grigoriadis, G, Hongeng, S, Fucharoen, Suthat, Tee, HY, Giorgi, Marie, Voon, HPJ, Svasti, S, McColl, B, Vadolas, J, Nualkaew, T, Sii-Felice, K, Hongeng, Suradej, Gouzil, J, Glaser, Astrid, Payen, Emmanuel, Giorgi, M, Grigoriadis, George, Bradley McColl, Jim Vadolas, Emmanuel Payen, Astrid Glaser, Saovaros Svasti, Tiwaporn Nualkaew, Suradej Hongeng, Karine Sii-Felice, Hsiao P.J. Voon, Marie Giorgi, Julie Gouzil, Suthat Fucharoen, Philippe Leboulch, George Grigoriadis, Hsin Y. Tee   +44 more
core   +1 more source

Phase 3, randomised, placebo‐controlled trial of voxelotor for the resolution of leg ulcers in sickle cell disease: RESOLVE

British Journal of Haematology, EarlyView.
In this trial, conducted in Kenya, Nigeria and Brazil, the resolution of leg ulcers was similar between the voxelotor and placebo arms. In the 12‐week blinded period, the number of sickle cell anaemia with crisis events was higher in the voxelotor arm compared to placebo.
Bernhards Ogutu, Janet Oyieko, Halima Bello‐Manga, Adeseye Akinsete, Jessie Githanga, José Valber Lima Meneses, Carolyn Hoppe, Mark W. Davis, Jeremy Rupon, Ching‐Ray Yu, Roberto Pinto, Elena Tudone, Ibrahim Musa Idris, Martin Meremikwu, Aderson da Silva Araújo, Rodolfo D. Cançado, Guilherme Fonseca, Patrícia Santos Resende Cardoso, Obiageli Eunice Nnodu, on behalf of the RESOLVE Investigators   +19 more
wiley   +1 more source

Inhibition of platelet aggregation by rat globin

, 2002
This study was undertaken to identify and characterize the anti-aggregatory protein factor present in rat polymorphonuclear leukocytes (PMNs) supernatant.
Dikshit, Madhu, Sinha, Sudhir, Singh, Mahendra P., Raghavan, Santhanam A. V.   +3 more
core   +1 more source

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source