Results 111 to 120 of about 94,653 (246)
PLoS ONE, 2012 This study was performed to investigate the hypothesis that the erythroid micro-environment plays a role in regulation of globin gene expression during adult erythroid differentiation.
Donald Lavelle +7 more
doaj +1 more source
An orphaned mammalian b-globin gene of ancient evolutionary origin
, 2001 © 2001 National Academy of SciencesMammals possess multiple, closely linked β-globin genes that differ in the timing of their expression during development.
Bottema, C. +8 more
core +1 more source
Adaptation to extreme environments: A review of Antarctic fish physiology
Journal of Fish Biology, EarlyView.Abstract Having evolved in the chronically cold and thermally stable waters of the Southern Ocean (SO) for millions of years, Antarctic fish possess a suite of physiological specializations that enable them to survive at temperatures near the freezing point of seawater. Adaptations include the evolution of antifreeze proteins, modifications of membrane
Seungyeon Lee +8 more
wiley +1 more source
Human β-like globin expression in adult −566 Aγ-globin HPFH β-YAC transgenic mice.
, 2013 (A and B) Expression of the fetal γ- and adult β-globin was analyzed by real-time qRT-PCR and the data was normalized to mouse α-globin or Gapdh gene expression. (A) Human fetal γ-globin mRNA expression; B) Adult β-globin mRNA expression.
Renee Y. Neades (292761) +4 more
core +1 more source
Experimental Physiology, EarlyView.Abstract Sarcopenia and frailty are complex geriatric syndromes influenced by a combination of genetic and environmental factors. Recent studies suggest that specific genetic variants, DNA methylation patterns and shortened telomeres are associated with age‐related diseases and might contribute to the development of both sarcopenia and frailty. In this
Valentina Ginevičienė +10 more
wiley +1 more source
The effects of a globin blocker on the resolution of 3’mRNA sequencing data in porcine blood
BMC Genomics, 2019 Background Gene expression profiling in blood is a potential source of biomarkers to evaluate or predict phenotypic differences between pigs but is expensive and inefficient because of the high abundance of globin mRNA in porcine blood. These limitations
Kyu-Sang Lim +10 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Metabolic stimulation improves bioenergetics, redox state, hydration and hematologic indices of circulating erythrocytes from sickle cell mice. Retained mitochondria in circulating RBCs from sickle mice are a source of RBC ATP as mitochondria function (ETC, electron transport chain) inhibitors [rotenone, a mitochondrial complex I
Luis E. F. Almeida +4 more
wiley +1 more source
A silent deletion in the beta-globin gene cluster.
, 1986 A survey of the gamma-globin gene region of over 1000 normal individuals revealed a novel 2.5 kb deletion which removes the 5' end of the A gamma-globin gene. Unusually, this deletion in the beta-globin gene cluster is not associated with increased fetal
Tate, VE +5 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend The influence of haemoglobin–O2 affinity on aerobic capacity in hypoxia has been contentious. Many high‐altitude natives have greater haemoglobin–O2 affinity (lower P50, the O2 pressure at 50% haemoglobin saturation) than their low‐altitude counterparts, but the advantages of this change for aerobic metabolism have often remained
Kayla M. Garvey, Graham R. Scott
wiley +1 more source