Results 121 to 130 of about 82,601 (269)

HPV125‐induced generalized verrucosis

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Sven Niklas Burmann, Ulrike Wieland, Finja Schweitzer, Frank Oellig, Mihael Skerlev, David Chromy, Alexander Kreuter, Steffi Silling   +7 more
wiley   +1 more source

Natural History of Chronic Kidney Disease in Sickle Cell Disease

American Journal of Hematology, Volume 101, Issue 7, Page 1456-1477, July 2026.
ABSTRACT Kidney complications, referred to as nephropathy, develop early in sickle cell disease (SCD). In addition to its known morbidity, abundant data show that chronic kidney disease (CKD) is associated with an increased mortality risk in SCD. Increasing evidence suggests that the natural history of SCD nephropathy is progressive. Initial glomerular
Kenneth I. Ataga
wiley   +1 more source

PNAs targeting BCL11A at the miR-210 binding sites down-regulate BCL11A and up-regulate gamma-globin mRNA

, 2016
In β-thalassemia reactivation of γ-globin genes and production of fetal hemoglobin (HbF) is clinically relevant for compensating for the loss of β-globin chain.
Saviano, Michele, SALVATORI, Francesca, LAMPRONTI, Ilaria, GAMBARI, Roberto, GASPARELLO, Jessica, ZUCCATO, Cristina, COSENZA, Lucia Carmela, Avitabile, Concetta, FINOTTI, Alessia, BREVEGLIERI, Giulia, Romanelli, Alessandra, FABBRI, Enrica, BIANCHI, Nicoletta, BORGATTI, Monica, MONTAGNER, Giulia   +14 more
core  

MYB represses ζ-globin expression through upregulating ETO2

Acta Biochimica et Biophysica Sinica
Reactivating the embryonic ζ-globin gene represents a potential therapeutic approach to ameliorate the severe clinical phenotype of α-thalassemia and sickle cell disease.
Dong Zejun, Ye Yuhua, Zhang Wei, Luo Hualei, Li Jialong, Zhang Qianqian, Zhang Xinhua, Guo Xiang, Xu Xiangmin   +8 more
doaj   +1 more source

γ-Globin Reactivation [PDF]

, 2010
β-thalassemia and sickle cell disease are major human genetic health problem in many parts of the world. Available treatments are not satisfactory as none of them exhibit the optimal combination of safety, efficiency and convenience of use that would ...
Pourfarzad, F. (Farzin)
core  

A Novel Plasma Heme Assay Reveals Disease Severity in Beta‐Thalassemia and Sickle Cell Anemia

American Journal of Hematology, Volume 101, Issue 7, Page 1706-1716, July 2026.
ABSTRACT Anemia results from imbalanced hemoglobin or red blood cell production and clearance. Hemolytic anemia, caused by premature red blood cell removal, can be intravascular (in blood) or extravascular (erythrophagocytosis). Hemolysis is common in Sickle Cell Disease (SCD) and Beta‐Thalassemia anemia (β‐thalassemia), the most prevalent inherited ...
Laurent Kiger, Nicolas Hebert, Laura Bencheikh, Vincent Malcor Deydier de Pierrefeu, Anne‐Laure Pham Hung d’Alexandry d’Orengiani, Sandia Adypagavane, Meghan Perkins, Laura Matabishi‐Bibi, France Pirenne, Claire Berquet, Stephane Moutereau, Serge Pissard, Frédéric Galactéros, Michael C. Marden, Pablo Bartolucci   +14 more
wiley   +1 more source

Combined Long‐Read Genome and Transcriptome Sequencing Establishes Novel Variants in MEGF8 as the Cause for Carpenter Syndrome Type 2

American Journal of Medical Genetics Part A, Volume 200, Issue 7, Page 1719-1724, July 2026.
ABSTRACT Carpenter syndrome type 2 (CRPT2) is a rare autosomal recessive disease mainly characterized by craniosynostosis and polysyndactyly. CRPT2 is the rarer subtype of Carpenter syndrome (CRPTS) and is caused by biallelic variants in the multiple epidermal growth factor‐like domains 8 gene (MEGF8).
Kiana Rashidi, Bhavi P. Modi, Phillip A. Richmond, Massimo Mangino, Loryn Byres, Cassie McDonald, Joshua Dalmann, Simran Samra, Kate L. Del Bel, Anna Lehman, Jessica L. Zambonin, Stuart E. Turvey   +11 more
wiley   +1 more source

Structure and expression of the human globin genes and murine histocompatibility antigen genes [PDF]

, 1983
Grosveld, F., Flavell, R.A. (Richard), Weiss, E.H. (Elisabeth), Boer, E. de, Golden, L., Ferluga, J., Schmidt, W., Taylor, P. M., Townsend, A.R.M., Festenstein, H., Busslinger, M., James, R., Mellor, A.L., Flavell, Richard A., Mellor, Andrew L., Atfield, G., Kioussis, D., Leben, L., Boer, E. (Ernie) de, Townsend, A. R., Simpson, E., Bullman, H., Santamaria, M., Schmidt, Walter, Taylor, P.M., Bud, H., Weiss, Elisabeth H., Hurst, J., Grosveld, F.G. (Frank)   +28 more
core   +1 more source

CRISPR/Cas9-mediated γ-globin expression upregulation in HEK293T cells

Guangxi Yike Daxue xuebao
Objective To edit the γ-globin promoter of HEK293T cells using the CRISPR/Cas9 technology to upregulate γ-globin and explore the feasibility of using gene editing technology for the treatment of β-thalassemia.
HUANG Xianjuan, LAI Yongrong, LI Jing
doaj   +1 more source

Population Pharmacokinetics and Pharmacodynamics of Paracetamol in Malaysian Patients With Plasmodium knowlesi Malaria

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 7, July 2026.
ABSTRACT Paracetamol may improve renal function in patients with severe Plasmodium knowlesi malaria, particularly in those with acute kidney injury and hemolysis, via inhibition of cell‐free hemoglobin mediated oxidative kidney damage. We developed a population pharmacokinetic/pharmacodynamic (PK/PD) model to assess effects of paracetamol on creatinine,
Thanaporn Wattanakul, Daniel J. Cooper, Katherine Plewes, Matthew J. Grigg, Giri S. Rajahram, Timothy William, Arjen M. Dondorp, Michael D. Edstein, Geoffrey W. Birrell, Nicholas M. Anstey, Richard M. Hoglund, Bridget E. Barber, Joel Tarning   +12 more
wiley   +1 more source