Results 121 to 130 of about 136,712 (243)
PLoS ONE, 2012 This study was performed to investigate the hypothesis that the erythroid micro-environment plays a role in regulation of globin gene expression during adult erythroid differentiation.
Donald Lavelle +7 more
doaj +1 more source
Pediatric Blood &Cancer, Volume 73, Issue 5, May 2026.ABSTRACT Hemoglobinopathies are prevalent globally; diagnosis is complex in high genetic admixture populations like Brazil. We report, in two pediatric siblings, the first documented cases in Brazil of heterozygosity for hemoglobin (Hb) O‐Arab with coinheritance of α‐thalassemia (αα/−α4.2; −α3.7/−α4.2), resulting in microcytic and hypochromic anemia ...
Elisângela de Souza Miranda Muynarsk +9 more
wiley +1 more source
Haematologica, 2014 A major barrier to the clinical use of erythrocytes generated in vitro from pluripotent stem cells or cord blood progenitors is failure of these erythrocytes to express adult hemoglobin.
Kongtana Trakarnsanga +9 more
doaj +1 more source
HSCB, a co-chaperone in mitochondrial iron-sulfur cluster biogenesis, is a novel candidate gene for congenital sideroblastic anemia [PDF]
, 2017 Congenital sideroblastic anemias (CSA) are inherited diseases resulting from defects in heme biosynthesis, mitochondrial iron-sulfur cluster (ISC) assembly, or mitochondrial translation.
Crispin, Andrew
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Genetic Contribution to Asthma Informs Acute Chest Syndrome Pathophysiology and Risk Stratification
American Journal of Hematology, Volume 101, Issue 5, Page 961-971, May 2026.ABSTRACT Acute chest syndrome (ACS) is a severe complication of sickle cell disease (SCD) occurring in ~50% of patients, some presenting frequent episodes. We lack tools to identify patients at high risk of ACS occurrence or frequent episodes. Epidemiological studies have found an association between asthma and ACS, but whether this link is causal is ...
Sara El Aouhel +10 more
wiley +1 more source
Integrating HDAd5/35++ Vectors as a New Platform for HSC Gene Therapy of Hemoglobinopathies
Molecular Therapy: Methods & Clinical Development, 2018 We generated an integrating, CD46-targeted, helper-dependent adenovirus HDAd5/35++ vector system for hematopoietic stem cell (HSC) gene therapy. The ∼12-kb transgene cassette included a β-globin locus control region (LCR)/promoter driven human γ-globin ...
Chang Li +9 more
doaj +1 more source
Clinical Case Reports, Volume 14, Issue 5, May 2026.Acute infarcts and microvascular ischemic changes in the brain of a young patient with Sickle‐Cell Disease despite High Fetal Hemoglobin. ABSTRACT Sickle‐cell disease (SCD) is characterized by abnormal hemoglobin (Hb) polymerization, leading to erythrocyte sickling and microvascular obstruction.
Yi Hui Luo +5 more
wiley +1 more source
Maternal haemoglobin concentrations before and during pregnancy and stillbirth risk: A population-based case-control study [PDF]
, 2016 Background: Results of previous studies on the association between maternal haemoglobin concentration during pregnancy and stillbirth risk are inconclusive. It is not clear if haemoglobin concentration before pregnancy has a role.
Aarabi, M. +6 more
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PROTEOMICS, Volume 26, Issue 5, Page 112-119, May 2026.ABSTRACT Fragilariopsis cylindrus is a key diatom in the Southern Ocean, where low iron and manganese availability constrain primary production and biogeochemical activity. The molecular mechanisms used by polar diatoms, including F. cylindrus, to cope with trace metal limitations remain largely unexplored.
Loay J. Jabre +3 more
wiley +1 more source
BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 6, Page 1262-1270, May 2026.ABSTRACT Objective To evaluate the analytical suitability of different storage and laboratory processes of self‐samples for an HPV assay. Design Prospective matched study. Setting Royal London Hospital Colposcopy Clinic. Population One hundred seventy seven patients aged 25–65 years referred to colposcopy due to their screening results (abnormal ...
Kim Chu +12 more
wiley +1 more source