Results 141 to 150 of about 94,653 (246)

Interplay between α‐thalassemia and β‐hemoglobinopathies: Translating genotype–phenotype relationships into therapies

HemaSphere
α‐Thalassemia represents one of the most important genetic modulators of β‐hemoglobinopathies. During this last decade, the ongoing interest in characterizing genotype–phenotype relationships has yielded incredible insights into α‐globin gene regulation ...
Jim Vadolas, Tiwaporn Nualkaew, Hsiao P. J. Voon, Shahla Vilcassim, George Grigoriadis   +4 more
doaj   +1 more source

The osmotic pressure of globin [PDF]

Biochemical Journal, 1932
J, Roche, A, Roche, G S, Adair, M E, Adair   +3 more
openaire   +2 more sources

Prediction of Physicochemical Properties, Antioxidant Activity, and Transmembrane Helices of Alpha and Beta Globin Chains of Hemoglobin [PDF]

Research in Molecular Medicine
Background: This study aimed to predict the physicochemical properties, antioxidant activity, and potential penetration of alpha helices of the alpha- and beta-globin chains of human hemoglobin in membranes of red blood cells (RBCs).
Roohallah Yousefi, Seyed Hossein khaleghinejad, Dariush Gholami, Sadegh Hasannia   +3 more
doaj  

Reactivation of the embryonic ζ-globin gene ameliorates severe forms of α-thalassemia. [PDF]

Nat Genet
Liu S, Ejaz A, King AJ, Olijnik AA, Sloane-Stanley J, Scott C, Amid A, Biggs D, Davies B, Eglinton J, Martyn G, Crossley M, Babbs C, Kassouf MT, Higgs DR.   +14 more
europepmc   +1 more source

Clinical analysis of abnormal hemoglobin detection results in northern Guangxi, China. [PDF]

Mol Genet Metab Rep
Yang W, Wu X, Xie Q, Kang Q.
europepmc   +1 more source

Structure and organization of Caprinae globin genes

, 2002
In order to obtain molecular and biochemical data, which might help to elucidate aspects of evolution of Caprinae globin genes, we characterized the Hb phenotype of Ammotragus lervia (Barbary sheep) and compared it with O.
El-Sherbini, El Said, Serreri, Eva, Palici di Suni, Marcella, Hadjisterkotis, Eleftherios, Manca, Laura, Pirastru, Monica, Masala, Bruno Lucio   +6 more
core  

Precision base-editing of the cryptic 3' acceptor site to correct the RNA splicing defect of β⁶⁵⁴-thalassemia. [PDF]

Mol Biomed
Lu D, Gong X, Guo X, Cai Q, Li W, Chen Y, Li D, Zeng F.   +7 more
europepmc   +1 more source

Calcium-dependent proteolysis of the chimeric androglobin reveals altered localization of its isolated globin domain. [PDF]

J Biol Chem
Koay TW, Osterhof C, Clerc A, Hoogewijs D.   +3 more
europepmc   +1 more source

Regulation of the Human Alpha-Globin Genes by GKLF

, 2008
EKLF and related Krueppel-like factors (KLFs) are variably implicated in the regulation of the ?- and ?-like globin genes. Prompted by the observation that four KLF sites are distributed in the human -globin promoter, we investigated if any of the ...
Maria Giuseppina Loi, Lisa Anna Cabriolu, Isadora Asunis, Paolo Moi, MD, Antonio Cao, Giuseppina Maria Marini, Loredana Porcu, PhD   +8 more
core  

Modifying quality and equity of care: emerging roles of genetic disease modifiers in β-hemoglobinopathies. [PDF]

Blood Adv
Papasavva PL, Dosunmu-Ogunbi AM, Morohuntodun OO, Kountouris P, Makani J, Zilfalil BA, Inusa BPD, Archer NM, Lederer CW, International Hemoglobinopathy Research Network.   +9 more
europepmc   +1 more source