Results 141 to 150 of about 82,601 (269)

Spatial transcriptomics reveals a new cluster of fibroblasts to promote the progression of lung adenocarcinoma

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
1. Spatial transcriptomics reveals two types of colocation patterns between lung cancer cells and fibroblasts in LUAD. SPP1+ TM4SF4+ epithelial cells and COL+ fibroblasts were co‐located in a highly malignant region, while SFTPC+ epithelial cells and DCN+ fibroblasts were in a low malignant region. 2.
Liyang Li, Xiaoxia Liu, Yifei Liu, Xuanqi Liu, Wanxin Duan, Yujia Jiang, Jian Chen, Tianxiang Chen, Gang Chen, Ao Chen, Duojiao Wu, Dongli Song, Yuanlin Song   +12 more
wiley   +1 more source

ß-globin gene regulation and chromatin structure [PDF]

, 1999
Oxygen transport in the blood is mediated by highly specialized red cells. The majority of the proteins of a red cell comprises the oxygen carrier protein hemoglobin, which is a hetero-tctrameric protein that consists of two a and two p globin chains. In
Gribnau, J.H. (Joost)
core   +1 more source

Electrophoretic studies of blood globin preparations

, 1985
Isoelectric focusing (IEF) across an urea gradient, and titration curves obtained by IEF—electrophoresis with and without urea, were used to characterize porcine and bovine haemoglobin and globins prepared either by the cold-acetone method (native globin)
Autio, Karin, Kanko, Sirpa, K. Autio, S. Kanko   +3 more
core   +1 more source

Interplay between α‐thalassemia and β‐hemoglobinopathies: Translating genotype–phenotype relationships into therapies

HemaSphere
α‐Thalassemia represents one of the most important genetic modulators of β‐hemoglobinopathies. During this last decade, the ongoing interest in characterizing genotype–phenotype relationships has yielded incredible insights into α‐globin gene regulation ...
Jim Vadolas, Tiwaporn Nualkaew, Hsiao P. J. Voon, Shahla Vilcassim, George Grigoriadis   +4 more
doaj   +1 more source

Compound Heterozygosity for Hemoglobin S and Hemoglobin LuLu Island

American Journal of Hematology, Volume 101, Issue 7, Page 1440-1442, July 2026.
Dana Lewis, Thomas Lofaro, Laura Fraser, Sheana Wijemanne, Barbara J. Bain   +4 more
wiley   +1 more source

Multiplexed Retinoic Acid Signal Reporters for In Vivo and In Vitro Use

genesis, Volume 64, Issue 3, June 2026.
ABSTRACT Here we describe the optimisation of a modular, generally applicable and rapid method to make multimerised signaling‐molecule reporters for detecting different retinoic acid concentrations. The technical plasmid design allows for the easy exchange of reporters, promoters, signal‐responsive elements as well as for the multimerization of entire ...
Craig Smith, Bianca Black, Ric Broadhurst, Stacey Parbhu, Peter L. Pfeffer   +4 more
wiley   +1 more source

EHA Recommendations for preconceptual and antenatal screening and prenatal diagnosis for hemoglobinopathies

HemaSphere, Volume 10, Issue 6, June 2026.
Abstract Thalassemia and sickle cell disease (SCD) are among the most common monogenic disorders worldwide. They cause chronic hemolytic anemia, the consequences and prognosis of which vary considerably depending on the genetic characteristics of patients and the healthcare system in their country of residence.
Mariane de Montalembert, Maria D. Cappellini, Achille Iolascon, Lucia de Franceschi, Eda Ömur, Michele Abi Saad, Immacolata Andolfo, Celeste Bento, Maria Berghs, Doris Bonnet, Andreas Glenthoj, Beatrice Gulbis, Tuphan K. Dolai, Jorge Lima, Irene Motta, Roberta Russo, Ali Taher, Leon Tshilolo, Antonio Almeida, David Rees   +19 more
wiley   +1 more source

The regulation of ζ-globin expression

, 2019
Expression of the embryonic α-like globin gene, ζ-globin, is limited to the early stages of primitive erythropoiesis. Under normal circumstances it is completely silenced in definitive erythroid cells, despite lying adjacent to a âsuper-enhancerâ ...
Andrew King
core  

The osmotic pressure of globin [PDF]

Biochemical Journal, 1932
J, Roche, A, Roche, G S, Adair, M E, Adair   +3 more
openaire   +2 more sources

Globin zinciri elektroforezinin hemoglobinopatilerin tanısındaki yeri

, 1992
fi-talasemi ve orak hücreli anemi Akdeniz halklarının önemli kalıtsal hematolojik bozukluklarıdır. Bu hematolojik bozuklukların laboratuvar tanısında alfa, beta, gamma ve delta globin zincirlerinin tespiti önemlidir.
Yılmaz, Necat
core