Results 131 to 140 of about 94,653 (246)

The role of iron in normal and impaired testicular function

Andrology, Volume 14, Issue 8, Page 2373-2387, November 2026.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

MYB represses ζ-globin expression through upregulating ETO2

Acta Biochimica et Biophysica Sinica
Reactivating the embryonic ζ-globin gene represents a potential therapeutic approach to ameliorate the severe clinical phenotype of α-thalassemia and sickle cell disease.
Dong Zejun, Ye Yuhua, Zhang Wei, Luo Hualei, Li Jialong, Zhang Qianqian, Zhang Xinhua, Guo Xiang, Xu Xiangmin   +8 more
doaj   +1 more source

KLF1 regulates β-globin, total globin and BCL11A expression in UCB erythroblasts.

, 2016
The amount of KLF1, β-globin, γ-globin and BCL11A mRNA was measured by qRT-PCR and normalized to Cyclophilin A mRNA. The fold change in expression of these genes in KLF1 shRNA-treated samples was calculated by setting the value in Scr shRNA controls to ...
Joyce A. Lloyd (282148), Yousef N. Alhashem (2141143), Safa F. Mohamad (2141146), David C. Williams Jr. (2141152), Divya S. Vinjamur (2141155), Parth Amin (2141149)   +5 more
core   +1 more source

Nuclear Wrinkles Result From Geometric Adaptations to Cellular and Nuclear Morphological Changes in Epithelial Cells

Genes to Cells, Volume 31, Issue 6, November 2026.
Changes in cell geometry caused by increased cell density, F‐actin disruption, or trypsinization promote nuclear rounding and nuclear wrinkle (NW) formation. NWs arise through passive redistribution of excess nuclear surface area and are reversible, without detectable DNA damage, stress‐associated histone H3 Ser10 phosphorylation, or global nuclear ...
Le Minh Khoa, Yohei Kono, Takeshi Shimi, Hiroshi Kimura   +3 more
wiley   +1 more source

Roles of fetal G gamma-globin promoter elements and the adult beta-globin 3' enhancer in the stage-specific expression of globin genes

, 1990
The human fetal G gamma-globin and adult beta-globin genes are expressed in a tissue- and developmental stage-specific pattern in transgenic mice: the G gamma gene in embryonic cells and the beta gene in fetal and adult erythroid cells.
Costantini, F, Perez-Stable, C
core   +1 more source

The Maternal Blood Transcriptome Reflects Molecular Signatures Associated With Large Offspring Syndrome and Other Adverse Pregnancy Outcomes in Cattle

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
Blood samples from pregnant heifers carrying in vitro‐produced embryos were analyzed for RNA‐sequencing to test whether maternal blood transcriptome could be predictive of large offspring syndrome, stillbirth, and abortion compared with controls.
Tatiane S. Maia, Maria B. Rabaglino, Rebecca Krisher, Paula Rodriguez‐Villamil, Jeniffer Pamela J. Laguna, Jeniffer F. Escoto, Yanping Zhang, Abigail J. Sproull, Peter J. Hansen   +8 more
wiley   +1 more source

A Cytosine‑Bulged (3+1) Hybrid G‑Quadruplex Formed by the Chicken DNA Replication Origin

Chemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.
The first high‐resolution structure of an OGRE‐derived G‐quadruplex from the chicken β‐globin replication origin reveals an intramolecular three‐layer (3+1) hybrid fold with a cytosine bulge and an unprecedented 5'‐outer‐quartet anti guanine, creating a distinctive surface for molecular recognition.
Yingying You, Monica Ching Suen, Haitao Miao, Yanyan Geng, Rahman Ud Din, Mu Yuan, Qiang Xue, Xiaoting Li, Naining Xu, Zhihong Guo, Hon‐Ming Lam, Kwok‐Wai Lo, Changdong Liu, Guang Zhu   +13 more
wiley   +1 more source

Chromatin Structure and Control of β-Like Globin Gene Switching

, 2002
The human β-globin locus is a complex genetic system widely used for analysis of eukaryotic gene expression. The locus consists of five functional β-like globin genes, ε,Gγ,Aγ, δ, and β, arrayed on the chromosome in the order that they are expressed ...
Susanna Harju, Kellie J. McQueen, Kenneth R. Peterson   +2 more
core   +1 more source

Clinical Validation of Four Point‐of‐Care High‐Risk HPV Assays, Including Two Reduced‐Valency Assays, for Cervical Cancer Screening in Low‐Resource Settings

International Journal of Cancer, Volume 159, Issue 8, Page 2004-2014, 15 October 2026.
High‐risk human papillomavirus (hrHPV) testing improves cervical cancer screening by facilitating earlier detection and prevention. In low‐resource settings, however, cost and increased referrals limit its use. At the same time, many new and more affordable assays lack validation.
Neerja Bhatla, MaryLuz Rol, Seema Singhal, Showket Hussain, Anushree Patil, Pranay Tanwar, Shalini Singh, Vikrant M. Bhor, Kiran Munne, Richa Vashishtha, Shachi Vashist, Eric Lucas, Richard Muwonge, Arianis Tatiana Ramírez, Anju Singh, Vikas Khan, Jyoti Rani, Nasera Firdausi, Sandeep Sisodiya, Rutuja Wakchaure, María Alejandra Picconi, Alejandro Calderón, Margo Bell, Annemie De Smet, Alex Vorsters, Gary M. Clifford, Madhavi Chandra, Jitendra Kumar, Partha Basu   +28 more
wiley   +1 more source

Platypus globin genes and flanking loci suggest a new insertional model for beta-globin evolution in birds and mammals-6

, 2011
Ster in zebrafish () and frog (), and beside the separate α-globin and β-globin clusters in chicken (), opossum () and human (from Ensembl []. The pufferfish () flanking loci shown here were adapted from Gillemans et al. [].
Bob Fulton (70323), Steven JB Cooper (70322), Jennifer AM Graves (42249), Wesley C Warren (70325), Vidushi S Patel (70321), Richard K Wilson (2216), Janine E Deakin (14403), Tina Graves (70324)   +7 more
core   +1 more source