Results 161 to 170 of about 82,601 (269)

Comprehensive Review of Genetic and Epigenetic Regulation of Fetal Hemoglobin in β-Hemoglobinopathies: From Molecular Mechanisms to Clinical Applications. [PDF]

Mediterr J Hematol Infect Dis
Abu Za'ror YSM, Suleiman JB, Delmani FA, Alhmoud JF, Ayasreh AM, Al-Wendawi SI, AlRamadneh TN, Azlan M.   +7 more
europepmc   +1 more source

Ribosomal Proteins in Cell Biology and Cancer

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The functions of ribosomal proteins (RPs) extend beyond the conventional translation process, as they also regulate gene expression, stress responses, and disease progression. Dysregulation of RPs contributes to the onset and progression of various diseases, including cancer and ribosomopathies, underscoring their dual role as critical disease ...
Ao Zhang, Zeguang Sun, Xinyang Song, Xikun Zhou, Jing Li   +4 more
wiley   +1 more source

Evolution - #5: Globin Gene Evolution

, 2019
For this lesson, students are guided through the steps necessary to compare nucleotide and amino acid sequences available at the National Center for Biotechnology Information that is maintained by the National Institutes of Health. The lesson starts with
O\u27Leary-Driscoll, Sarah, Randall, Crystal, Amacher, Jessica, Anjur, Sowmya, Dosch, Donald   +4 more
core  

New Gene Therapy Strategy for β-Thalassemia. [PDF]

Stem Cell Rev Rep
Liang D, Schmidt-Wolf IGH, Pu J.
europepmc   +1 more source

Pitfalls and missing links in current understanding of 4D genomes

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract The spatial and temporal organization of the genome—collectively termed the 4D genome—is pivotal for regulating gene expression, maintaining genome stability, and guiding development. The convergence of chromosome conformation capture technologies, super‐resolution microscopy, and single‐cell epigenomics has transformed our understanding of ...
Michael Q. Zhang
wiley   +1 more source

Clinical phenotypic heterogeneity in pediatric-thalassemia carriers co-inherited with-globin gene triplication. [PDF]

Ann Hematol
Chen L, Zhou Q, Wu S.
europepmc   +1 more source

Red blood cell membrane proteome as a reporter of disease severity, transfusion impact and genetic background in transfusion‐dependent β‐thalassaemia

British Journal of Haematology, Volume 208, Issue 6, Page 1980-1992, June 2026.
Summary Omics technologies have transformed research in haemoglobinopathies, yet the proteome of RBCs remains largely unexplored in transfusion‐dependent thalassaemia (TDT). In this proteomic analysis, Red blood cell (RBC) membranes from 48 adults with TDT were compared with healthy controls.
Konstantina Theocharaki, Sophia Delicou, Aikaterini Ntzoura‐Kani, Nikolaos Simantiris, Marianna Politou, Veroniki Komninaka, Martina Samiotaki, Jerome Zoidakis, Marianna H. Antonelou   +8 more
wiley   +1 more source

Decoding thalassemia and sickle cell disease: advances in molecular technologies for comprehensive variant detection. [PDF]

Front Genet
Foord E, Sairafi D, Berg M, Westerling S, Adigun T, Uzunel M, Papasavva T, Uhlin M.   +7 more
europepmc   +1 more source

A genetic risk score based on BCL11A and HBS1L‐MYB variants predicts clinical severity in Brazilian sickle cell anaemia patients

British Journal of Haematology, Volume 208, Issue 6, Page 2203-2211, June 2026.
Summary Individuals with sickle cell anaemia (SCA) exhibit significant clinical heterogeneity influenced by several factors, especially fetal haemoglobin (HbF) levels. Variations in adult HbF levels are partly explained by the co‐inheritance of genetic variants that regulate globin expression.
Gabriela S. Arcanjo, Alexsandro P. Silva, Madi V. Diniz, Igor F. Domingos, Diego A. Pereira‐Martins, Amanda B. Araújo, Talita S. S. França, Ana C. Anjos, Aderson S. Araujo, Edis Belini‐Junior, Sara T. O. Saad, Fernando F. Costa, Antonio R. Lucena‐Araujo, Marcos André C. Bezerra   +13 more
wiley   +1 more source

Mutation Spectrum of Hemoglobinopathies in Tunisia. [PDF]

Hum Mutat
Moumni I, Khalfaoui K, Chebbi M, Chaouch L, Ouragini H, Chaouechi D, Mellouli F, Ouederni M, Benkhaled M, Abbes S, Menif S.   +10 more
europepmc   +1 more source