Results 161 to 170 of about 136,712 (243)

Molecular Testing in Sickle Cell Disease: From Newborn Screening to Transfusion Care

International Journal of Laboratory Hematology, Volume 48, Issue 2, Page 295-304, April 2026.
ABSTRACT Sickle cell disease (SCD) is one of the most frequent monogenic diseases worldwide and a highly heterogeneous and complex disease. SCD care carries several challenges. This includes early and accurate diagnosis as well as optimal red blood cell transfusion matching in this population carrying a high risk of alloimmunization.
Thomas Pincez, Yves D. Pastore
wiley   +1 more source

The role of hydroxyurea in modulating miRNA expression in sickle cell disease: molecular mechanisms and therapeutic implications. [PDF]

Ann Hematol
Mirzaee F, Khamoushi A, Dolati R, Abbasi A.   +3 more
europepmc   +1 more source

Clinical value of miR-329-3p in thalassemia and its regulation of TNRC6B expression. [PDF]

Ann Hematol
Zhao Y, Gao J, Li Y, Li S, Li W, Cen M.
europepmc   +1 more source

A functional overlap between actively transcribed genes and chromatin insulator elements. [PDF]

EMBO J
Cornell LJ, Harrold CL, Holliman S, Tsang F, Gosden ME, Hanssen LLP, Stolper R, Downes DJ, Biggs D, Preece C, Alghadban S, Sharpe JA, Davies B, Sloane-Stanley JA, Hughes JR, Higgs DR, Kassouf MT.   +16 more
europepmc   +1 more source

Advances in CRISPR Base Editing: From Molecular Evolution to Therapeutic Applications in Genomic Medicine

Journal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.
ABSTRACT CRISPR‐Cas9 systems revolutionized gene editing, but inherent drawbacks, namely DNA double‐strand breaks (DSBs) and the difficulty of achieving precise repairs (due to low HDR efficiency), led researchers to invent new, more accurate gene editing tools.
Melike Aliciaslan, Ezgi Erbasan, Fulya Erendor, Salih Sanlioglu   +3 more
wiley   +1 more source

Protein Arginine Methyltransferases in γ-Globin Regulation and Sickle Cell Disease: Emerging Connections to Oxidative Stress. [PDF]

Antioxidants (Basel)
Chauhan W, Zennadi R.
europepmc   +1 more source

First clinical and molecular characterization of two rare complex β-globin variants in Chinese population using third generation sequencing. [PDF]

Ann Hematol
Zhang L, Zhuang J, Huang N, Fu W, Chen C.   +4 more
europepmc   +1 more source

CCND3 Suppression Ameliorates β-Thalassaemia in a Murine Disease Model: A Potential Therapeutic Strategy. [PDF]

Cells
Caria CA, Marongiu MF, Porcu S, Poddie D, Vaccargiu S, Vadolas J, Meloni A, Perseu L, Olianas A, Ristaldi MS.   +9 more
europepmc   +1 more source

Histone methyltransferase G9a crosstalks with H3K36 histone methyltransferases NSD3 and SETD2 to mediate gene activation. [PDF]

Front Cell Dev Biol
Shah A, Chaturvedi CP, Singh K, Katiyar S, Sharma A.   +4 more
europepmc   +1 more source

A Deep Dive into the Globin Superfamily of Sharks, Skates, and Rays: Contrasting Patterns of Gene Loss and Retention Relative to Bony Vertebrates. [PDF]

Genome Biol Evol
Walt HK, Hinton JA, Kuraku S, Opazo JC, Storz JF, Hoffmann FG.   +5 more
europepmc   +1 more source