Results 101 to 110 of about 82,601 (269)

Engineering Globin Gene Expression

, 2019
Hemoglobinopathies, including sickle cell disease and thalassemia, are among the most common inherited genetic diseases worldwide. Due to the relative ease of isolating and genetically modifying hematopoietic stem and progenitor cells, recent gene ...
Aishwarya Gurumurthy, Mir A. Hossain, Eliot M. Gunn, Rachael Davis, Jörg Bungert   +4 more
core   +1 more source

The structure of a human alpha-globin pseudogene and its relationship to alpha-globin gene duplication.

, 1980
The complete nucleotide sequence of a human alpha-globin pseudogene (psi alpha 1) is presented. Comparison of this sequence with a normal human alpha-globin gene (alpha 2) reveals that psi alpha 1 contains both an initiator codon mutation and frameshift ...
Proudfoot, NJ, Proudfoot, Nicholas, Maniatis, T   +2 more
core   +1 more source

Project Sickle Cure: A Prospective, International Observational Study of Hematopoietic Cell Transplantation for Sickle Cell Disease

European Journal of Haematology, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic and life‐limiting hemoglobin and systemic vascular disease. While over 1000 people have undergone hematopoietic cell transplantation (HCT) over the last 40 years, long‐term disease‐specific and health‐related quality of life data are lacking.
Gregory M. T. Guilcher, Allistair Abraham, Staci D. Arnold, Christine Camacho‐Bydume, Jenny Duong, Scott Gillespie, Ann Haight, Monica L. Hulbert, Naresh Kumar, Katie Liu, Cherry Mammen, Aleksandra Mineyko, Abra Morgan, Alexander Ngwube, Robert S. Nickel, Araby Roberts, Fiona Schulte, Stephen Sands, Akshay Sharma, John T. Horan, Elizabeth O. Stenger   +20 more
wiley   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

Chimera of Globin/Nitric Oxide Synthase: Toward Improving Nitric Oxide Homeostasis and Nitrogen Recycling and Availability

Frontiers in Plant Science, 2020
Fiorella Del Castello, Andrés Nejamkin, Noelia Foresi, Lorenzo Lamattina, Natalia Correa-Aragunde   +4 more
doaj   +1 more source

Arsenite methyltransferase 3 is required for mitochondrial function and hepatic lipid metabolism

The FEBS Journal, EarlyView.
AS3MT is a protein that helps the body process arsenic, a naturally occurring toxin found in water and soil. We discovered it also helps cells make and use energy properly. Without AS3MT, cells' mitochondria do not work well, leading to fatty liver and reduced activity. Increasing AS3MT in liver cells restores energy and protects against arsenic damage,
Patrice Delaney, James Griffin, Nouf Khan, Balnur Ibrash, Matthew J. O'Connor, Tomas Venit, Elizabeth Mayela Ambrosio, Spiros A. Pergantis, Elke Ober, Piergiorgio Percipalle, Kirsten C. Sadler   +10 more
wiley   +1 more source

beta-globin gene cluster haplotype frequencies in Khalkhs and Buryats of Mongolia

, 2006
beta-globin gene cluster haplotype frequencies of 169 Khalkhs and 145 Buryats were estimated, and their characteristics were compared with those of Evenkis, Oroqens, Koreans, Japanese, and three Colombian Amerindian groups.
Takeuchi, Yukiko, Omoto, Keiichi, Tokimasa, Kozue, Hao, Luping, Shimizu, Koji, Gereksaikhan, Tudevdagva, Jing, Feng, Imanishi, Tadashi, Harihara, Shinji, Tanabe, Yuichi   +9 more
core  

Molecular cloning of human epsilon-globin gene.

, 1979
Human beta-like globin genes were investigated by use of rabbit beta-globin cDNA plasmid as a cross-species hybridization probe. Normal and beta 0/delta beta 0 thalassemic DNA were compared by filter hybridization procedures.
Proudfoot, Nicholas, Baralle, FE
core   +1 more source

Effect of AGM and fetal liver-derived stromal cell lines on globin expression in adult baboon (P. anubis) bone marrow-derived erythroid progenitors.

PLoS ONE, 2012
This study was performed to investigate the hypothesis that the erythroid micro-environment plays a role in regulation of globin gene expression during adult erythroid differentiation.
Donald Lavelle, Kestutis Vaitkus, Maria Armila Ruiz, Vinzon Ibanez, Tatiana Kouznetsova, Yogen Saunthararajah, Nadim Mahmud, Joseph DeSimone   +7 more
doaj   +1 more source

A case report of soluble A antigen confounding the blood type in a haplo‐identical hematopoietic stem cell transplant patient with graft‐versus‐host disease

Transfusion, EarlyView.
Abstract Background ABO‐incompatible (ABOi) hematopoietic stem cell transplantation (HSCT) is often associated with ABO discrepancies post‐HSCT. Re‐emergence of the patient's original type post‐HSCT may signal graft loss, disease relapse, recent transfusion, or soluble ABO antigen.
Sheri Hugan, Nada Naiyer, Laura Cooling
wiley   +1 more source