Results 41 to 50 of about 26,664 (228)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Prevalence of metabolic syndrome in beta-thalassemia major adult patients in Tanta University Hospitals [PDF]

, 2022
Introduction: one of long-term complications of Beta-thalassemia major (β-TM) disease is metabolic syndrome, which has a significant influence on patients' quality of life.
Nashwa Mohamed Abu Elnassr, Mabrouk, Maaly Mohamed, Tamer Abd Elhamid Elbedewy, Elbedewy, Tamer Abd Elhamid, Elnassr, Nashwa Mohamed Abu, Eida, Reham Abd Elmageed Abo, Reham Abd Elmageed Abo Eida, Maaly Mohamed Mabrouk   +7 more
core   +2 more sources

Economic burden of beta-thalassemia/Hb E and beta-thalassemia major in Thai children [PDF]

BMC Research Notes, 2010
Hemoglobin E beta-thalassemia (beta-thalassemia/Hb E) has a variable severity, and the cost of treatment has not been well studied. The aim of this study was to analyze the societal cost of caring for children with beta-thalassemias in Thailand. The study was designed as a prevalence-based cost-of-illness analysis in a societal perspective.
Ragil Setia Dianingati, Issarang Nuchprayoon, Kitti Torcharus, K Indaratna, Montarat Thavorncharoensap, Bang-on Ubol   +5 more
openaire   +3 more sources

Synergistic HMGN1 and VP64 Fusions Potentiate High‐Precision and PAM‐Flexible Base Editing

Advanced Science, EarlyView.
A novel CDA1Δ‐SpRY architecture fused with HMGN1 and VP64 yields a nearly PAM‐less base editing platform. By focusing cytosine conversion predominantly at position −18, this synergistic complex ensures highly precise targeting. Demonstrating enhanced efficiency across diverse models, including yeast and rice, the platform offers a robust solution for ...
Xi Luo, Yuyao Qu, Zhengyan Ye, Zheng Li, Yuanyan Zhang, Longjiong Luo, Shaokang Li, Wei Zhao, Ming Wang, Ralph Bock, Jianmin Wan, Junjie Tan   +11 more
wiley   +1 more source

Pharmacotherapy of Beta Thalassemia Major [PDF]

, 2017
The aim of this thesis is to discuss the incidence, aetiology, clinical manifestation, diagnosis and pharmacological management of beta thalassemia major.
Kazemi Mohammadi, Seyedeh Maral
core  

Clinical Course of COVID-19 in a Thalassemia Major Patient who Underwent Haematopoietic Stem Cell Transplantation

Bezmiâlem Science, 2021
We herein reported the course of Coronavirus diasease-19 (COVID-19) in a 21-year-old patient with thalassemia majo rdisease. The patient who underwent haematopoietic stem cell transplantation in 2013 and developed alloimmunization, presented with high ...
Aziz Ahmad HAMİDİ, Yıldız ULU, Habibullah AKTAŞ   +2 more
doaj   +1 more source

Elevated Hemoglobin A2: A Molecular Revisited, and Implications to β‐Thalassemia Screening

Journal of Clinical Laboratory Analysis, EarlyView.
In Thailand, the Hb A2 cut‐off value for β‐thalassemia carrier has been changed from 4.0% to 3.6% since 2015. We examined the molecular basis of β‐thalassemia in a large cohort of Thai subjects with this change. The molecular basis of β‐thalassemia was updated, and a change in the Hb A2 cut‐off can alter this spectrum.
Kritsada Singha, Anupong Pansuwan, Hataichanok Srivorakun, Attawut Chaibunruang, Supawadee Yamsri, Wanicha Tepakhan, Kanokwan Sanchaisuriya, Goonnapa Fucharoen, Supan Fucharoen   +8 more
wiley   +1 more source

Venous thromboembolism risk assessment among beta-thalassemia patients

Journal of Applied Hematology, 2023
BACKGROUND: Thromboembolic (TE) disorders are among the most common complications of beta-thalassemia. We designed this cross-sectional study to investigate the state of hypercoagulability and platelet activation in patients with beta-thalassemia ...
Hasnaa A Abo-Elwafa, Laila M Youseff, Ramadan A Mahmoud, Mahmoud I Elbadry, Ahmed Tawfeek, Shereen P Aziz   +5 more
doaj   +1 more source

Application of Cell‐Free DNA Barcode‐Enabled Single‐Molecule Test for Non‐Invasive Prenatal Testing of α‐Thalassemia and β‐Thalassemia

Journal of Clinical Laboratory Analysis, EarlyView.
We evaluated the cfBEST assay for non‐invasive prenatal testing of α‐ and β‐thalassemia in 72 families. The assay correctly identified 88 of 93 fetal alleles, achieving an overall accuracy of 94.6%, a sensitivity of 94%, and a specificity of 95.35%, with 100% concordance with postnatal follow‐up.
Qin Liu, Na Ma, Wanglan Tang, Qianting Chen, Deguo Tang, Chunyan Zeng, Xiaofeng Wang, Hui Xi   +7 more
wiley   +1 more source

Factors associated with continuing emergence of β-thalassemia major despite prenatal testing: a cross-sectional survey [PDF]

, 2017
Haleama Al Sabbah,1 Sarah Khan,1 Abdallah Hamadna,2 Lamia Abu Ghazaleh,2 Anwar Dudin,2 Bashar Adnan Karmi3 1College of Natural and Health Sciences, Zayed University, Dubai, UAE; 2Faculty of Medicine, An-Najah National University, Nablus, Palestine ...
Al Sabbah H, Hamadna A, Dudin A, Karmi BA, Abu Ghazaleh L, Khan S   +5 more
core