Results 41 to 50 of about 5,832,501 (223)

Cell and Gene Therapies Manufacturing Challenges and Integrated Good Manufacturing Practices Solutions: A Lifecycle Perspective

Biotechnology and Bioengineering, EarlyView.
Lifecycle perspective on cell and gene therapy manufacturing challenges and enabling GMP solutions. ABSTRACT Cell and gene therapies (CGTs) are revolutionizing modern medicine; however, making these advanced medicines scalable and readily available to commercial manufacturers worldwide is a major challenge. The number of approved CGT products continues
Rajath Samaga, Udisha Singh, Sachin Dattram Pawar   +2 more
wiley   +1 more source

Clinical Course of COVID-19 in a Thalassemia Major Patient who Underwent Haematopoietic Stem Cell Transplantation

Bezmiâlem Science, 2021
We herein reported the course of Coronavirus diasease-19 (COVID-19) in a 21-year-old patient with thalassemia majo rdisease. The patient who underwent haematopoietic stem cell transplantation in 2013 and developed alloimmunization, presented with high ...
Aziz Ahmad HAMİDİ, Yıldız ULU, Habibullah AKTAŞ   +2 more
doaj   +1 more source

Polyneuropathy and myopathy in beta-thalassemia major patients

Annals of Hematology, 2018
The thalassemias are the most common single gene disorder in the world. Nowadays, the average life expectancy of patients in developed countries has increased significantly, while, there was an increase of complications. We aimed to investigate peripheral neuropathy and myopathy in this patient group using a neurophysiological study. We performed nerve
P. Nemtsas, M. Arnaoutoglou, V. Perifanis, E. Koutsouraki, G. Spanos, N. Arnaoutoglou, P. Chalkia, D. Pantelidou, A. Orologas   +8 more
openaire   +3 more sources

Application of Machine Learning Approaches in Electrophoresis—A Comprehensive Review

ELECTROPHORESIS, EarlyView.
This review paper highlights key research on the applications of machine learning tools in electrophoresis. ABSTRACT The electrophoretic technique is widely used to analyze and purify charged molecules based on their size, shape, and charge using an electric field for various applications, including DNA fingerprinting, genetic research, disease ...
Umaeer Al Hammad, Aminul Islam Khan, Prashanta Dutta   +2 more
wiley   +1 more source

Phenotypic and Genotypic Analysis of Two Rare Cases of ‐‐SEA/‐α4.3 HbH Disease

Journal of Clinical Laboratory Analysis, EarlyView.
We report two unrelated adult patients with rare deletional HbH disease (genotype ‐‐SEA/‐α4.3). This novel 4.3 kb deletion covering the HBA1 gene is accompanied by X‐Y‐Z segment recombination, which was identified by CycloneSEQ long‐read nanopore sequencing.
Weijia Yang, Xiaoyan Huang, Li Zhang, Xiaoqin Yang, Yaya Guo, Qingping Kang, Min Dou, Guijun Huang   +7 more
wiley   +1 more source

Chronic hyperplastic anemia as an independent risk factor for atherosclerotic lesions: a lesson from thalassemia intermedia [PDF]

, 2010
Introduction. Cardiovascular involvement represents a well-known complication and the primary cause of mortality, both in transfusion-dependent beta thalassemia major (β-TM) and in transfusion-independent beta thalassemia intermedia (β-TI ...
Pier Luigi Cocco, Alessandra Spiga, Fabrizio Angius, Stefania Vacquer, Maria Eliana Lai, Antonella Mandas, Maria Paola Carta, Sandra Dessi   +7 more
core  

Endocrine Complications in Patients with  -thalassemia Major [PDF]

Journal of Tropical Pediatrics, 2002
Thirty-seven patients with thalassemina major (TM) were studied to determine the extent and rate of endocrine complications. Mean haemoglobin and ferritin concentrations were 8.8 +/- 0.6 and 3,597 +/- 1,931, respectively. Provocation tests for growth hormone secretion were applied in patients with standing heights below the third centile and/or growth ...
Aydinok, Y, Darcan, S, Polat, A, Kavakli, K, Nisli, G, Coker, M, Kantar, M, Cetingul, N   +7 more
openaire   +3 more sources

Genetic and Clinical Characteristics of Thalassemia Trait and Construction of LASSO‐Based Model for Its Differentiating From Iron Deficiency Anemia in Northern China

Journal of Clinical Laboratory Analysis, EarlyView.
This study revealed a β‐thalassemia‐trait‐dominated genetic spectrum in Northern‐Chinese patients with microcytic hypochromic anemia, with _αSEA/αα, HBB:c.316_197C>T and HBB:c.124_127delTTCT being the most prevalent α‐ and β‐globin genotypes. Using LASSO regression, we constructed a nomogram based on four routine complete‐blood‐count parameters (RBC ...
Wen‐jie Yu, Feng‐qi Zhang, Jia‐feng Niu, Rui Ma, Yin‐ting Ma, Guang‐ping Li, Yan Long   +6 more
wiley   +1 more source

Beta thalassemia major new births from 1972 to 2015.

, 2019
Beta thalassemia major new births from 1972 to 2015.
K. K. Hemantha (7256006), M. Jansz (7255970), Udaya de Silva (7255958), Mahinda Arambepola (7255982), David J. Weatherall (7177418), Upul Navarathne (7255976), Rasnayaka Mudiyanse (7255946), Sanath P. Lamabadusuriya (7255961), Nilam Jiffry (7255952), D. K. Shantha Kumara (7256000), I. Rifaya (7255973), Wijesundara Dayanada Bandara (7255985), K. Pushpakumara (7255964), U. Vaidyanatha (7255988), K. Weerasekara (7255994), Sachith Mettananda (411784), V. Thirukumaran (7255979), Angela Allen (272299), Shamila T. De Silva (7255949), Randima Dissanayaka (7255967), Sujeewa D. Amarasena (7256003), Udaya Nelumdeniya (7255955), Nalika De Silva (7255997), M. A. C. M. Refai (7256009), F. Rajiyah (7256012), Nancy F. Oliveri (7256015), Anuja P. Premawardhana (7255943), Devan Mendis (7255991), Ishari Silva (7177409), Nizri Hameed (7177412)   +29 more
core   +1 more source

Plummer–Vinson syndrome in a 10‐year‐old boy from Côte d'Ivoire: An exceptional paediatric case with African context

JPGN Reports, EarlyView.
Abstract Plummer–Vinson syndrome (PVS) is characterised by the triad of dysphagia, iron‐deficiency anaemia, and proximal oesophageal webs. While well described in adults, paediatric cases remain exceptionally rare, particularly in sub‐Saharan Africa.
Paul Mike Tayou Mbobda, Hatrydt Guillaume Dimitri Kouamé, Amadou Ouattara   +2 more
wiley   +1 more source