Results 71 to 80 of about 3,379 (229)

Preparation of betahistine-d3

, 1999
With the aim of examing the pharmacokinetics of Betahistine Deuterate- Betahistine (N-Methyl-d3-2-Pyridinethanamine dihydrochloride) has been prepared by adding Methyl-d3-Amine to 2 ...
Passarella D., Valenti M., Passarotti C. M., Martinelli M.   +3 more
core   +1 more source

Pharmacological and Mechanistic Interventions for Cognitive Impairment Associated With Schizophrenia: A Review of Registered Clinical Trials

Acta Psychiatrica Scandinavica, Volume 153, Issue 5, Page 402-431, May 2026.
ABSTRACT Background Schizophrenia is characterized by positive, negative, and cognitive symptoms. Current pharmacological treatments often fail to address cognitive deficits. In this review of clinical trials, we aim to identify studies that explore neurobiological (non‐psychological) strategies to address Cognitive Impairment Associated with ...
Bahareh Peyrovian, Lena Palaniyappan, Theodore T. Kolivakis, Howard C. Margolese   +3 more
wiley   +1 more source

Comparative Prognostic Analysis of Sudden Sensorineural Hearing Loss With Vertigo in Pediatric and Adult Patients

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 2, April 2026.
ABSTRACT Objective To compare the association of vertigo with rates of frequency‐specific hearing recovery in pediatric and adult patients with unilateral idiopathic sudden sensorineural hearing loss (SSNHL). Methods A total of 80 pediatric and 444 adult patients hospitalized with SSNHL were included in this study.
Changshuo Shan, Guohui Chen, Jin Li, Feifei Guo, Yun Gao, Jiao Zhang, Jing Guan, Dayong Wang, Qiuju Wang   +8 more
wiley   +1 more source

Comparative Effectiveness of Betahistine vs Dimenhydrinate in Reducing Dizziness Handicap Scores in Patients with Peripheral Vestibular Disorders

Medica Hospitalia : Journal of Clinical Medicine
BACKGROUND: Peripheral vestibular disorder is a disorder of the peripheral vestibular system. Its symptoms affect the quality of life from moderate to severe.
C. Nayoan, Muyassaroh Muyassaroh, Zulfikar Naftali   +2 more
semanticscholar   +1 more source

Identifying Drugs Associated With Parkinson's Disease Risk Using Machine Learning

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.
ABSTRACT Machine learning (ML)–based methods have been proposed as a potential approach for identifying candidate drugs to be repurposed as disease‐modifying treatments for Parkinson's disease (PD). We applied an ML‐based signal detection method to identify drugs associated with PD and evaluated the method's generalizability.
Eeva Pylkkö, Émeline Courtois, Anne Paakinaho, Sirpa Hartikainen, Valtteri Kaasinen, Alexis Elbaz, Anne C. M. Thiébaut, Ismaïl Ahmed, Anna‐Maija Tolppanen   +8 more
wiley   +1 more source

Persistent Postural‐Perceptual Dizziness: A Practical Approach to Diagnosis and Patient Communication

European Journal of Neurology, Volume 33, Issue 2, February 2026.
ABSTRACT Background Despite clear diagnostic criteria established in 2017, delivering and explaining the diagnosis of persistent postural‐perceptual dizziness (PPPD) can be challenging. Methods We outline a step‐by‐step approach to clearly explain the diagnosis, underlying mechanisms and treatment options to patients with PPPD, followed by a brief ...
Hüseyin Nezih Özdemir, Jasmin Charlton, Elvira Cortese, Arianna Di Stadio, David Herdman, Diego Kaski   +5 more
wiley   +1 more source

Does betahistine treatment have additional benefits to vestibular rehabilitation?

, 2010
The aim of this study was to investigate the effect of high-dose betahistine treatment added to vestibular rehabilitation (VR) on the disability, balance and postural stability in patients with unilateral vestibular disorder.
Kirazli, Yesim, Kirazli, Tayfun, Akyuz, Aycan, Eyigor, Sibel, Celebisoy, Nese, Gode, Sercan, Karapolat, Hale, Bilgen, Cem, Sibel Eyigor, Hale Karapolat, Yesim Kirazli, Tayfun Kirazli, Nese Celebisoy, Aycan Akyuz, Cem Bilgen, Sercan Gode   +15 more
core   +1 more source

Effectiveness of betahistine (48 mg/day) in patients with vestibular vertigo during routine practice: The VIRTUOSO study.

PLoS ONE, 2017
BackgroundVestibular vertigo is associated with substantially reduced quality of life. Betahistine is effective in improving vertigo-associated symptoms, with longer treatment periods leading to greater improvements; however, it is not known whether ...
Vladimir A Parfenov, Volodymyr A Golyk, Eduard I Matsnev, Svetlana V Morozova, Oleg A Melnikov, Ludmila M Antonenko, Elena E Sigaleva, Maksym I Situkho, Olena I Asaulenko, Vasyl I Popovych, Maxim V Zamergrad   +10 more
doaj   +1 more source

Effects of vestibular rehabilitation, with or without betahistine, on managing residual dizziness after successful repositioning manoeuvres in patients with benign paroxysmal positional vertigo: a protocol for a randomised controlled trial

BMJ Open, 2019
IntroductionBenign paroxysmal positional vertigo (BPPV) is recognised as the leading cause of peripheral vertigo in adults. The canalith repositioning procedure (CRP) can be used for effective treatment of BPPV. However, some patients experience residual
Peixia Wu, Wenzhu Cao, Yan Hu, Huawei Li
doaj   +1 more source

Betahistine’s Neuroprotective Actions against Lipopolysaccharide-Induced Neurotoxicity: Insights from Experimental and Computational Studies

Brain Science
Histamine H3 receptor (H3R) antagonists, such as betahistine (BHTE), have shown significant potential in treating central nervous system (CNS) disorders due to their neuroprotective properties. This study investigated BHTE’s effects on lipopolysaccharide
V. Mani, Minhajul Arfeen
semanticscholar   +1 more source