SpliCOOL‐seq achieves high‐throughput single‐cell co‐profiling of DNA methylation and chromatin accessibility. DNMT inhibitors caused cancer cell demethylation with divergent patterns. SpliCOOL‐seq enables the discovery of genes related to LUAD tumorigenesis. Ageing and LUAD tumorigenesis may share similar epigenetic alterations.
Qingmei Shen +6 more
wiley +1 more source
Betaine alleviates letrozole-induced polycystic ovarian syndrome in rats by regulating oxidative stress and inflammation and restoring the proliferation-apoptosis balance. [PDF]
Babaeenezhad E +4 more
europepmc +1 more source
Our findings indicate that ECG‐EVLP can effectively promote wound healing and the activation of the VEGF/AKT signaling pathway in vitro and in vivo, coupled with the inhibition of the mitochondrial apoptosis pathway in cells following ECG‐EVLP stimulation might be its underlying mechanism.
Yingjie Xiong +10 more
wiley +1 more source
Effect of egg consumption on circulating choline, betaine, and trimethylamine n-oxide in adults: a systematic review and meta-analysis of randomized controlled trials. [PDF]
Aryaeian N +5 more
europepmc +1 more source
Frontiers in the Management of Orthopaedic Periprosthetic Joint Infection
ABSTRACT Periprosthetic joint infection (PJI) is a devastating complication of total joint arthroplasty (TJA), one of the most frequently performed surgical procedures worldwide. Management of acute PJI commonly involves debridement, antibiotics, and implant retention (DAIR), though failure rates remain high due to antibiotic‐tolerant biofilms. Chronic
Michael F. Shannon +9 more
wiley +1 more source
Rumen microbiota-host interactions regulate intramuscular fat deposition in cattle via the alpha-linolenic acid-fatty acid β-oxidation/L-carnitine-MPO axis. [PDF]
Zhang WT +7 more
europepmc +1 more source
Starting from lignin‐derived compounds (LDCs), a library of radically polymerizable monomers are synthesized. Biobased polymers are then prepared by free radical polymerization using industrially relevant processes: in solution (ethyl lactate) and in emulsion (water). Polymers with high thermal resistance and tunable Tgs are obtained, along with stable
Joanna Michalska‐Walkowiak +5 more
wiley +1 more source
Effects of sour soup on silage fermentation performance and bacterial community of Broussonetia papyrifera. [PDF]
Cheng Q +9 more
europepmc +1 more source
Influence of pH and methylation degree on the antibacterial activity of glycine against pig specific enterotoxigenic Escherichia coli [PDF]
Janssens, Geert +4 more
core
Plant‐based fermentation matrices significantly influence microbial diversity and species‐specific proteomic adaptations. The integration of MALDI‐TOF MS and 16S rRNA sequencing with physicochemical analyses allowed for a better understanding of the impact of specific fermentation products on differences in microbial diversity and spectral protein ...
Agnieszka Ludwiczak +8 more
wiley +1 more source

