ABSTRACT Background Ovarian carcinosarcoma (OCS) is a rare, aggressive tumor composed of both carcinomatous and sarcomatous components, typically associated with poor prognosis. Due to its rarity, the molecular characteristics, immune microenvironment, and optimal treatment of OCS remain unclear.
Tomomi Sakamaki +14 more
wiley +1 more source
Reduced Local Tumor Progression After Thermal Ablation During Atezolizumab Plus Bevacizumab Treatment for Hepatocellular Carcinoma. [PDF]
Nakabori T +13 more
europepmc +1 more source
ABSTRACT Background and Aims Circulating tumor DNA (ctDNA) has emerged as a promising biomarker of tumor burden and minimal residual disease. As total neoadjuvant therapy (TNT) increasingly supports organ‐preserving strategies in locally advanced rectal cancer (LARC), reliable markers of treatment response are needed.
Faizan Bashir +4 more
wiley +1 more source
EV‐LYSG101: Extracellular Vesicles Loaded With Lysin LYSG101 for Potent Anti‐Staphylococcal Activity
ABSTRACT Biofilm‐associated staphylococcal infections remain exceptionally difficult to treat due to the presence of resilient staphylococcal biofilms and the limited effectiveness of currently available antibiotics. To combat persistent infections, providers are often forced to use prolonged courses of combination antimicrobial therapies that have ...
Dominique B. Hoelzinger +6 more
wiley +1 more source
Bacterial extracellular vesicles modulate epithelial antiviral responses via macrophage-mediated immunomodulation. [PDF]
Bierwagen J +7 more
europepmc +1 more source
ABSTRACT Chronic antibiotic‐resistant cystic fibrosis (CF) lung infections are the leading cause of death in adults with CF. Despite advances in highly effective modulator therapies, microbial communities persist in the CF lung. The pathogenesis of CF airway infections can be exacerbated by pathogens such as Pseudomonas aeruginosa, which communicates ...
Lily A. Charpentier +10 more
wiley +1 more source
Gut-derived bacterial extracellular vesicles: the microbial dark matter contributing to host inflammation and cardiometabolic disease. [PDF]
Oliver B +6 more
europepmc +1 more source
Mapping the subgingival HerBiome and HisBiome over the human healthspan
Abstract Background Understanding the intricate relationship between sex, age, and the oral microbiome is crucial for deciphering the onset and progression of numerous age‐related oral and systemic diseases. Methods Subgingival plaque was collected from 781 periodontally and systemically healthy females and 160 males spanning 0 to 80 years.
Rahul Nikam +3 more
wiley +1 more source
TriQuery-BEV: Enhancing 3D Perception for Autonomous Driving with Temporal Query Filtering and Uncertainty-Aware Fusion. [PDF]
Dong J, Chen X, Liu Z.
europepmc +1 more source
Large Language Models as Health Information Tools: Patient Use and Trust in Otolaryngology
ABSTRACT Objectives Patients increasingly use large language models (LLMs) for health information, yet their use patterns, perceptions, and impact on clinical communication in otolaryngology remain poorly characterized. Methods We conducted a cross‐sectional survey of adult patients at an academic otolaryngology clinic. The survey assessed demographics,
Beverly J. Fu +5 more
wiley +1 more source

