Results 111 to 120 of about 11,405 (213)

Differential Impact of Pharmacokinetic and Pharmacodynamic Variability on Response to Combination Therapy

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Interindividual variability (IIV) in drug response complicates both fixed‐dose design and individualized therapy. Understanding how pharmacokinetic (PK) and pharmacodynamic (PD) processes jointly shape this variability is essential, particularly in combination therapy, where multiple interacting pathways influence outcomes. This study employed
Kuteesa R. Bisaso   +3 more
wiley   +1 more source

Zero-BEV: Zero-shot Projection of Any First-Person Modality to BEV Maps

open access: yes2024 International Conference on 3D Vision (3DV)
Bird's-eye view (BEV) maps are an important geometrically structured representation widely used in robotics, in particular self-driving vehicles and terrestrial robots. Existing algorithms either require depth information for the geometric projection, which is not always reliably available, or are trained end-to-end in a fully supervised way to map ...
Gianluca Monaci   +3 more
openaire   +2 more sources

ACKR1/Duffy‐null genotype testing for clozapine: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 1977-1990, July 2026.
Abstract Clozapine is licenced for treatment‐resistant schizophrenia and psychosis in Parkinson's disease. In the United Kingdom, there is a mandatory requirement for absolute neutrophil count (ANC) and white blood cell count (WBC) monitoring to safeguard against agranulocytosis.
Stephen Murtough   +29 more
wiley   +1 more source

Feasibility Study of Combined Systemic Therapy and Carbon‐Ion Radiotherapy for Hepatocellular Carcinoma Patients

open access: yesCancer Medicine, Volume 15, Issue 7, July 2026.
ABSTRACT Background Recent advances in systemic therapy, including tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs), have improved outcomes for hepatocellular carcinoma (HCC) and enabled downstaging strategies that allow subsequent local treatments. Carbon‐ion radiotherapy (CIRT) can provide excellent tumor control with minimal
Daijiro Kobayashi   +6 more
wiley   +1 more source

PC-BEV: An Efficient Polar-Cartesian BEV Fusion Framework for LiDAR Semantic Segmentation

open access: yesProceedings of the AAAI Conference on Artificial Intelligence
Although multiview fusion has demonstrated potential in LiDAR segmentation, its dependence on computationally intensive point-based interactions, arising from the lack of fixed correspondences between views such as range view and Bird's-Eye View (BEV), hinders its practical deployment.
Shoumeng Qiu   +3 more
openaire   +2 more sources

Health Preferences and Sorting in the City

open access: yesHealth Economics, Volume 35, Issue 7, Page 1033-1055, July 2026.
ABSTRACT There are large health inequalities between neighborhoods in many cities of the world. This paper studies individuals' sorting based on health amenities and exposes an important connection between health preferences and the housing market. I estimate a neighborhood choice model using geolocated data from a health survey in New York City and ...
Manuela Puente‐Beccar
wiley   +1 more source

BEV-LIO(LC): BEV Image Assisted LiDAR-Inertial Odometry with Loop Closure

open access: yes2025 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS)
This work introduces BEV-LIO(LC), a novel LiDAR-Inertial Odometry (LIO) framework that combines Bird's Eye View (BEV) image representations of LiDAR data with geometry-based point cloud registration and incorporates loop closure (LC) through BEV image features.
Haoxin Cai   +4 more
openaire   +2 more sources

Cerebral palsy in Brazil: A multicentre, cross‐sectional, descriptive study

open access: yesDevelopmental Medicine &Child Neurology, Volume 68, Issue 7, Page 983-989, July 2026.
Main clinical and perinatal characteristics of children and adolescents with cerebral palsy from a nationwide rehabilitation network in Brazil. This original article is commented on by Cuestas on pages 883‐884 of this issue. Portuguese translation of this Original Article is available in the online issue.
Eliana Valverde Magro Borigato   +16 more
wiley   +1 more source

Higher Body Mass Index Is a Causal Risk Factor for Skin Infections: A Mendelian Randomisation Study Using UK Biobank and FinnGen

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 5907-5914, July 2026.
ABSTRACT Aims Infections remain a leading cause of mortality and morbidity globally. We aimed to evaluate the potential causal role of higher BMI on common bacterial, viral and fungal infections using Mendelian randomisation (MR). Material and Methods In UK Biobank (N = 502 131, N = 230 542 with linked GP records), we tested observational associations ...
Rhian Hopkins   +6 more
wiley   +1 more source

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