Results 61 to 70 of about 25,585 (256)

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

BMEMat, EarlyView.
Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen, Weichen Zhang, Gaoli Niu, Li Wang, Ruiyan Li, Yueyue Fan, Feixue Lu, Lingling Xu, Xiaoyuan Ji, Yong Kang   +9 more
wiley   +1 more source

S100B induces angiogenesis via the clathrin/FOXO1/β-catenin signaling pathway and contributes to Bevacizumab resistance in epithelial ovarian cancer

Journal of Advanced Research
Introduction: Bevacizumab (BEV), the most common antiangiogenic agent for treating ovarian cancer, prolongs progression-free survival (PFS) but does not significantly improve overall survival (OS).
Haoya Xu, Wenzhi Li, Huiran Yue, Yang Bai, Jun Li, Xin Lu, Jieyu Wang   +6 more
doaj   +1 more source

Optimal Scheduling of Bevacizumab and Pemetrexed/Cisplatin Dosing in Non‐Small Cell Lung Cancer

CPT: Pharmacometrics & Systems Pharmacology, 2019
Bevacizumab‐pemetrexed/cisplatin (BEV‐PEM/CIS) is a first‐line therapeutic for advanced nonsquamous non‐small cell lung cancer. Bevacizumab potentiates PEM/CIS cytotoxicity by inducing transient tumor vasculature normalization.
Benjamin K. Schneider, Arnaud Boyer, Joseph Ciccolini, Fabrice Barlesi, Kenneth Wang, Sebastien Benzekry, Jonathan P. Mochel   +6 more
doaj   +1 more source

Harnessing bacterial extracellular vesicles for bone and cartilage organoids

BMEMat, EarlyView.
This review presents bacterial extracellular vesicles (BEVs) as programmable bioactive regulators for bone and cartilage organoids by delivering functional cargos that modulate skeletal remodeling. It highlights key engineering strategies and future directions to advance next‐generation organoid models for bone aging related diseases.
Han Liu, Xukun Lv, Ting Cheng, Lei Yan, Yuxiao Lai, Keying Guo, Yingying Jing, Hao Shen, Jiacan Su   +8 more
wiley   +1 more source

Recurrent colon perforation after discontinuation of bevacizumab for ovarian cancer

Gynecologic Oncology Reports, 2018
Bevacizumab (Bev) is an antiangiogenic drug used to treat various malignances, including ovarian cancer (OC). Bev is generally well-tolerated; however, it has a characteristic toxicity profile.
Michiko Nonaka, Seiya Sato, Daiken Osaku, Mayumi Sawada, Akiko Kudoh, Jun Chikumi, Shinya Sato, Tetsuro Oishi, Tasuku Harada   +8 more
doaj   +1 more source

Evaluation of Circular Pathways for Heavy‐Duty Vehicle Batteries in Europe Using a Multi‐Method Simulation Approach

Business Strategy and the Environment, EarlyView.
ABSTRACT Circular battery strategies have become of major interest focusing on material availability while increasing economic and environmental benefits. In this context of circular economy, one main challenge for automotive original equipment manufacturers is that the most profitable handling strategy along the lifecycle is unknown.
Michael Lieder, Farazee Mohammad Abdullah Asif, Amir Rashid   +2 more
wiley   +1 more source

R3-BEV: Routing, Rasterization, and Reliability-Aware Fusion for Radar-Camera 3-D Object Detection

IEEE Access
3D object detection is a fundamental task in autonomous driving. Although multi-view camera-based BEV methods have achieved strong performance, they remain limited in long-range scenes, adverse illumination, and motion-aware perception.
Jinhao Li, Xueying Bai, Quanyi Liu, Shenghua Xiong, Zerong Zhao, Tianbin Huang, Haibin Wang   +6 more
doaj   +1 more source

Bacterial extracellular vesicles: A position paper by the microbial vesicles task force of the Chinese society for extracellular vesicles

Interdisciplinary Medicine, 2023
Recently, the interest in extracellular vesicles released by bacteria has rapidly increased. Bacterial extracellular vesicles (BEVs) have been involved in bacteria‐bacteria and bacteria‐host interactions, which strengthen health or bring about various ...
Minghui Wen, Jingyu Wang, Zihao Ou, Guangjun Nie, Ye Chen, Min Li, Zhiwei Wu, Sidong Xiong, Hongwei Zhou, Zifeng Yang, Gang Long, Jiacan Su, Han Liu, Yingying Jing, Zhenke Wen, Yuxuan Fu, Tieli Zhou, Hui Xie, Wenda Guan, Xi Sun, Zhang Wang, Juan Wang, Xunxun Chen, Linglei Jiang, Xiaolin Qin, Yicong Xue, Mei Huang, Xinyue Huang, Ruoru Pan, Haojun Zhen, Yuqi Du, Qianbei Li, Xixin Huang, Yuanyuan Wu, Pingping Wang, Kening Zhao, Bo Situ, Xiumei Hu, Lei Zheng   +38 more
doaj   +1 more source

Feasibility and Procedural Considerations of Balloon‐Expandable TAVR in Patients With Prior Endovascular Aortic Stent Grafts

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Objectives To evaluate the feasibility and short‐term outcomes of transcatheter aortic valve replacement (TAVR) using balloon‐expandable Sapien valves in patients with prior endovascular aortic stent grafts. Methods We conducted a single‐center, retrospective study of 23 patients with prior endovascular aortic stent grafts who underwent TAVR ...
Iad Alhallak, Alexander Mills, Beau Bequeaith, Ken Chan, Akiko Tanaka, Anthony L. Estrera, Biswajit Kar, Richard Smalling, Abhijeet Dhoble   +8 more
wiley   +1 more source

Mechanisms and Management of Acquired Aseptic Intracardiac Communications After Transcatheter Aortic Valve Implantation: Single‐Center Case Series Insights

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Acquired aseptic intracardiac communications (AICCs) are rare but clinically relevant structural complications following transcatheter aortic valve implantation (TAVI), typically resulting from mechanical injury to the aortic annulus, interventricular septum, or adjacent structures.
Geza Fontos, Abdelkrim Ahres, Marton Vertesaljai, Tunde Pinter, Zsolt Piroth, Matyas Pal, Peter Andreka   +6 more
wiley   +1 more source