Results 271 to 280 of about 176,622 (333)

Hepatoid Carcinoma of the Ovary: Case Report, Clinical Management, and Insights From Literature Review

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Hepatoid carcinoma of the ovary (HCO) is an exceedingly rare epithelial ovarian malignancy demonstrating hepatocellular differentiation and marked serum AFP elevation. Due to its rarity, existing literature remains limited, and optimal management strategies remain undefined. Emerging evidence highlights the urgent need for improved recognition
Nan Zhang, Zhilan Liu, Dengfeng Cao, Weihua Lou   +3 more
wiley   +1 more source

Unexpected Long-Term Disease Control in Lung Cancer With Sacral Metastases After Conventional Radiotherapy and Chemotherapy Despite Discontinuation of Maintenance Therapy: A Case Report. [PDF]

Clin Case Rep
Bayani R, Khakpour M, Jahanbin B, Darzikolaee NM.   +3 more
europepmc   +1 more source

Chemoradiotherapy with temozolomide vs. radiotherapy alone in patients with IDH wild‐type and TERT promoter mutation histological grade 2/3 gliomas: An extension retrospective analysis of a randomized controlled trial

Cancer, Volume 131, Issue 23, 1 December 2025.
Abstract Background Given the poor prognosis of IDH wild‐type (IDH‐wt) and telomerase reverse transcriptase promoter mutation (TERTp‐mut) histological grade 2 to 3 gliomas, the World Health Organization has reclassified it as molecular glioblastoma. However, the effectiveness of chemoradiotherapy (CRT) in these patients remains unclear, especially in ...
Jing Zhang, Peng Wang, Yin Ren, Li Chen, Jin Feng, Fei Liu, Kaiwen Deng, Zhaoshi Bao, Xiaoguang Qiu, Yanwei Liu   +9 more
wiley   +1 more source

Nasal Septal Perforation and Hereditary Hemorrhagic Telangiectasia: Evolution in Management. [PDF]

Laryngoscope Investig Otolaryngol
Bansberg SF, House T, Lal D, Marino MJ, Taylor CM, Miglani A.   +5 more
europepmc   +1 more source

Hepatocellular Carcinoma With Small Bowel Metastasis and Intussusception: A Case Report and Literature Review

Cancer Reports, Volume 8, Issue 12, December 2025.
ABSTRACT Background Hepatocellular carcinoma (HCC) is a common primary liver malignancy. Despite advancements in treatment, HCC often has a poor prognosis because of frequent recurrence and metastasis. Hematogenous metastasis to the gastrointestinal tract is uncommon, and metastasis to the small intestine is particularly rare.
Meng‐Kai Hsu, Po‐Da Chen, Yao‐Ming Wu   +2 more
wiley   +1 more source

Nab-paclitaxel plus bevacizumab for patients with metastatic extrapulmonary neuroendocrine carcinoma: a phase 2 single-arm study. [PDF]

EClinicalMedicine
Zhang P, Li S, Jia R, Hao J, Chen C, Gan S, Li J, Shen L, Lu M.   +8 more
europepmc   +1 more source

The Evaluation of Diagnostic, Prognostic, and Predictive Role of Hematologic Inflammatory Indices NLR, PLR, and LMR in Common Solid Tumors

Cancer Reports, Volume 8, Issue 12, December 2025.
ABSTRACT Background Solid tumors are one of the leading causes of cancer‐related deaths. Measurable combined inflammatory markers in the blood, which indicate the inflammatory response, play a crucial role in managing patients with malignancies. These markers have been validated as less invasive, practical, and cost‐effective tools in the clinical ...
Fatemeh Arianmanesh, Saeede Bagheri, Mohammad Ali Karimi, Saba Izadi, Mohammad Hossein Ahmadi   +4 more
wiley   +1 more source

Two Cases of Epidermal Growth Factor Receptor L861R Mutation‐Positive Lung Adenocarcinoma Treated With Osimertinib and Afatinib

Cancer Reports, Volume 8, Issue 12, December 2025.
ABSTRACT Background Epidermal growth factor receptor (EGFR) mutations are detected in approximately 40%–50% of patients with lung adenocarcinoma in Asian populations and in around 10% of patients in Western populations. Among these, the EGFR L861R mutation is uncommon and undetectable using conventional polymerase chain reaction methods.
Kei Kagawa, Takeshi Masuda, Kiyofumi Shimoji, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Taku Nakashima, Hiroshi Iwamoto, Hironobu Hamada, Noboru Hattori   +9 more
wiley   +1 more source

Antiangiogenic Treatment of Patients with Hereditary Hemorrhagic Telangiectasia: Experience of a Hungarian Center. [PDF]

J Clin Med
Brugós B, Csirmaz A, Major T, Bereczky Z, Gindele R, Balogh G, Kacska S, Sipos P, Illés Á, Pfliegler G.   +9 more
europepmc   +1 more source

Reprogramming the tumour microenvironment: Emerging strategies to overcome immunotherapy resistance

Clinical and Translational Discovery, Volume 5, Issue 6, December 2025.
Reprogramming the tumour microenvironment (TME) overcomes immunotherapy resistance by targeting immunosuppressive cells, abnormal vasculature and metabolic dysregulation. Emerging strategies, including epigenetic modulation, vascular normalisation and cellular therapies, transform the TME into an immune‐active landscape, enhancing T‐cell infiltration ...
Mohammed Elmujtba Adam Essa, Shahd Elbadri, Abdelkareem A. Ahmed, Hamid Noori   +3 more
wiley   +1 more source