Results 271 to 280 of about 178,774 (332)

Enhancing the efficacy of VEGF inhibitors by co-inhibition of HIF in the treatment of glioblastoma. [PDF]

Apoptosis
Harbi E, Byrne YY, Bozbey HU, Tastekin D, Oncul O, Hosseiny S, Yahya D, Yildiz O, Erdogan M, Slocum AK, Mason CE, Aschner M.   +11 more
europepmc   +1 more source

Isoquercetin and Zafirlukast Cooperatively Suppress Tumor Growth and Thromboinflammatory Signaling in a Xenograft Model of Ovarian Cancer

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Treatment using either the thiol isomerase inhibitor isoquercetin or zafirlukast lowers tissue factor levels, decreases VEGF, inhibits PD‐L1, and TMEM176B in a xenograft model of ovarian cancer. A combination of the two agents, at threefold lower concentrations than either drug, significantly enhanced the inhibition further, suggesting a dual action of
Justine A. Keovilay, Jason W. Hoskins, Jean‐Pierre Kinet, Thomas C. Lines, Daniel R. Kennedy   +4 more
wiley   +1 more source

Cytotoxic Effects of Sorafenib, Lapatinib, and Bevacizumab, Alone and in Combination, on Medullary Thyroid Carcinoma Cells. [PDF]

Curr Oncol
Altun G, Yönem Ö.
europepmc   +1 more source

Bioorthogonal Chemistry in Biomolecule Quantification: A Review of Reactions and Strategies

Chemistry – A European Journal, Volume 32, Issue 1, 2 January 2026.
This review summarizes the application of catalyst‐free bioorthogonal reactions: Staudinger ligation, strain promoted azide alkyne cycloaddition, inverse electron‐demand Diels–Alder, and 2‐cyanobenzothiazole cysteine condensation in the semi‐quantitative and quantitative analysis of biomolecules.
Mingze Yang, Shiqi Wang
wiley   +1 more source

Association between induced organ atrophy assessed by artificial intelligence-generated automatic segmentation and efficacy of bevacizumab in combination with chemotherapy in metastatic colorectal cancer. [PDF]

Cancer Imaging
Laich M, Brugel M, Conze PH, Abbas M, Abdelghanie MB, Khemissa F, Kircher S, Le Malicot K, Lepage C, Aparicio T, Hoeffel C, Bouché O, Carlier C.   +12 more
europepmc   +1 more source

Prickle4 Drives Microenvironmental Remodeling and Resistance to Parp Inhibition in IDH‐Mutant Glioma

Advanced Science, Volume 13, Issue 3, 14 January 2026.
IDH‐mutant gliomas exhibit sensitivity to PARP inhibitors (PARPi) owing to oncometabolite 2‐HG‐induced DNA repair defects. PARPi treatment induces resistance by upregulating Prickle4, which promotes VEGF‐driven angiogenesis. Combining PARPi veliparib with anti‐angiogenic lenvatinib blocks this pathway, causing tumor regression and prolonged survival in
Ju Yang, Hua Yang, Yifan Yuan, Chenyang Zhang, Ziwei Fu, Yanyan Chen, Yinghong Xiong, Shuyu Chen, Kexin Ling, Ying Liu, Jason T. Huse, Bo Chen, Timothy A. Chan, Zengxin Qi, Zhao Zhang, Xiuping Liu, Yuxiang Wang   +16 more
wiley   +1 more source

Wide-Field Imaging of Retinal Vascular Macroaneurysm Associated With Retinal Racemose Hemangioma. [PDF]

Case Rep Ophthalmol Med
Katsura Y, Fukuyama H, Gomi F.
europepmc   +1 more source

Inflammatory Responsive Hydrogels Incorporated with Bevacizumab-Loaded Infinite Coordination Nanopolymers for Accelerating Cartilage Repair

Hai‐Ning Chen, Tao Xin, Jinbo Liu, Qian Kong, Li Wang, Yiwen Zhao, Chao Jiang, Yu Song, Xu Xu, Jinjian Zhu, Yiyang Wang, F. Du, Baoding Chen, Jun Wu   +13 more
openalex   +1 more source

Continuous Suppression of Pathological Retinal and Choroidal Neovascularization in Cynomolgus Monkeys via Noninvasive Ophthalmic Delivery of a Novel Anti‐VEGFA Nanobody and Proprietary Penetratin Analog Formulation

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Pathological retinal/choroidal neovascularization drives vision loss in DR and AMD. Current anti‐VEGF injections, while effective, require invasive, frequent administration. Pene/LQ015, is developed a novel topical anti‐VEGFA nanobody formulation achieving therapeutic intraocular levels through penetratin analog‐enhanced delivery.
Chong Chen, Min Zhu, Xingyan Fan, Kangjia Lv, Kuan Jiang, Yuchen Zhang, Haoliang Zhang, Xinming Qi, Benjamin TK Lee, Yakun Wan, Gang Wei, Kun Liu, Xun Xu   +12 more
wiley   +1 more source

Rapid expression of therapeutic antibodies in mammalian cells via mRNA transfection. [PDF]

MAbs
Chavalparit T, Barry C, Gunter H, Gillard M, Mercer T, Marcellin E.   +5 more
europepmc   +1 more source