Results 101 to 110 of about 5,330,848 (365)

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Ultraviolet completion of a composite asymmetric dark matter model with a dark photon portal

Journal of High Energy Physics, 2019
Composite asymmetric dark matter scenarios naturally explain why the dark matter mass density is comparable with the visible matter mass density. Such scenarios generically require some entropy transfer mechanism below the composite scale; otherwise ...
Masahiro Ibe, Ayuki Kamada, Shin Kobayashi, Takumi Kuwahara, Wakutaka Nakano   +4 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Lepto-axiogenesis

Journal of High Energy Physics, 2021
We propose a baryogenenesis mechanism that uses a rotating condensate of a Peccei-Quinn (PQ) symmetry breaking field and the dimension-five operator that gives Majorana neutrino masses.
Raymond T. Co, Nicolas Fernandez, Akshay Ghalsasi, Lawrence J. Hall, Keisuke Harigaya   +4 more
doaj   +1 more source

Charm mixing in the Standard Model and beyond [PDF]

, 2006
The motivation most often cited in searches for D0-anti-D0 mixing and CP-violation in charm system lies with the possibility of observing a signal from New Physics which dominates that from the Standard Model. We review recent theoretical predictions and
ALEXEY A. PETROV, Yao W. M.
core   +3 more sources

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Running of fermion observables in non-supersymmetric SO(10) models

Journal of High Energy Physics, 2018
We investigate the complete renormalization group running of fermion observables in two different realistic non-supersymmetric models based on the gauge group SO(10) with intermediate symmetry breaking for both normal and inverted neutrino mass orderings.
Tommy Ohlsson, Marcus Pernow
doaj   +1 more source

Nucleation is more than critical: A case study of the electroweak phase transition in the NMSSM

Journal of High Energy Physics, 2021
Electroweak baryogenesis is an attractive mechanism to generate the baryon asymmetry of the Universe via a strong first order electroweak phase transition.
Sebastian Baum, Marcela Carena, Nausheen R. Shah, Carlos E. M. Wagner, Yikun Wang   +4 more
doaj   +1 more source

Recent Developments in Physics Beyond the Standard Model [PDF]

, 1999
In this talk I discuss some recent developments in physics beyond the Standard Model. After some initial comments on neutrino masses, I discuss the status of low-energy supersymmetry and finally turn to describing some recent work in theories with extra ...
Giudice, G. F.
core   +3 more sources

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source