Results 41 to 50 of about 78,901 (143)

Taipan Natriuretic Peptides Are Potent and Selective Agonists for the Natriuretic Peptide Receptor A

Molecules, 2023
Cardiovascular ailments are a major cause of mortality where over 1.3 billion people suffer from hypertension leading to heart-disease related deaths. Snake venoms possess a broad repertoire of natriuretic peptides with therapeutic potential for treating
Simone Vink, Kalyana Bharati Akondi, Jean Jin, Kim Poth, Allan M. Torres, Philip W. Kuchel, Sandra L. Burke, Geoffrey A. Head, Paul F. Alewood   +8 more
doaj   +1 more source

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source

Neurocardiology: Brain–Heart Interactions in the Heart

MedComm, Volume 7, Issue 9, September 2026.
The heart and brain maintain systemic homeostasis through bidirectional communication involving neural, biochemical, and mechanical pathways. Dysregulation of these pathways contributes to a spectrum of conditions involving heart–brain interactions, including Takotsubo syndrome, the epileptic heart, stroke–heart syndrome, heart failure, cardiac ...
Wentao Wang, Hao Jia, Han Han, Jiangping Song   +3 more
wiley   +1 more source

Microinjection of a 5-HT3 receptor agonist into the NTS of awake rats inhibits the bradycardic response to activation of the von Bezold-Jarisch reflex

, 2001
International audienceIn the present study we investigated the effects of bilateral microinjection into the lateral commissural nucleus tractus solitarius (NTS) of 2-methyl-5-HT, a 5-HT3 receptor agonist, on the bradycardic response of the von Bezold ...
Callera, João Carlos, Machado, Benedito H., Laguzzi, Raul, Bonagamba, Leni G.H, Leal, Daniel M., Nosjean, Anne   +5 more
core   +1 more source

Successful Cardiopulmonary Resuscitation in a Sevoflurane Anaesthetized Horse That Suffered Cardiac Arrest at Recovery

Frontiers in Veterinary Science, 2018
A 17-year-old mare undergoing dental surgery suffered a cardiac arrest while being transferred from the surgical theatre to the recovery box. This complication was diagnosed early, thus allowing a prompt start to the cardiopulmonary resuscitation ...
Clara Conde Ruiz, Stéphane Junot, Stéphane Junot   +2 more
doaj   +1 more source

Evaluation of the Effects of Ondansetron Administration in the ERAS Protocol on Regional Anesthesia in Cesarean Surgeries: A Prospective Randomized Study

Bagcilar Medical Bulletin, 2022
Objective:The enhanced recovery after surgery protocol has been applied more frequently in cesarean surgeries, and regional anesthesia is the first choice because of its postoperative advantages.
Necmiye Ay, Duygu Akyol, Pelin Kılıç Erol, İbrahim Polat   +3 more
doaj   +1 more source

Physiologically‐Guided Ultrafiltration: A Proposed Ultrasound Framework for Individualized Volume Removal During Hemodialysis

Nephrology, Volume 31, Issue 9, September 2026.
ABSTRACT Ultrafiltration during hemodialysis is the most hemodynamically stressful intervention dialysis patients endure, yet its prescription relies on interdialytic weight gain and clinical gestalt. Rates exceeding 13 mL/kg/h carry substantially higher cardiovascular mortality, and recurrent intradialytic hypotension drives myocardial stunning ...
Sharad Patel, Arwa Bootwala, Adam Green
wiley   +1 more source

Neural reflex regulation of arterial pressure in pathophysiological conditions: interplay among the baroreflex, the cardiopulmonary reflexes and the chemoreflex

Brazilian Journal of Medical and Biological Research, 1997
The maintenance of arterial pressure at levels adequate to perfuse the tissues is a basic requirement for the constancy of the internal environment and survival.
E.C. Vasquez, S.S. Meyrelles, H. Mauad, A.M. Cabral   +3 more
doaj   +1 more source

Haemodynamic‐energetic mechanism of sudden cardiac death in severe aortic stenosis: A modelling study

The Journal of Physiology, Volume 604, Issue 13, Page 5458-5492, 1 July 2026.
Abstract figure legend A sudden decrease in total peripheral resistance (TPR), as observed during vasovagal syncope, leads to a reduction in aortic systolic pressure (AO pressure) and afterload. In healthy individuals, the consequent decrease in left ventricular systolic pressure (LV pressure) lowers stroke work and myocardial energy expenditure.
Martin Dvoulety, Michal Sitina
wiley   +1 more source

A case of hypotension after intranasal adrenaline infiltration causing a clinical dilemma during the intraoperative period

Indian Journal of Anaesthesia, 2011
Solutions containing adrenaline are widely used for presurgical infiltration. Haemodynamic changes associated with its use are well documented in the literature.
Shyam Bhandari, Mozammil Shaffi, S Bano, Suhail Sarwar Siddiqui, Jahangir Ahmad   +4 more
doaj   +1 more source