Results 41 to 50 of about 1,099,800 (297)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Regression Models and Fuzzy Logic Prediction of TBM Penetration Rate
Open Engineering, 2017 This paper presents statistical analyses of rock engineering properties and the measured penetration rate of tunnel boring machine (TBM) based on the data of an actual project.
Minh Vu Trieu +3 more
doaj +1 more source
covsim: An R Package for Simulating Non-Normal Data for Structural Equation Models Using Copulas
Journal of Statistical Software, 2022 In factor analysis and structural equation modeling non-normal data simulation is traditionally performed by specifying univariate skewness and kurtosis together with the target covariance matrix.
Steffen Grønneberg +2 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
DEVELOPMENT OF ERP AND OTHER LARGE BUSINESS SYSTEMS IN THE CONTEXT OF NEW TRENDS AND TECHNOLOGIES
Vallis Aurea, 2017 This paper presents an overview of terms, concepts, trends and technologies that are relevant to today's business. It describes the basics of data and information integration and flow in a company through a central ERP system with concepts of CRM and SCM.
Sabrina Suman, Ivan Pogarcic
doaj +1 more source
Magma, 2020 Denne artikkelen diskuterer hvordan man kan kombinere vertikalt og horisontalt lederskap effektivt i prosjekter, altså hvordan lederskapet i prosjektet kan skifte mellom teammedlemmer og den formelt utpekte prosjektlederen avhengig av situasjonens krav.
Anne Live Vaagaasar, Ralf Müller
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Bis(adeninium) bis(hydrogensulfate) sulfate [PDF]
Acta Crystallographica Section E Structure Reports Online, 2012 تم تصنيع مركب العنوان، 2C5H7N5 (2+)·2HSO4(-) · SO4 (2 -)، من الأدينين وحمض الكبريتيك. تحتوي الوحدة غير المتماثلة على اثنين من كاتيونات الأدينينيوم ثنائية البروتونات، واثنين من الأنيونات ثنائية الكبريتات وأنيونات كبريتات واحدة. يتم تثبيت البنية البلورية من خلال الروابط الهيدروجينية الكلاسيكية N - H? O و O - H? O، والروابط الهيدروجينية الضعيفة C - H? O و
Fatiha Guenifa +4 more
openaire +3 more sources
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source