Results 61 to 70 of about 341,687 (247)
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Technical Note: Bias correcting climate model simulated daily temperature extremes with quantile mapping [PDF]
Hydrology and Earth System Sciences, 2012 When applying a quantile mapping-based bias correction to daily temperature extremes simulated by a global climate model (GCM), the transformed values of maximum and minimum temperatures are changed, and the diurnal temperature range (DTR) can become ...
B. Thrasher +3 more
doaj +1 more source
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
Atmosphere, 2017 This study explored the potential for bias correction of global precipitation datasets (GPD) to support streamflow simulation for water resource management in data limited regions.
Alexander J. Koutsouris +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Assessing atmospheric bias correction for dynamical consistency using potential vorticity
Environmental Research Letters, 2014 Correcting biases in atmospheric variables prior to impact studies or dynamical downscaling can lead to new biases as dynamical consistency between the ‘corrected’ fields is not maintained. Use of these bias corrected fields for subsequent impact studies
Eytan Rocheta +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Small sample bias correction or bias reduction?
Communications in Statistics - Simulation and Computation, 2019 Many problems in biomedical and other sciences are subject to biased estimates (maximum likelihood or of similar types). In two seminal papers Cox and Snell (1968) and Firth (1993) deal with first order bias of maximum likelihood estimates. Cox and Snell obtain a correction term that corrects, approximately, first order bias and Firth uses an ...
Xuemao Zhang, Sudhir Paul, You-Gan Wang
openaire +5 more sources
AdamD: Improved bias-correction in Adam
CoRR, 2021 Here I present a small update to the bias-correction term in the Adam optimizer that has the advantage of making smaller gradient updates in the first several steps of training. With the default bias-correction, Adam may actually make larger than requested gradient updates early in training.
openaire +2 more sources