Results 71 to 80 of about 1,818,251 (309)
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Modeling and Correcting Bias in Sequential Evaluation
Proceedings of the 24th ACM Conference on Economics and Computation, 2023 We consider the problem of sequential evaluation, in which an evaluator observes candidates in a sequence and assigns scores to these candidates in an online, irrevocable fashion. Motivated by the psychology literature that has studied sequential bias in such settings -- namely, dependencies between the evaluation outcome and the order in which the ...
Jingyan Wang 0001, Ashwin Pananjady
openaire +2 more sources
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Bias-correction methods applied to the naïve calculation of SI expressed in bit/sec.
, 2022 (A) Applying shuffle-based bias-correction methods to the naïve SI (blue) of simulated place cells expressed in bit/sec. SSR (magenta) is more accurate than SR (red) in estimating the true SI (cyan). Shuffle SI is shown in black.
Alon Rubin (12078313) +2 more
core +1 more source
Advances in mitigating InSAR non-closure phase bias: A refined processing approach
Science of Remote SensingInterferometric synthetic aperture radar (InSAR) phase bias, most commonly observed in short-term, multilooked interferograms, can significantly impact the accuracy of ground displacement measurements, particularly in regions with vegetation or temporal ...
Yasser Maghsoudi +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Bias of Maximum-Likelihood estimates in logistic and Cox regression models: A comparative simulation study [PDF]
, 2003 Parameter estimates of logistic and Cox regression models are biased for finite samples. In a simulation study we investigated for both models the behaviour of the bias in relation to sample size and further parameters.
Lenz-Tönjes, Rebecca +7 more
core +1 more source
Technical Note: Bias correcting climate model simulated daily temperature extremes with quantile mapping [PDF]
Hydrology and Earth System Sciences, 2012 When applying a quantile mapping-based bias correction to daily temperature extremes simulated by a global climate model (GCM), the transformed values of maximum and minimum temperatures are changed, and the diurnal temperature range (DTR) can become ...
B. Thrasher +3 more
doaj +1 more source