Results 111 to 120 of about 6,035,490 (336)
Mendelian randomization study of inflammatory bowel disease and bone mineral density
BMC Medicine, 2020 Background Recently, the association between inflammatory bowel disease (including ulcerative colitis and Crohn’s disease) and BMD has attracted great interest in the research community. However, the results of the published epidemiological observational
Fashuai Wu +3 more
doaj +1 more source
On Nearly Balanced Designs for Sensory Trials [PDF]
In sensory experiments, often designs are used that are balanced for carryover effects. It is hoped that this controls for possible carryover effects, like, e.g., a lingering taste of the products. Proper randomization is essential to guarantee the usual
Kunert, Joachim, Sailer, Oliver
core
Biased random-key genetic algorithms: A review
European Journal of Operational ResearchThis paper is a comprehensive literature review of Biased Random-Key Genetic Algorithms (BRKGA). BRKGA is a metaheuristic that employs random-key-based chromosomes with biased, uniform, and elitist mating strategies in a genetic algorithm framework.
Mariana A. Londe +3 more
openaire +3 more sources
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Interval-cohort designs and bias in the estimation of per-protocol effects: a simulation study
Trials, 2019 Background Randomized trials are considered the gold standard for making inferences about the causal effects of treatments. However, when protocol deviations occur, the baseline randomization of the trial is no longer sufficient to ensure unbiased ...
Jessica G. Young +3 more
doaj +1 more source
Properly Quantized History Dependent Parrondo Games, Markov Processes, and Multiplexing Circuits [PDF]
, 2009 In the context of quantum information theory, "quantization" of various mathematical and computational constructions is said to occur upon the replacement, at various points in the construction, of the classical randomization notion of probability ...
Bleiler, Steven A., Khan, Faisal Shah
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source