Results 71 to 80 of about 6,035,490 (336)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Mendelian randomization study of telomere length and lung cancer risk in East Asian population
Cancer Medicine, 2019 Associations between telomere length and cancer risk have been investigated in many epidemiological studies, but the results are controversial. These associations may be biased by reverse causation or confounded by environmental exposures.
Xuguang Cao +12 more
doaj +1 more source
Frontiers in Genetics, 2021 BackgroundIn two-sample Mendelian randomization (MR) studies, sex instrumental heterogeneity is an important problem needed to address carefully, which however is often overlooked and may lead to misleading causal inference.MethodsWe first employed cross-
Yixin Gao +6 more
doaj +1 more source
Confinement by biased velocity jumps: aggregation of Escherichia coli [PDF]
, 2014 We investigate a linear kinetic equation derived from a velocity jump process modelling bacterial chemotaxis in the presence of an external chemical signal centered at the origin.
Calvez, Vincent +2 more
core +5 more sources
Biased random walks on random graphs
, 2014 Survey based one of the topics programmed for the St Petersburg School in Probability and Statistical Physics of June 2012.
Arous, Gerard Ben, Fribergh, Alexander
openaire +2 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Incidence of Postoperative Pain after Single Visit and Two Visit Root Canal Therapy: A Randomized Controlled Trial [PDF]
Journal of Clinical and Diagnostic Research, 2016 Introduction: Root Canal Treatment (RCT) has become a mainstream procedure in dentistry. A successful RCT is presented by absence of clinical signs and symptoms in teeth without any radiographic evidence of periodontal involvement.
Avinash A. Patil +3 more
doaj +1 more source
Handling Covariates in the Design of Clinical Trials
, 2011 There has been a split in the statistics community about the need for taking covariates into account in the design phase of a clinical trial. There are many advocates of using stratification and covariate-adaptive randomization to promote balance on ...
Rosenberger, William F. +1 more
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Translational PsychiatryAlzheimer’s disease is one of the most important health-care challenges in the world. For decades, numerous efforts have been made to develop therapeutics for Alzheimer’s disease, but most clinical trials have failed to show significant treatment effects
Caihua Wang +6 more
doaj +1 more source