Results 81 to 90 of about 6,035,490 (336)
Molecular Autism, 2022 Background There has been a growing interest in the association between maternal levels of vitamin D during pregnancy and offspring autism. However, whether any associations reflect causal effects is still inconclusive.
Paul Madley-Dowd +9 more
doaj +1 more source
Frontiers in Genetics, 2022 Since the start of the COVID-19 global pandemic, our understanding of the underlying disease mechanism and factors associated with the disease severity has dramatically increased.
M. Reza Jabalameli, Zhengdong D. Zhang
doaj +1 more source
Universality of Long-Range Correlations in Expansion-Randomization Systems
, 2005 We study the stochastic dynamics of sequences evolving by single site mutations, segmental duplications, deletions, and random insertions. These processes are relevant for the evolution of genomic DNA.
Graur D +7 more
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Cross-fitted instrument: A blueprint for one-sample Mendelian randomization.
PLoS Computational Biology, 2022 Bias from weak instruments may undermine the ability to estimate causal effects in instrumental variable regression (IVR). We present here a new approach to handling weak instrument bias through the application of a new type of instrumental variable ...
William R P Denault +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Design and Analysis of Experiments in Networks: Reducing Bias from Interference [PDF]
arXiv.org, 2014 Estimating the effects of interventions in networks is complicated due to interference, such that the outcomes for one experimental unit may depend on the treatment assignments of other units.
Dean Eckles, B. Karrer, J. Ugander
semanticscholar +1 more source
Biases in Randomized Trials [PDF]
Epidemiology, 2017 Trialists and epidemiologists often employ different terminology to refer to biases in randomized trials and observational studies, even though many biases have a similar structure in both types of study. We use causal diagrams to represent the structure of biases, as described by Cochrane for randomized trials, and provide a translation to the usual ...
Mansournia, Mohammad Ali +3 more
openaire +4 more sources
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
BMC Medical Education, 2019 Background Frequent and repeated visits from patients with mental illness or free medical care recipients may elicit physicians’ negative emotions and influence their clinical decision making.
Yosuke Yamauchi +10 more
doaj +1 more source