Results 131 to 140 of about 289,968 (296)
A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints
Advanced Science, EarlyView.ARESEC is a synthetic platform that reconstructs functional V(D)J recombination in HEK293T cells. By introducing RSS elements and co‐expressing RAG1/2 and TdT across all three antibody CDRs, it enables programmable junctional diversification and direct generation of high‐affinity variants targeting PD‐1/PD‐L1, overcoming the evolutionary constraints of
Wang Liu +3 more
wiley +1 more source
Bicarbonate transport by amphibian nephron
, 1986 To determine the site of bicarbonate reabsorption, tubular fragments from five different segments of the salamander nephron (Ambystoma) were perfused in vitro.
L. C. Stoner, C. B. Yucha
core +1 more source
Electrocatalytic C─C Bond Formation Via Cyanide Interception of CO2 Reduction Intermediates
Advanced Science, EarlyView.ABSTRACT Electrochemical CO2 reduction offers a sustainable route to convert greenhouse gas into high‐value‐added chemicals, yet product distributions remain largely limited to simple C1‐C3 molecules. Here, we report a new reaction in which CO2 reduction intermediates undergo direct C‐C coupling with an external carbon nucleophile under electrochemical
Gongbo Liu +10 more
wiley +1 more source
Plant Signaling & BehaviorCardamine violifolia (C. violifolia), a hyperaccumulator selenium plant species, is a common medicinal and edible species as the primary source of Se supplementation in karst areas.
Juyue Xiao +6 more
doaj +1 more source
Advanced Science, EarlyView.A microfluidic Herd‐Immunity‐on‐a‐Chip experimentally recreates structured contact networks to quantify viral transmission dynamics. By controlling susceptible, infected, and non‐susceptible populations, the platform reveals how contact topology governs the reproduction number, outbreak propagation, herd‐immunity–like behavior, and intervention ...
Jiande Zhang +6 more
wiley +1 more source
Regulation of bicarbonate transport in rabbit ileum: pH stat studies
, 1989 Although it is well recognized that the ileum secretes bicarbonate, understanding of the mechanisms of the transport of this ion has been limited by the inability to measure fluxes in vitro.
J. H. Sellin, R. Desoignie
core +1 more source
Advanced Science, EarlyView.Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke +10 more
wiley +1 more source
Advanced Science, EarlyView.The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English +9 more
wiley +1 more source
Advanced Science, EarlyView.In this work, we constructed an ultrathin two‐dimensional (2D) In2O3 nanosheet (In2O3‐Ns) structure based on oxygen vacancies (OV)‐rich defects and low crystallinity to anchor Cu single atoms (Cu SAs) and synthesized Cu/In2O3‐Ns photocatalysts. ABSTRACT In this work, we constructed an ultrathin two‐dimensional (2D) In2O3 nanosheet (In2O3‐Ns) structure ...
Yueying Yang +10 more
wiley +1 more source
, 2008 The article offers information on bicarbonate and citrate supplementation. It reveals that bicarbonate and citrate loading increases the extracellular buffering capacity of the muscles and their ability to dispose excess hydrogen ions.
McNaughton, Lars R.; id_orcid +1 more
core +1 more source